SQAGs: A stepping stone in the biotic world

Anionic glycolipids related to glucuronosyldiacylglycerol inhibit protein kinase Akt

“…4 Differently from GlcADGs, in the last years both natural and synthetic sulfoquinovosylacylglycerols 25 have been tested for their antitumor, antiviral, anti-inflammatory, immunosuppressive and other bioactivities. [9][10][11][12][13] This prompted us to prepare some SQDG analogues (figure 1) based on 2-O-β-Dglucosylglycerol, which were tested as inhibitors of tumorpromoters in cancer prevention studies. 14a,15 These unnatural 30 sulfolipids, similarly to other glucose-based compounds, 16 display a structure which can be related to that of 3-phosphorylated phosphatidylinositol (PI3P, figure 1), one of the natural phospholipids involved in the regulation of specific lipid-binding domains (e.g.…”

“…4 In contrast to GlcADGs, in the last few years both natural and synthetic sulfoquinovosylacylglycerols have been tested for their antitumor, antiviral, anti-inflammatory, immunosuppressive and other bioactivities. [9][10][11][12][13] This prompted us to prepare some SQDG analogues (Fig. 1) based on 2-O-β-D-glucosylglycerol, which were tested as inhibitors of tumor-promoters in cancer prevention studies.…”

Total Synthesis and Structure-Activity Relationship of Glycoglycerolipids from Marine Organisms

“…Recently, naturally occurring sulfoquinovosylglycerolipids have come to be considered promising compounds for cancer therapy and prevention due to their good bioactivities [ 34 ]. For example, SQDGs isolated from a marine red algae ( Gigartina tenella ) [ 35 , 36 ], higher plants of pteridophyte ( Athqrium niprmicum ) [ 37 ], and spinach [ 23 , 38 ], were proved to have inhibition on replicative DNA polymerase and antiproliferative activity toward human cancer cells.…”

Phyto‐Pharmacological Review onMurraya koenigii(L.) Spreng: As an Indigenous Plant of India with High Medicinal Potential

“…Traditionally, the plant has been used in many ailments, including skin eruptions, dysentery, diarrhea, diabetes, kidney and stomach pain. [1][2][3][4] This review on M. koenigii (L.) Spreng provides the latest information in all relevant aspects, including phytoconstituents, ethnobotanical applications, and pharmacological, with some available evidence on the molecular mechanism of phytoconstituents and even published patents.…”