Spreading Depolarizations Occur in Mild Traumatic Brain Injuries and Are Associated with Postinjury Behavior

Pacheco, Johann M.; Hines-Lanham, Ashlyn; Stratton, Claire; Mehos, Carissa J.; McCurdy, Kathryn E.; Pinkowski, Natalie J.; Zhang, Haikun; Shuttleworth, C. William; Morton, Russell A.

doi:10.1523/eneuro.0070-19.2019

Cited by 26 publications

(16 citation statements)

References 113 publications

(155 reference statements)

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“…The lack of gross motor dysfunction supports that even our RmTBI injury is milder in comparison to other models that typically produce robust motor deficits, as well as gross tissue damage [72][73][74][75] . Our previous study reported no significant motor deficits following a single injury 76 . Even in more mild injuries, motor dysfunction is sometimes detected [77][78][79][80][81][82][83] .…”

Section: Discussionmentioning

confidence: 81%

Repeated mild traumatic brain injuries impair visual discrimination learning in adolescent mice

Pinkowski

Guerin

Zhang

et al. 2020

Neurobiology of Learning and Memory

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Section: Discussionmentioning

confidence: 81%

Repeated mild traumatic brain injuries impair visual discrimination learning in adolescent mice

Pinkowski

Guerin

Zhang

et al. 2020

Neurobiology of Learning and Memory

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“…Two previous studies suggested the occurrence of seizures and SDs in models of mild TBI in mice, based on blood flow measurements [42] and electrophysiological recordings [43]. In the present study, we recorded electrophysiological changes from the cortical surface within seconds following mild and severe TBI in rats.…”

Section: Introductionmentioning

confidence: 70%

“…We first recorded changes in cortical electrocorticography before and immediately after TBI. Following TBI (Figure 1a), the near-direct current recordings showed the characteristic large slow potential change of SD [45], whereas AC recordings showed the rapidly evolving reduction in amplitudes of spontaneous activity that spread along with SD between adjacent recording sites, which is characteristic of spreading depression of activity (Figure 1b-d) [25,34,43,46]. After mild TBI, SDs were observed after 53% of impacts (n = 37 out of 71, Figure 1d), and were recorded within 3 min (124 ± 48 s).…”

Section: Spreading Depolarization Is Common Following Mild and Severe Tbimentioning

confidence: 99%

Brainstem and Cortical Spreading Depolarization in a Closed Head Injury Rat Model

Aboghazleh

Parker

Yang

et al. 2021

IJMS

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Traumatic brain injury (TBI) is the leading cause of death in young individuals, and is a major health concern that often leads to long-lasting complications. However, the electrophysiological events that occur immediately after traumatic brain injury, and may underlie impact outcomes, have not been fully elucidated. To investigate the electrophysiological events that immediately follow traumatic brain injury, a weight-drop model of traumatic brain injury was used in rats pre-implanted with epidural and intracerebral electrodes. Electrophysiological (near-direct current) recordings and simultaneous alternating current recordings of brain activity were started within seconds following impact. Cortical spreading depolarization (SD) and SD-induced spreading depression occurred in approximately 50% of mild and severe impacts. SD was recorded within three minutes after injury in either one or both brain hemispheres. Electrographic seizures were rare. While both TBI- and electrically induced SDs resulted in elevated oxidative stress, TBI-exposed brains showed a reduced antioxidant defense. In severe TBI, brainstem SD could be recorded in addition to cortical SD, but this did not lead to the death of the animals. Severe impact, however, led to immediate death in 24% of animals, and was electrocorticographically characterized by non-spreading depression (NSD) of activity followed by terminal SD in both cortex and brainstem.

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“…CSD was associated with lower prehospital systolic blood pressure and a poor neurologic recovery (odds ratio [OR] 2.29). 22,23 This electrochemical and neurovascular imbalance explains the frequently observed differences in clinical presentation of lesional CSD symptomatology versus the more benign nonlesional CSD, such as that observed in migraine aura. 24 The incidence of CSD has been reported to be as high as 60% in TBI, 80% in SAH, and over 90% in aggressive strokes.…”

Section: Cortical Spreading Depolarizationmentioning

confidence: 99%

Cortical Spreading Depolarization in Chronic Subdural Hematoma: Bridging the Gap

Lévesque

Deacon

Adam

et al. 2020

Can. J. Neurol. Sci.

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Cortical spreading depolarization (CSD) is recognized as a cause of transient neurological symptoms (TNS) in various clinical entities. Although scientific literature has been flourishing in the field of CSD, it remains an underrecognized pathophysiology in clinical practice. The literature evoking CSD in relation to subdural hematoma (SDH) is particularly scarce. Patients with SDH frequently suffer from TNS, most being attributed to seizures despite an atypical semiology, evolution, and therapeutic response. Recent literature has suggested that a significant proportion of those patients’ TNS represent the clinical manifestations of underlying CSD. Recently, the term Non-Epileptical Stereoytpical Intermittent Symptoms (NESIS) has been proposed to describe a subgroup of patients presenting with TNS in the context of SDH. Indirect evidence and recent research suggest that the pathophysiology of NESIS could represent the clinical manifestation of CSD. This review should provide a concise yet thorough review of the current state of literature behind the pathophysiology of CSD with a particular focus on recent research and knowledge regarding the presence of CSD in the context of subdural hematoma. Although many questions remain in the evolution of knowledge in this field would likely have significant diagnostic, therapeutic, and prognostic implications.

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Spreading Depolarizations Occur in Mild Traumatic Brain Injuries and Are Associated with Postinjury Behavior

Cited by 26 publications

References 113 publications

Repeated mild traumatic brain injuries impair visual discrimination learning in adolescent mice

Repeated mild traumatic brain injuries impair visual discrimination learning in adolescent mice

Brainstem and Cortical Spreading Depolarization in a Closed Head Injury Rat Model

Cortical Spreading Depolarization in Chronic Subdural Hematoma: Bridging the Gap

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