Squamous cell carcinoma arising in Hailey-Hailey disease

Holst, Valerie A.; Fair, Kevaghn P.; Wilson, Barbara B.; Patterson, James W.

doi:10.1067/mjd.2000.100542

Cited by 53 publications

(23 citation statements)

References 31 publications

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“…There are 4 reports of squamous cell carcinoma and 2 reports of basal cell carcinoma arising in lesions of HHD. 3, 9-15 Presumably, the impaired epidermal barrier may allow for infection with oncogenic strains of human papilloma virus (HPV), thus promoting the development of squamous cell carcinoma. HPV was detected in 1 case of HHD-associated squamous cell carcinoma.…”

Section: Discussionmentioning

confidence: 99%

“…2 Family history is often of help in diagnosis; however, up to one third of cases represent sporadic mutations with no family history. 3 Histologically, HHD is characterized by extensive epidermal suprabasilar acantholysis, which may have the appearance of a “dilapidated brick wall”. In 2000, Hu and Sudbrak identified the ATP2C1 gene located on chromosome 3q21-q24.…”

Section: Introductionmentioning

confidence: 99%

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Two Patients With Hailey-Hailey Disease, Multiple Primary Melanomas, and Other Cancers

Mohr

Erdag²,

Shada

et al. 2011

Arch Dermatol

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Two Patients With Hailey-Hailey Disease, Multiple Primary Melanomas, and Other Cancers

Mohr

Erdag²,

Shada

et al. 2011

Arch Dermatol

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“…2,[8][9][10][11][12] whereas a few reports have described OSCC arising in acantholytic bullous disease. [15][16][17] PV is histologically characterized by rounded acantholytic cells with intensely eosinophilic cytoplasm, pyknotic nuclei, and perinuclear halos. 1,3 A remarkable histological feature in the present case was the small neoproliferative area located near to the blistering disease.…”

Section: Discussionmentioning

confidence: 99%

Unusual Histological Evidence of Dysplasia in a Case of Oral Pemphigus Vulgaris

et al. 2016

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This report describes the management of an unusual case of oral pemphigus vulgaris (PV). The patient was referred for a painful single bullous lesion together with a small proliferative area localized in the soft palate. Histology and direct immunofluorescence data were consistent for PV but disclosed unusual signs of high-grade dysplasia in the proliferative area. At surgical removal of the dysplastic area 1 week after the start of cortisone therapy there was no evidence of dysplasia. Histological signs of high-grade dysplasia in oral mucosa are often associated with concurrent or subsequent carcinoma. However, severe inflammation may induce reactive epithelial cell changes and hence mimic histologic dysplasia. Pathologic evaluation of dysplasia in an inflammatory disease like PV may be a diagnostic challenge and a careful pathological evaluation is advisable before choosing between surgical and medical approach.

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“…signaling [156,183,184]. In some cases, Hailey-Hailey skin lesions eventually evolve into squamous carcinomas [185]. Of interest, recently an association between cancer and SPCA1 has been reported, although of opposite nature: significantly elevated SPCA1 levels have been described in basal-like breast cancers, while the inhibition of SPCA1 in a breast cancer cell line led to a pronounced alteration in cell growth, morphology and in the processing of insulin-like growth factor receptors, with their functional levels significantly reduced [186].…”

Section: The Golgi Apparatusmentioning

confidence: 99%

Intracellular organelles in the saga of Ca2+ homeostasis: different molecules for different purposes?

Zampese

Pizzo

2011

Cell. Mol. Life Sci.

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An increase in the concentration of cytosolic free Ca(2+) is a key component regulating different cellular processes ranging from egg fertilization, active secretion and movement, to cell differentiation and death. The multitude of phenomena modulated by Ca(2+), however, do not simply rely on increases/decreases in its concentration, but also on specific timing, shape and sub-cellular localization of its signals that, combined together, provide a huge versatility in Ca(2+) signaling. Intracellular organelles and their Ca(2+) handling machineries exert key roles in this complex and precise mechanism, and this review will try to depict a map of Ca(2+) routes inside cells, highlighting the uniqueness of the different Ca(2+) toolkit components and the complexity of the interactions between them.

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Squamous cell carcinoma arising in Hailey-Hailey disease

Cited by 53 publications

References 31 publications

Two Patients With Hailey-Hailey Disease, Multiple Primary Melanomas, and Other Cancers

Two Patients With Hailey-Hailey Disease, Multiple Primary Melanomas, and Other Cancers

Unusual Histological Evidence of Dysplasia in a Case of Oral Pemphigus Vulgaris

Intracellular organelles in the saga of Ca2+ homeostasis: different molecules for different purposes?

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