SPYROFLEX™: A Tryptosorbent Wound Dressing and Wound Closure

Ives, Christopher L.; Reed, Andrew M.; Szycher, Michael

doi:10.1177/088532829200600405

Cited by 2 publications

(1 citation statement)

References 6 publications

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“…Indications for the use of spyrosorbents are similar to those of hydrocolloids (Table 2). An additional application of spyrosorbents is in wound closure (Ives et al, 1992;Szycher & Lee, 1992), since the dressing possesses enough conformability and elasticity to be used as a wound closure tape. Contraindications for the use of spyrosorbents are also similar to those of hydrocolloids.…”

Section: Athletic Theraw Todavmentioning

confidence: 99%

Use of Occlusive Dressings in Wound Management

Riemann¹

1997

Athletic Therapy Today

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Section: Athletic Theraw Todavmentioning

confidence: 99%

Use of Occlusive Dressings in Wound Management

Riemann¹

1997

Athletic Therapy Today

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Biomedical Applications of Polyurethanes: A Review of Past Promises, Present Realities, and a Vibrant Future

Zdrahala¹,

Zdrahala²

1999

J Biomater Appl

485

288

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Polyurethanes, having extensive structure/property diversity, are one of the most bio- and blood-compatible materials known today. These materials played a major role in the development of many medical devices ranging from catheters to total artificial heart. Properties such as durability, elasticity, elastomer-like character, fatigue resistance, compliance, and acceptance or tolerance in the body during the healing, became often associated with polyurethanes. Furthermore, propensity for bulk and surface modification via hydrophilic/hydrophobic balance or by attachments of biologically active species such as anticoagulants or biorecognizable groups are possible via chemical groups typical for polyurethane structure. These modifications are designed to mediate and enhance the acceptance and healing of the device or implant. Many innovative processing technologies are used to fabricate functional devices, feeling and often behaving like natural tissue. The hydrolytically unstable polyester polyurethanes were replaced by more resistant but oxidation-sensitive polyether polyols based polyurethanes and their clones containing silicone and other modifying polymeric intermediates. Chronic in vivo instability, however, observed on prolonged implantation, became a major roadblock for many applications. Presently, utilization of more oxidation resistant polycarbonate polyols as soft segments, in combination with antioxidants such as Vitamin E, offer materials which can endure in the body for several years. The applications cover cardiovascular devices, artificial organs, tissue replacement and augmentation, performance enhancing coatings and many others. In situ polymerized, cross-linked systems could extend this biodurability even further. The future will expand this field by revisiting chemically-controlled biodegradation, in combination with a mini-version of RIM technology and minimally invasive surgical procedures, to form, in vivo, a scaffold, by delivery of reacting materials to the specific site in the body and polymerizing the mass in situ. This scaffold will provide anchor for tissue regeneration via cell attachment, proliferation, control of inflammation, and healing.

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SPYROFLEX™: A Tryptosorbent Wound Dressing and Wound Closure

Cited by 2 publications

References 6 publications

Use of Occlusive Dressings in Wound Management

Use of Occlusive Dressings in Wound Management

Biomedical Applications of Polyurethanes: A Review of Past Promises, Present Realities, and a Vibrant Future

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