Squamous cell carcinoma associated with inverted papilloma: Recurrence and prognostic factors

Abstract

The purpose of the present study was to review the recurrence and prognostic factors of squamous cell carcinoma (SCC) associated with inverted papilloma (IP). A retrospective chart review was conducted on 21 patients with SCC associated with IP, in the nasal cavity and paranasal sinuses, between March 2007 to March 2017. All patients underwent surgical treatment: Surgery prior to or following adjuvant therapy was performed in 17 patients (81.0%). During a mean follow-up time of 47.4 months (range, 3-123 months), 9 patients (42.9%) experienced local recurrence, and the risk factors of T4 stage and invasive orbital cavity had a significant influence on recurrence. The 1-, 3-, and 5-year overall survival rates were 90.5, 75.4 and 68.5%, and the 1-, 3-, and 5-year disease-specific survival (DSS) rates were 90.5, 80.4 and 80.4%, respectively. The prognosis of patients with stage T4 was not satisfactory compared with those with stage T3 or less, and a positive surgical margin was also significantly associated with poor survival. Overall, SCC associated with IP has a favorable DSS, early diagnosis and complete resection of lesions is required for a good prognosis. Furthermore, aggressive surgical approaches combined with postoperative adjuvant therapy seem to be effective in tumors at stage T4.

Prevalence and association of Epstein-Barr virus infection with sinonasal inverted papilloma and sinonasal squamous cell carcinoma in the northeastern Thai population

“…There was no statistically significant correlation between EBV infection and disease recurrence. Among reported risk factors for recurrence of SNSCC and SIP are patient behavior, [38][39][40]. Among these, the most important factors seem to be staging, incomplete removal, malignancy, and surgical technique [38,39,41,42].…”

Need for long‐term follow‐up in sinonasal inverted papilloma: A Single‐institution experience

“…[18][19][20] Besides the risk of recurrence, there is also the risk of malignant transformation, which is seen in 5% to 11% of all specimens. 14,[21][22][23][24][25][26] Previous series reported a rate of approximately 2:1 of synchronous to metachronous transformation. 22 Treatment of SNIPs primarily consists of David Holzmann and Christian M. Meerwein contributed equally to this study and worked as joint last authors.…”

“…Besides the risk of recurrence, there is also the risk of malignant transformation, which is seen in 5% to 11% of all specimens 14,21‐26 . Previous series reported a rate of approximately 2:1 of synchronous to metachronous transformation 22 .…”

Immunohistochemical Expression of EGFR, NF-kB and Cyclin D1 in Sinonasal Inverted Papilloma and Squamous Cell Carcinoma

“…SSCC occurs from SIP in 2-27% cases. (4) The sinonasal cavity covered with respiratory epithelium suffers squamous metaplasia that continuous to form squamous intraepithelial neoplasia to SSCC. (5) Epidermal growth factor receptor (EGFR) is a 170 kDa protein and a member of the ErbB family from receptor tyrosine kinase (RTK) which promotes cell survival, proliferation, invasiveness.…”