Squamous carcinoma arising in dermoid cysts and associated with hypercalcemia: A clinicopathologic study of six cases

Ribeiro, G; Hughesdon, P. E.; Wiltshaw, E.

doi:10.1016/0090-8258(88)90216-8

Cited by 43 publications

(42 citation statements)

References 15 publications

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“…Hypercalcemia may occur as with other squamous carcinomas. 12 Mori et al combined age and SCC antigen in a predictive model and found that, using SCC antigen of less than 2.5 ng/mL and age of less than 40 years as the cutoff, the sensitivity for detecting malignant transformation was 77% and the specificity was 96%. 13 Raised preoperative levels of CA125 and SCC antigen are also associated with poorer survival.…”

Section: Diagnosismentioning

confidence: 99%

Gynecologic Cancer InterGroup (GCIG) Consensus Review for Squamous Cell Carcinoma of the Ovary

Glasspool

González-Martín

Millan

et al. 2014

Int J Gynecol Cancer

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Squamous cell carcinoma of the ovary is a rare complication of mature cystic teratoma. The epidemiology, pathology, diagnosis, and management of this rare tumor are reviewed. Clinical characteristics, preoperative imaging, and tumor markers may help to predict malignancy preoperatively. Complete cytoreduction should be the aim of surgery. The prognosis for stage 1A disease is good, but for women with advanced or recurrent disease, it is very poor and has not improved in recent years. At present, there are insufficient data to provide clear guidance on the optimal management strategy for advanced disease, and there is a need to gain an understanding of the biology and to develop novel effective therapies. This will require coordinated international collaboration.

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Section: Diagnosismentioning

confidence: 99%

Gynecologic Cancer InterGroup (GCIG) Consensus Review for Squamous Cell Carcinoma of the Ovary

Glasspool

González-Martín

Millan

et al. 2014

Int J Gynecol Cancer

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“…These tumors occur bilaterally 10% to 17% of the time in women of childbearing age. 4,5 Most patients with MCTs are asymptomatic but can develop pain and abdominal distension because of the mass compression effect. 6 More than 80% of malignant transformations (MTs) of teratomas are squamous cell carcinomas (SCCs) arising from the ectoderm; the rest are carcinoid tumors or adenocarcinomas.…”

mentioning

confidence: 99%

Squamous Cell Carcinoma Arising From Mature Cystic Teratoma of the Ovary

Chiang

La²,

Peng³

et al. 2011

Int J Gynecol Cancer

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: With our review as basis, we recommend being cautious of the following risk factors: patient age, tumor size, ultrasound characteristics, sonar tumor vessel wave form, computed tomography, and levels of SCC and CA125 tumor markers. We suggest that patients have regular ovarian ultrasound examination. Based on our literature review, stage IA patients who undergo standardized operational procedures do well without adjuvant treatment, but such patients must be confirmed accurately with complete surgical staging to be in stage IA before undergoing conservative management. The optimal approach to the management of patients with advanced stage and recurrent disease is unclear. Surgical cytoreduction with proper staging, adjuvant therapy with platinum-based or paclitaxel-based chemotherapy, and concurrent whole pelvic radiation have been recommended as possible methods of treatment.

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“…Environ 1 à 2 % des TKM présentent un contingent malin [1,2]. Le type carcinome épidermoïde est retrouvé dans 80 % des cas environ [1,3,4], surtout chez les femmes ménopausées. De ce fait, il n'existe actuellement aucun dépistage efficace d'un tel événement http pathologique.…”

Section: Introductionunclassified

Dégénérescence des kystes dermoïdes. À propos d'un cas de transformation maligne

Argoitia

Duga

et al. 2007

Gynécologie Obstétrique & Fertilité

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Squamous carcinoma arising in dermoid cysts and associated with hypercalcemia: A clinicopathologic study of six cases

Cited by 43 publications

References 15 publications

Gynecologic Cancer InterGroup (GCIG) Consensus Review for Squamous Cell Carcinoma of the Ovary

Gynecologic Cancer InterGroup (GCIG) Consensus Review for Squamous Cell Carcinoma of the Ovary

Squamous Cell Carcinoma Arising From Mature Cystic Teratoma of the Ovary

Dégénérescence des kystes dermoïdes. À propos d'un cas de transformation maligne

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