Spray-Drying Performance and Thermal Stability of L-Ascorbic Acid Microencapsulated with Sodium Alginate and Gum Arabic

Abstract

The potential of sodium alginate (ALG) and gum arabic (GA) as wall polymers for Lascorbic acid (AA) encapsulation as a tool for their preservation against the thermooxidative degradation was investigated. The influence of such polymers used as wall material on the AA-content, size, encapsulation efficiency, encapsulation yield and thermo-oxidative stability were evaluated. The AA-microparticles were obtained using the spray-drying technique. An experimental Taguchi design was employed to assess the influence of the variables in the encapsulation process. The microparticles morphology and size distribution were characterized by scanning electron microscopy and laser diffraction. The thermal stability of AA microparticles was studied by differential scanning calorimetry and thermogravimetry analysis. This work points out the viability to encapsulate AA using GA and ALG through a spray-drying process. In general, a product yield ranging from 35.1% to 83.2% and an encapsulation efficiency above 90% was reached. Spherical microparticles with a smooth surface were obtained with a mean diameter around 6 μm and 9 μm for the those prepared with GA and ALG, respectively.The thermo-oxidative analysis showed that both polymers allow maintaining AA stable up to 188 °C, which is higher than the traditional processing temperature used in the fish feed industry.

Chemical characteristics and targeted encapsulated Cordia myxa fruits extracts nanoparticles for antioxidant and cytotoxicity potentials

“…Obtained DSC curves can show endo- and exo -thermic peaks where higher temperature of peaks can be indicating the higher thermal stability of tested materials. As reported for the ascorbic acid thermo-oxidative stability by gum Arabic and sodium alginate polymers up to 188 °C that is higher than the traditional processing temperature used in the fish feed industry ( Barra et al, 2019 ). The nano capsule has improved the rosemary essential oil thermal stability and can also be preserve the antioxidant capacity especially in the industry of thermal treatment various applications ( Dehghan et al, 2020 ).…”

Review Sinergisitas Kombinasi Polimer Alami Serta Pemanfaatan dalam Formulasi Obat

“…Alginat telah banyak digunakan secara luas untuk formulasi (Tabel 2). Kombinasi alginat dengan gum akasia telah banyak digunakan dalam formulasi mengenkapsulasi bahan aktif yang bertujuan untuk mencegah degradasi (50) , meningkatkan stabilas thermal dan kimia (26,(51)(52)(53) , mengurangi toksisitas (54,55) , meningkatkan efektivitas zat aktif (55,56) , meningkatkan efiesiensi enkapsulasi (8,57) , meningkatkan adsorpsi pada mata (58) , serta mengontrol pelepasan zat aktif (25,34,57,59) . Kombinasi alginat dengan pektin telah banyak digunakan dalam industri makanan, farmasi, kosmetik, dan biomedis dikarenakan interaksinya yang sinergi.…”

Characterization of Alginate with Natural Polymers Combination for Drug Encapsulation

“…have been widely used in drug formulation. to encapsulate active ingredients to prevent degradation (1) , improve thermal and chemical stability (2)(3)(4)(5) , reduce toxicity (6,7) , increase the effectiveness of active substances (7,8) , control the release of the active substance (9)(10)(11)(12) , improve mechanical properties of microbeads (13) , and as a carrier for drug targeting (14) .…”