SPR imaging biosensor for the quantitation of fibronectin concentration in blood samples

Sankiewicz, Anna; Romanowicz, Lech; Pyc, Marlena; Hermanowicz, Adam; Gorodkiewicz, Ewa

doi:10.1016/j.jpba.2017.11.070

Cited by 39 publications

(32 citation statements)

References 34 publications

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“…SPR sensors have also been used in diverse healthcare biosensing applications, bioimaging paediatric burns [75] as well as in the study of mutations [76] and the effects of radiation exposure [77]. Recent studies have also shown the versatility of such devices in the study of pathogens [78], thermal injuries [79], carcinogens [80] and several clinically vital molecules [81][82][83].…”

Section: Surface Plasmon Resonance Sensors For Biomedical Diagnosticsmentioning

confidence: 99%

Recent Progress in Optical Sensors for Biomedical Diagnostics

Pirzada

Altıntaş

2020

Micromachines

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In recent years, several types of optical sensors have been probed for their aptitude in healthcare biosensing, making their applications in biomedical diagnostics a rapidly evolving subject. Optical sensors show versatility amongst different receptor types and even permit the integration of different detection mechanisms. Such conjugated sensing platforms facilitate the exploitation of their neoteric synergistic characteristics for sensor fabrication. This paper covers nearly 250 research articles since 2016 representing the emerging interest in rapid, reproducible and ultrasensitive assays in clinical analysis. Therefore, we present an elaborate review of biomedical diagnostics with the help of optical sensors working on varied principles such as surface plasmon resonance, localised surface plasmon resonance, evanescent wave fluorescence, bioluminescence and several others. These sensors are capable of investigating toxins, proteins, pathogens, disease biomarkers and whole cells in varied sensing media ranging from water to buffer to more complex environments such as serum, blood or urine. Hence, the recent trends discussed in this review hold enormous potential for the widespread use of optical sensors in early-stage disease prediction and point-of-care testing devices.

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Section: Surface Plasmon Resonance Sensors For Biomedical Diagnosticsmentioning

confidence: 99%

Recent Progress in Optical Sensors for Biomedical Diagnostics

Pirzada

Altıntaş

2020

Micromachines

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“…In addition, the sensitivity is affected by the auto-fluorescence of the analytes and the incubation time of the assay, while the specificity is contaminated by the non-specific interaction between the label. On the contrary, the high sensitivity and specificity with a high percentage of correlations between results obtained in the conventional assay ELISA and the developed SPRi of the label-free SPRi method is supported by an established protocol, and it is therefore the solution for molecular sensing work [126].…”

Section: Biosensing Applicationsmentioning

confidence: 99%

“…In Figure 10, the deposition of fibronectin (FN), a glycoprotein that is an essential component of the extracellular matrix (ECM), is imaged and quantified. FN present in the plasma acts as a potential biomarker indicating cell adhesion, growth, migration, differentiation, wound healing and embryonic development, and the quantification of the fibronectin concentration shows a dynamic response range between 5 and 400 ng/mL, with a detection limit of 1.5 ng/mL that supports a reliable screening of patients (601 ± 72 g/mL) from healthy donors (140 ± 25 g/mL) [126].…”

Section: Biosensing Applicationsmentioning

confidence: 99%

Recent Advances in Surface Plasmon Resonance Imaging Sensors

Wang

Loo

Chen

et al. 2019

Sensors

115

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The surface plasmon resonance (SPR) sensor is an important tool widely used for studying binding kinetics between biomolecular species. The SPR approach offers unique advantages in light of its real-time and label-free sensing capabilities. Until now, nearly all established SPR instrumentation schemes are based on single- or several-channel configurations. With the emergence of drug screening and investigation of biomolecular interactions on a massive scale these days for finding more effective treatments of diseases, there is a growing demand for the development of high-throughput 2-D SPR sensor arrays based on imaging. The so-called SPR imaging (SPRi) approach has been explored intensively in recent years. This review aims to provide an up-to-date and concise summary of recent advances in SPRi. The specific focuses are on practical instrumentation designs and their respective biosensing applications in relation to molecular sensing, healthcare testing, and environmental screening.

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“…The papers pertaining to stages (iii) and (iv) represent complete analytical procedures [14,15,16,17,18,19,20,21,22,23,24,25,26,27]. These biosensors and related analytical procedures are ready to be subjected to clinical investigation for subsequent use in diagnosis.…”

Section: Stages Of Biosensor Developmentmentioning

confidence: 99%

Section: Figurementioning

confidence: 99%

Recent Progress in Surface Plasmon Resonance Biosensors (2016 to Mid-2018)

Gorodkiewicz

Łukaszewski

2018

Biosensors

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More than 50 papers on surface plasmon resonance biosensors, published between 2016 and mid-2018, are reviewed. Papers concerning the determination of large particles such as vesicles, exosomes, cancer cells, living cells, stem cells, and microRNA are excluded, as these are covered by a very recent review. The reviewed papers are categorized into five groups, depending on the degree of maturity of the reported solution; ranging from simple marker detection to clinical application of a previously developed biosensor. Instrumental solutions and details of biosensor construction are analyzed, including the chips, receptors, and linkers used, as well as calibration strategies. Biosensors with a sandwich structure containing different nanoparticles are considered separately, as are SPR (Surface Plasmon Resonance) applications for investigating the interactions of biomolecules. An analysis is also made of the markers determined using the biosensors. In conclusion, there is shown to be a growing number of SPR applications in the solution of real clinical problems.

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SPR imaging biosensor for the quantitation of fibronectin concentration in blood samples

Cited by 39 publications

References 34 publications

Recent Progress in Optical Sensors for Biomedical Diagnostics

Recent Progress in Optical Sensors for Biomedical Diagnostics

Recent Advances in Surface Plasmon Resonance Imaging Sensors

Recent Progress in Surface Plasmon Resonance Biosensors (2016 to Mid-2018)

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