Squamous cell carcinoma arising from a lesion of disseminated superficial actinic porokeratosis

Abstract

We report a 69-year-old man with disseminated superficial actinic porokeratosis (DSAP) who developed a hyperkeratotic lesion on the distal third of the right forearm with the characteristic histopathological findings of squamous cell carcinoma and DSAP. A review of the literature revealed only four similar cases.

Squamous Cell Carcinoma Developing within Lesions of Disseminated Superficial Actinic Porokeratosis

“…The distribution of typical lesions is symmetric and usually affects sun-exposed areas. The lesions generally spare the face, palms, soles, and mucosal surfaces1,7. DSAP can affect people of all ages, but manifests during the 3rd or 4th decade of life.…”

“…Malignancies have been reported for porokeratosis of Mibelli, linear porokeratosis, porokeratosis palmaris et plantaris and DSAP3-7,10,11. Associated malignancies are squamous cell carcinoma, Bowen's disease and basal cell carcinoma.…”

“…Associated malignancies are squamous cell carcinoma, Bowen's disease and basal cell carcinoma. Squamous cell carcinoma arising in the classic type of porokeratosis of Mibelli is well-documented, but there are only a few reports of squamous cell carcinoma in DSAP3-7. All of the reported squamous cell carcinoma cases arising from DSAP lesions have originated in the distal extremities.…”

“…Development of squamous cell carcinoma within the classic type of porokeratosis of Mibelli is well-documented, but there are only a few reports of squamous cell carcinoma in DSAP3-7. We describe a case of squamous cell carcinoma developing within lesions of DSAP.…”

Fine mapping and identification of a candidate geneSSH1 in disseminated superficial actinic porokeratosis

“…An autosomal dominant mode of inheritance with partial penetrance at young ages has been reported (Anderson and Chernosky, 1969). Although rare, the development of a squamous cell carcinoma may occur (Leache et al, 1991); this development underscores the fact that the coronoid lamella represents an abnormal clone with abnormal DNA ploidy and mutation (Otsuka et al, 1989). Two loci for DSAP were mapped to a 9.6-cM interval on chromosome 12q23.2-24.1 (Xia et al, 2000), and a 6.4-cM region on chromosome 15q25.1-26.1 respectively in two Chinese families (Xia et al, 2002).…”