Spray Freeze Drying

Luy, Bernhard; Stamato, Howard

doi:10.1002/9783527802104.ch8

Cited by 11 publications

(4 citation statements)

References 12 publications

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“…Sebaliknya, dalam waktu yang sama sejumlah butir air berubah wujud menjadi es, sehingga jumlah netto butir air dan es selalu tetap. Hubungan antara tekanan dan suhu keseimbangan zat dapat dilukiskan dalam diagram, seperti pada diagram dibawah ini 24,25,26,27 . Gambar 2.…”

Section: Metode Penelitianunclassified

Liofilisasi Hemolisat Packed Red Cell Limbah Darah Palang Merah Indonesia dengan Penambahan Lioprotektan sebagai Alternatif Standar Hemoglobin

Supriyanta,

Rahmawati,

Martsiningsih

et al. 2024

JKT

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Lyophilization of PRC waste added with 20% sucrose as lyoprotectant. This study aimed to create an alternative Hb standard, replacing the manufacturer's Hb standard. This study used an experimental with pre and posttest without control group design. PMI blood waste PRC was processed into hemolysate, added with lyoprotectant, lyophilized, checked Hb levels using the Cyanmethemoglobin method as a grouppre test, stored at 4OC for six months, checked Hb levels with the Cyanmethemoglobin method as a grouppost test. Homogeneity Test and Stability Test were carried out according to ISO 13528:2015. The average Hb level of PRC lyophilisate before storage (Xr)=15.06 g/dl, obtained Ss≤0.3σpt, so that it was declared homogeneous according to the homogeneous acceptability value according to ISO 13528: 2015. After being stored for six months at 4OC, the average level of Hb lyophilisate PRC (Yr) =14,68 g/dl, obtained |Xr-Yr| ≤ 0.3σpt so that it was declared stable according to the stable acceptability value according to ISO 13528: 2015. Hb levels of PRC lyophilisate were stated to be homogeneous and stable for six months. Hb standard from PRC lyophilisate can be used as an alternative to commercial Hb standard.

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Section: Metode Penelitianunclassified

Liofilisasi Hemolisat Packed Red Cell Limbah Darah Palang Merah Indonesia dengan Penambahan Lioprotektan sebagai Alternatif Standar Hemoglobin

Supriyanta,

Rahmawati,

Martsiningsih

et al. 2024

JKT

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“…5 Buserelin is a peptide analog of hypothalamic gonadotropin-releasing hormone (GnRH) used to treat premature puberty, prostate cancer, uterine leiomyoma, endometriosis and ovulation stimulation. 6,7 Comprehensive application of GnRH analogs has been a reason for developing various dosage forms, including injectable solutions, slow-release systems and nasal spray. 8 Due to the invasive nature of injection and the variation in the bioavailability of the drug through the nasal route (2.5 to 6%), it seems to be useful to obtain a dosage form that solves the problems of available buserelin products in the market.…”

Section: Introductionmentioning

confidence: 99%

“…[14][15][16] The general principle of this method is atomization of feed solution into liquid nitrogen and then lyophilization of frozen droplets to allow the solvent to be sublimated at low temperature and vacuum conditions (Figure 1). 7,8 Spraying and rapid freezing of the droplets and sublimation of ice particles in this method create porous spherical particles. As a result, SFD method creates particles with suitable aerodynamic properties, size, density 17 and leading to higher stability in the lungs and nasal mucosa than other conventional drying methods.…”

Section: Introductionmentioning

confidence: 99%

Screening of Cyclodextrins in the Processing of Buserelin Dry Powders for Inhalation Prepared by Spray Freeze-Drying

Rostamnezhad¹,

Mireskandari²,

Rouini³

et al. 2023

Adv Pharm Bull

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In this study, we prepared inhalable buserelin microparticles using the spray freeze-drying (SFD) method for pulmonary drug delivery. Raffinose as a cryoprotectant carrier was combined with two levels of five different cyclodextrins (CDs) and then processed by SFD. Dry powder diameters were evaluated by laser light scattering and morphology was determined by scanning electron microscopy (SEM). Differential scanning calorimetry (DSC) and X-ray diffraction (XRD) analysis were utilized for the determination of crystalline structures. The aerodynamic properties of the spray freeze-dried powders were evaluated by twin stage impinger (TSI) and the stability of prepared samples was assessed under normal and accelerated conditions. The prepared powders were mostly porous spheres and the size of microparticles ranged from 9.08 to 13.53 μm, which are suitable as spray-freeze dried particles. All formulations showed amorphous structure confirmed by DSC and XRD. The aerosolization performance of the formulation containing buserlin, raffinose and 5% beta-cyclodextrin (β-CD), was the highest and its fine particle fraction (FPF) was 69.38%. The more circular and separated structures were observed in higher concentrations of CDs, which were compatible with FPFs. The highest stability was obtained in the formulation containing hydroxypropyl beta-cyclodextrin (HP-β-16. CD) 5%. On the contrary, sulfobutylether beta-cyclodextrin (SBE-β-CD) 5% bearing particles showed the least stability. By adjusting the type and ratio of CDs in the presence of raffinose, the prepared formulations could effectively enhance the aerosolization and stability of buserelin. Therefore, they can be proposed as a suitable career for lung drug delivery.

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“…Spray crystallization is a process in which liquid droplets are sprayed into a cold ambient environment to crystallize into a powder [ 4 ]. It has a direct application in industries such as food products [ 5 , 6 ], ceramics [ 7 ], metallurgy [ 8 ], biology [ 9 ], pharmaceuticals [ 10 , 11 , 12 , 13 , 14 ] and artificial snow production [ 15 ] where spray crystallization has been successfully employed.…”

Section: Introductionmentioning

confidence: 99%

A Three-Stage Solidification Model for Food Particles

Srinivasan

2021

Foods

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A three-stage solidification model for food droplets has been implemented in a computational fluid dynamics code. It comprises of an initial cooling stage that is based on the principles of convective heat transfer. This is followed by the solidification period that is initiated once the droplet cools to a phase change temperature. Finally, when the droplet is completely solidified, the tempering phase begins where the droplet cools to the temperature of the ambient air. The model has been validated with respect to the experimental data for cocoa butter. Additional simulations were made in which the crystallization behavior of the cocoa butter droplets in relation to the droplet size, ambient air temperature and the relative drop-gas velocity was investigated. It was found that the crystallization time is exponentially related to the droplet size. Further, it increased with the ambient temperature, but decreased with the relative drop-gas velocity. Overall, the results suggest operating at the extreme values of the process parameters, requiring high amount of energy, to minimize the crystallization time. It was concluded that there is a need for optimizing the operating conditions of the powder production process to minimize the energy requirement of the system while maintaining a reasonable crystallization time.

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Spray Freeze Drying

Cited by 11 publications

References 12 publications

Liofilisasi Hemolisat Packed Red Cell Limbah Darah Palang Merah Indonesia dengan Penambahan Lioprotektan sebagai Alternatif Standar Hemoglobin

Liofilisasi Hemolisat Packed Red Cell Limbah Darah Palang Merah Indonesia dengan Penambahan Lioprotektan sebagai Alternatif Standar Hemoglobin

Screening of Cyclodextrins in the Processing of Buserelin Dry Powders for Inhalation Prepared by Spray Freeze-Drying

A Three-Stage Solidification Model for Food Particles

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