Squamoid eccrine ductal carcinoma

Abstract

Squamoid eccrine ductal carcinoma is an eccrine carcinoma subtype, and only twelve cases have been reported until now. It is a rare tumor and its histopathological diagnosis is difficult. Almost half of patients are misdiagnosed as squamous cell carcinoma by the incisional biopsy. We report the thirteenth case of squamoid eccrine ductal carcinoma. Female patient, 72 years old, in the last 6 months presenting erythematous, keratotic and ulcerated papules on the nose. The incisional biopsy diagnosed squamoid eccrine ductal carcinoma. After excision, histopathology revealed positive margins. A wideningmargins surgery and grafting were performed, which again resulted in positive margins. The patient was then referred for radiotherapy. After 25 sessions, the injury reappeared. After another surgery, although the intraoperative biopsy showed free surgical margins, the product of resection revealed persistent lesion. Distinction between squamoid eccrine ductal carcinoma and squamous cell carcinoma is important because of the more aggressive nature of the first, which requires wider margins surgery to avoid recurrence.

Current Diagnosis and Treatment Options for Cutaneous Adnexal Neoplasms with Apocrine and Eccrine Differentiation

“…White individuals have a higher risk than black. The most significant analysis is 30 patients subsumed into a publication [ 160 ].…”

“…In the macroscopic and microscopic evaluation, the cytologic atypia was moderate to severe, ulceration (47%), necrosis (23%), and perineural and lymphovascular infiltration (27% and 6%, respectively). Distant metastasis is relatively rare [ 160 ].…”

“…The local recurrence rate is 25%, not related to completeness of resection after median 29-month follow-up. In a recent case series, the metastatic spread was observed in 13% of cases, and one patient died of metastatic disease [ 160 ]. Saraiva et al reported the patient who underwent adjuvant radiotherapy (in linear accelerator with an energy beam of 6 mV at a dose of 66 Gy in two cycles) because of double incomplete excision.…”

Squamoid Eccrine Ductal Carcinoma of the Eyelid: Clinicopathologic Correlation of a Case

“…8 Over the course of almost 20 years, less than a dozen subsequent cases of this entity were reported, many in the form of case reports or small case series. 9,10 In 2016, a clinicopathologic study of 30 cases was published and showed that SEDC typically manifests as ulcerated nodules and plaques in sun-exposed areas, primarily the face, in the seventh and eighth decades of life. Histologically, these tumors demonstrate a biphasic appearance.…”

Dermoscopy of squamoid eccrine ductal carcinoma: an aid for early diagnosis

“…This clinical non-specificity often leads to incomplete biopsies (shavings), diagnostic delay, and negative impact on prognosis. 2 , 3 …”