Spray drying of mixed amino acids: The effect of crystallization inhibition and humidity treatment on the particle formation

Carbon nanofiber/taurine-catalyzed synthesis of coumarin and 1,2,4,5-tetra-substituted imidazole derivatives under metal-free conditions

“…After the functionalization of taurine on CNF, the CNF/T nano-catalyst was successfully prepared. The prepared nano-catalyst shows similar diffraction peaks compared to taurine and CNF 40,41 .…”

Protein nanoparticles directed cancer imaging and therapy

“…Spray drying is a liquid atomization technology, an important method for producing a drying powder. It disperses the solution into small droplets through a nozzle, transmits heat and mass using a hot and drying medium, and obtains dry particles through the evaporation of the solvent [103][104][105]. Recently, spray drying has been wellestablished as the preparation strategy for protein nanoparticles [106,107] [99] spray drying method for improving collection efficiency of a typical spray drying method [107].…”

Glycine microparticles loaded with functionalized nanoparticles for pulmonary delivery

“…Several methods such as spray-drying and freeze-drying can be employed (Liu et al, 2005). However, spray drying is a favored method for development of inhalable dry powder (Yang, 2015;Nandiyanto and Okuyama, 2011) due to its scalability, adaptability, cost, encapsulation efficiency (Sou, 2016) as well as generating uniform, monodisperse particles with higher stability and nanoparticle entrapment capability (Lin, 2017;Wu, 2011). Glycine has been used to encapsulate antibiotics for inhalation, however the dryer used (Buchi 290) generates non-uniform, agglomerates of spray-dried powder due to aerosolization of glycine, instead of even microparticle formation, as could be produced with the much more advanced micro-fluidic jet spray dryer which uses a piezoelectric droplet generator (Lin, 2017;Lin, 2015;Liu, 2011).…”

“…However, spray drying is a favored method for development of inhalable dry powder (Yang, 2015;Nandiyanto and Okuyama, 2011) due to its scalability, adaptability, cost, encapsulation efficiency (Sou, 2016) as well as generating uniform, monodisperse particles with higher stability and nanoparticle entrapment capability (Lin, 2017;Wu, 2011). Glycine has been used to encapsulate antibiotics for inhalation, however the dryer used (Buchi 290) generates non-uniform, agglomerates of spray-dried powder due to aerosolization of glycine, instead of even microparticle formation, as could be produced with the much more advanced micro-fluidic jet spray dryer which uses a piezoelectric droplet generator (Lin, 2017;Lin, 2015;Liu, 2011). Using the micro-fluidic jet spray-dryer, we can alter the particles' physicochemical properties including size, distribution, density, shape, morphology without aggregation issues of nanoparticles (Seville et al, 2007), as the nanoparticles are suspended in the bulk excipient (glycine for example).…”