Squamous Cell Carcinoma and Malignant Lymphoma as Synchronous Malignant Tumours in the Oral Cavity

Morita, Yoshihiro; Kimoto, Natsuko; Ogawa, Hisashi; Omata, Tetsuji; Morita, Nobuo

doi:10.1016/s0915-6992(09)80025-3

Cited by 3 publications

(2 citation statements)

References 8 publications

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“…Although there are published case reports of synchronous SCC of the aerodigestive tract and NHL [22][23][24][37][38][39][40][41][42][43][44][45][46][47][48], this is the first to report a dramatic response of SCC to R-CHOP.This case highlights the exquisite sensitivity of HPV-related HNSCC, which should be taken into consideration in treatment prioritization in the setting of a concurrent diagnosis of a second cancer. The exact agent(s) responsible for the observed response is unclear but the immunomodulatory effect of rituximab and/or the cytotoxic effect of cyclophosphamide, doxorubicin and vincristine could each have played a role.…”

Section: Discussionmentioning

confidence: 77%

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Response to R-CHOP in HPV-related squamous cell carcinoma of base of tongue: a case report

et al. 2018

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Background: Synchronous squamous cell carcinoma of the head and neck (HNSCC) and non-Hodgkin's lymphoma is a rare clinical scenario. It is unknown whether the R-CHOP chemotherapy for lymphoma would also be active against HNSCC. Herein, we present such a case and a review of the literature. Case presentation: A 64 year-old female presented with painless jaundice. CT demonstrated a retroperitoneal mass and pathology showed follicular lymphoma. A base-of-tongue HPV + squamous cell carcinoma was found incidentally on staging CT. R-CHOP chemotherapy was initiated. After 3 cycles of R-CHOP the lymphoma had a complete metabolic response and, unexpectedly, the HNSCC also demonstrated excellent response. The patient received another 3 cycles followed by radiation to the HNSCC and to date is in remission for both cancers. Conclusions: This case highlights the exquisite sensitivity of HPV-related HNSCC, which should be taken into consideration in treatment prioritization of a concurrent diagnosis of a second cancer.

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Section: Discussionmentioning

confidence: 77%

“…A literature search (Table 1). Lymphoma achieved complete response in 2 cases [22,23] and partial response in the other [24]. In contrast, SCC achieved partial response in 1 case [22] and stability/progression in 2 cases [23,24].…”

Section: Discussionmentioning

confidence: 97%

Response to R-CHOP in HPV-related squamous cell carcinoma of base of tongue: a case report

et al. 2018

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Synchronous Head and Neck Squamous Cell Carcinoma and Hematologic Malignancies

Huang,

Lien,

Lin

et al. 2024

Journal of Craniofacial Surgery

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Synchronous occurrence of solid tumors and hematological malignancy is a rare condition. There is no standard management or therapy for this complicated situation. The authors systematically reviewed articles searched using online databases. The patients are predominantly male, and the average age is similar to each malignancy. According to these studies, most patients are treated in order of aggressiveness. However, when a patient has multiple primary malignancies, all of which are aggressive, the treatment decision is challenging. Due to the limited number of cases, it is hard to have a firm conclusion about an optimal treatment policy. It appears that poor outcomes are mostly related to less adequate therapy. Because the condition is complicated in such cases and there is no standardized treatment, patients should be treated on an individual basis with treatments customized to a given patient’s particular circumstances. In addition, multidisciplinary communication and cooperation are crucial in the management of these patients. More in-depth research is still needed to reach a more conclusive treatment strategy and predictable outcomes.

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A case of multidisciplinary treatment for a synchronous double cancer of squamous cell carcinoma of the tongue and malignant lymphoma

Kanemoto

Obata

Ryumon

et al. 2023

Jpn. J. Oral. Maxillofac. Surg.

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Squamous Cell Carcinoma and Malignant Lymphoma as Synchronous Malignant Tumours in the Oral Cavity

Cited by 3 publications

References 8 publications

Response to R-CHOP in HPV-related squamous cell carcinoma of base of tongue: a case report

Response to R-CHOP in HPV-related squamous cell carcinoma of base of tongue: a case report

Synchronous Head and Neck Squamous Cell Carcinoma and Hematologic Malignancies

A case of multidisciplinary treatment for a synchronous double cancer of squamous cell carcinoma of the tongue and malignant lymphoma

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