Squamous Cell Carcinoma Arising in Warthin’s Tumour: A Case Report

Yaranal, PJ

doi:10.7860/jcdr/2012/4683.2697

Cited by 20 publications

(21 citation statements)

References 7 publications

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“…The histopathology of Warthin's tumour is highly distinctive and FNAC fails to detect the lesion in up to 20% of cases 5. On the other hand, FNAB has good overall accuracy for diagnosing salivary gland neoplasm (87–97%) 7…”

Section: Discussionmentioning

confidence: 99%

“…This kind of neoplasia was first described by Warthin in 1929 4. It is more common in men and at an average age of 55 years 1 5…”

Section: Introductionmentioning

confidence: 95%

“…The first case of carcinoma arising from Warthin's tumour was described by Ruebner and Bramhall in 1960 7. In the literature, there are only two reports of Warthin's tumour transformation into poorly differentiated carcinoma9; 32 cases of epidermoid carcinoma arising in Warthin's tumours are described5 and 4 cases of squamous cell carcinoma as a malignant component have been listed by Therkildsen et al 10. In this paper, the authors will present a case of squamous cell carcinoma arising in Warthin's tumour.…”

Section: Introductionmentioning

confidence: 99%

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Squamous carcinoma arising in a parotid Warthin's tumour

Allevi

Biglioli

2014

BMJ Case Reports

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Warthin's tumour is the second most common benign neoplasm to affect the salivary glands. It virtually affects the sole parotid gland. A sudden increase in a tumour's size is usually due to a malignant transformation of the tumour. The transformation of the lymphoid stroma into malignant lymphoma is relatively common, while an epithelial malignancy is extremely rare. In this paper, the authors present a case of squamous cell carcinoma arising in Warthin's tumour. The patient underwent enucleoresection of the tumour. Intraoperative frozen section revealed the presence of a cystic component associated with the squamous cell carcinoma areas. In consideration of the result of the intraoperative consultation, the surgeons decided to enlarge the previous resection by removal of a 30×25 mm cuff from the surrounding parotid tissue. Close follow-up was carried out and 12 months after surgery there was no evidence of recurrence or metastatic neoplasm.

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Section: Discussionmentioning

confidence: 99%

“…This kind of neoplasia was first described by Warthin in 1929 4. It is more common in men and at an average age of 55 years 1 5…”

Section: Introductionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

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Squamous carcinoma arising in a parotid Warthin's tumour

Allevi

Biglioli

2014

BMJ Case Reports

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“…In cases of WT with predominance of the lymphoid component, squamous cells and necrotic/mucoid debris, there can be a significant diagnostic challenge because the squamous element, in particular, is common to squamous cell carcinomas and mucoepidermoid carcinomas [7]. Aspirates dominated by lymphoid components can be indistinguishable from a reactive lymph node or sialadenitis.…”

Section: Introductionmentioning

confidence: 99%

New Insight into Benign Tumours of Major Salivary Glands by Proteomic Approach

et al. 2013

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Major salivary gland tumours are uncommon neoplasms of the head and neck. The increase of precise pre-operative diagnosis is crucial for their correct management and the identification of molecular markers would surely improve the required accuracy. In this study we performed a comparative proteomic analysis of fine needle aspiration fluids of the most frequent benign neoplasms of major salivary glands, namely pleomorphic adenoma and Warthin's tumour, in order to draw their proteomic profiles and to point out their significant features. Thirty-five patients submitted to parotidectomy were included in the study, 22 were identified to have pleomorphic adenoma and 14 Warthin's tumour. Fine needle aspiration samples were processed using a two-dimensional electrophoresis/mass spectrometry-based approach. A total of 26 differentially expressed proteins were identified. Ingenuity software was used to search the biological processes to which these proteins belong and to construct potential networks. Intriguingly, all Warthin's tumour up-regulated proteins such as Ig gamma-1 chain C region, Ig kappa chain C region and Ig alpha-1 chain C region and S100A9 were correlated to immunological and inflammatory diseases, while pleomorphic adenomas such as annexin A1, annexin A4, macrophage-capping protein, apolipoprotein E and alpha crystalline B chain were associated with cell death, apoptosis and tumorigenesis, showing different features of two benign tumours. Overall, our results shed new light on the potential usefulness of a proteomic approach to study parotid tumours and in particular up regulated proteins are able to discriminate two types of benign parotid lesions.

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“…Malignant transformation of Warthin’s tumor is more common in the lymphoid component than the epithelial component, although malignant carcinoma is very rare (0.3%) 8 . Carcinomatous components have been reported as mucoepidermoid carcinoma (MEC) 9 10 11 12 13 , squamous cell carcinoma (the most common) 8 14 , oncocytic carcinoma, adenocarcinoma 15 16 17 18 and undifferentiated carcinoma 19 20 .…”

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confidence: 99%

Mucoepidermoid carcinoma arising in Warthin’s tumor of the parotid gland: Clinicopathological characteristics and immunophenotypes

Song

Xiao

et al. 2016

Sci Rep

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Mucoepidermoid carcinoma (MEC), an extremely rare tumor, arises from the epithelial component of preexisting parotid Warthin tumors (WT). Among the 309 cases of surgically resected WTs in Chinese PLA General Hospital and Beijing Shijitan Hospital of Capital Medical University, 5 cases (1.6%) fulfilled the criteria for MECs transformed from WTs. Clinicopathological characteristics of MECs was demonstrated in order to avoid misdiagnosis of this rare type of tumor. All the 5 patients, 3 males and 2 females, presented painless masses in the parotid gland. MECs were located inside or at the edge of WTs, with an obvious transitional zone between WT and MEC. Basal cells of WTs and epidermoid cells of MECs were strongly positive for cytokeratin CK5/6, CK34βE12, and P63; whereas negative for CK7, CK20, and CEA. Mucous cells of MECs were positive for CK7, CEA, as well as periodic acid-Schiff (PAS), whereas negative for CK5/6, CK34βE12, CK20, and P63. MECs patients were followed up for 25–69 months after surgery, presenting no evidence of recurrence or metastasis. Collectively, MECs arising from WT is very rare. The pathological diagnosis was based on histological morphology, especially the transitional zone between WT and MEC.

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Squamous Cell Carcinoma Arising in Warthin’s Tumour: A Case Report

Cited by 20 publications

References 7 publications

Squamous carcinoma arising in a parotid Warthin's tumour

Squamous carcinoma arising in a parotid Warthin's tumour

New Insight into Benign Tumours of Major Salivary Glands by Proteomic Approach

Mucoepidermoid carcinoma arising in Warthin’s tumor of the parotid gland: Clinicopathological characteristics and immunophenotypes

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