Squamous cell carcinoma arising in unilateral Warthin′s tumor of parotid gland

Sharma, Monika; Chintamani,; Saxena, Sunita; Agrawal, Usha

doi:10.4103/0973-029x.44585

J Oral Maxillofac Pathol

2008

DOI: 10.4103/0973-029x.44585

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Squamous cell carcinoma arising in unilateral Warthin′s tumor of parotid gland

Monika Sharma

Chintamani Chintamani

Sunita Saxena

et al.

Abstract: Warthin's tumor is a well-defi ned benign salivary gland neoplasm consisting of both epithelial and lymphoid components. Malignant transformation is extremely rare and the differential diagnosis of metastasis of an epidermoid carcinoma to Warthin's tumor is important. We present a case with squamous cell carcinoma arising in unilateral Warthin's tumor of parotid gland in a 16-year-old female patient.

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Cited by 7 publications

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Incidence of Non-Salivary Gland Neoplasms in Patients with Warthin Tumor: A Study of 73 Cases

Zaccarini

Khurana

2019

Head and Neck Pathol

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Warthin tumor is the second most common benign parotid neoplasm. Its association with non-salivary gland neoplasms has been sporadically reported. We reviewed clinical records of Warthin tumor diagnosed on aspiration cytology and surgical pathology to determine if there is any association with other extra-salivary gland malignant neoplasms. Computer search was made for all cases of Warthin tumor diagnosed in the parotid gland by aspiration cytology and surgical pathology at our institution between January 2007 and August 2016. Clinical records of all cases were reviewed for any associated malignant neoplasms and any surgical follow up. All available cytology and histologic material was reviewed. Seventy-three patients (mean 66.9, M:F 1.1:1, age range 43 to 87 years) with Warthin tumor were identified. 45 (62%) were diagnosed on aspiration cytology only, 19 (26%) had cytologic diagnosis as well as concordant surgical follow up, and 9 (12%) were diagnosed based on surgical pathology only. Average age for patients with and without secondary malignancy was 70.5-years, and 63.4-years, respectively (p < 0.05). Average pack years for patients with and without secondary malignancy was 45.4, and 39.8, respectively (p > 0.05). Twenty-seven (37.0%) patients harbored a malignant neoplasm. Association of extra salivary gland malignant neoplasms in 37.0% of our cases suggest that the prevalence of secondary non-salivary neoplasms in patients harboring Warthin tumor might have been underestimated. Squamous cell carcinoma was the most commonly associated non-salivary malignant neoplasm. The association of Warthin tumor with smoking plays an important role in this increased rate of malignancy, and this is supported by the fact that smoking is highly associated with head and neck and lung cancers.

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Incidence of Non-Salivary Gland Neoplasms in Patients with Warthin Tumor: A Study of 73 Cases

Zaccarini

Khurana

2019

Head and Neck Pathol

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Salivary Duct Carcinoma Arising in a Warthin Tumor of the Parotid Gland: A Rare Case Report with Review of Literature and PD-L1 Expression

Nielson,

Lorenzo,

Agarwal

2023

Head and Neck Pathol

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Squamous Cell Carcinoma Arising in a Parotid Warthin's Tumor: A Case Report and Literature Review

2022

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Warthin's tumor is the second most common benign neoplasm of the parotid gland. Epithelial malignant transformation of Warthin's tumor, especially to squamous cell carcinoma, is a rare event. The authors present a case report of a 57-year-old male patient with a mass in the left parotid gland. This paper documents the appearance of squamous cell carcinoma within Warthin's tumor of the left parotid gland and reviews the other similar features of 12 cases.

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Squamous cell carcinoma arising in unilateral Warthin′s tumor of parotid gland

Cited by 7 publications

References 7 publications

Incidence of Non-Salivary Gland Neoplasms in Patients with Warthin Tumor: A Study of 73 Cases

Incidence of Non-Salivary Gland Neoplasms in Patients with Warthin Tumor: A Study of 73 Cases

Salivary Duct Carcinoma Arising in a Warthin Tumor of the Parotid Gland: A Rare Case Report with Review of Literature and PD-L1 Expression

Squamous Cell Carcinoma Arising in a Parotid Warthin's Tumor: A Case Report and Literature Review

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