Squamous cell carcinoma in chronic ulcers in leprosy: a review of 38 consecutive cases

Richardus, J. H.; Smith, T C

doi:10.5935/0305-7518.19910044

Cited by 20 publications

(31 citation statements)

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“…In small series and reviews of case reports, Marjolin’s ulcers, carcinomas that arise in sites of chronic wounds are more aggressive with rates of metastasis over 20% 206 . This is true in series describing carcinomas in leg ulcers 207–209 , ulcerated leprosy lesions 210 , scar carcinomas 211,212 , and burns (the most common presentation of Marjolin’s ulcers) 206 , though rates of SCC in burn sites are not significantly increased 213,214 . These associations could result from increased mutagenesis, facilitated by elevated free radicals and continuous cell proliferation in the setting of chronic inflammatory stress 215 .…”

Section: Wound Healing and Chronic Inflammationmentioning

confidence: 97%

Roles of the immune system in skin cancer

Rangwala

Tsai

2011

British Journal of Dermatology

167

147

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Over the past several decades, there has been increasing interest in understanding the roles of the immune system in the development and progression of cancer. The importance of the immune system in human skin cancer has been long recognised based primarily upon the increased incidence of skin cancers in organ transplant recipients and mechanisms of ultraviolet light-mediated immunomodulation. In this review, we integrate multiple lines of evidence highlighting the roles of the immune system in skin cancer. First, we discuss the concepts of cancer immunosurveillance and immunoediting as they might relate to human skin cancers. We then describe the clinical and molecular mechanisms of skin cancer development and progression in the contexts of therapeutic immunosuppression in organ transplant recipients, viral oncogenesis, and ultraviolet light-induced immunomodulation with a primary focus on basal cell carcinoma and squamous cell carcinoma. The clinical evidence supporting expanding roles for immunotherapy is also described. Finally, we discuss recent research examining the functions of particular immune cell subsets in skin cancer and how they might contribute to both anti-tumour and pro-tumour effects. A better understanding of the biological mechanisms of cancer immunosurveillance holds the promise of enabling better therapies.

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Section: Wound Healing and Chronic Inflammationmentioning

confidence: 97%

Roles of the immune system in skin cancer

Rangwala

Tsai

2011

British Journal of Dermatology

167

147

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“…Recent epidemiological studies proved this complication was not as rare as it has been considered in the past. 1,2 We present two leprosy patients who developed squamous cell carcinoma (SCC) in chronic trophic ulcers. This is the first report from Greece.…”

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confidence: 99%

Squamous cell carcinoma in chronic trophic ulcers of leprosy patients

Kontochristopoulos

Kyriakis

Symeonidou

et al. 2000

Acad Dermatol Venereol

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“…Dans les autres séries de la littérature, il s'agit le plus souvent de patients de sexe masculin atteints d'une lèpre tuberculoïde [5,7]. Dans notre série, la majorité de nos malades sont des multibacillaires : cela s'explique par la fréquence de la lèpre lépromateuse dans notre contexte.…”

Section: Discussionunclassified

“…Chez un malade, une double localisation a été retrouvée avec dégénérescence d'un ulcère chronique de la main et d'un MPP. La survenue de carcinome sur ulcère chronique du membre supérieur est décrite dans la littérature (surtout sur la paume de la main droite) [4] ; elle reste beaucoup plus rare que la localisation au niveau des membres inférieurs [4,7]. La mise en évidence d'un aspect pseudoépi-théliomateux à la biopsie cutanée ne doit pas faire éliminer le diagnostic de carcinome spinocellulaire.…”

Section: Discussionunclassified

Dégénérescence carcinomateuse des maux perforants plantaires d’origine lépreuse: expérience du Centre national de léprologie de Casablanca

Hali

Latifi²,

Sbai³

2010

Bull. Soc. Pathol. Exot.

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Malignant degeneration is a late complication of plantar ulcers in leprosy. The objective of this study is to describe and analyze the epidemiological, clinical, and therapeutic aspects of this complication in Morocco. A retrospective study was conducted from January 2000 to December 2009 at the National Center of Leprosy (CNL) in Casablanca. All our patients had a histological confirmation. Ten patients were included in this study. There were seven men and three women, with a mean age of 58.8 years. Six patients had a multibacillary form of leprosy and four had a paucibacillary form. The average duration of the plantar ulcers was 34.4 years. Clinical appearance at diagnosis was an ulcerative and vegetative tumor. Treatment was by radical amputation. Evolution was marked by metastatic spread in six patients. One patient died of disseminated disease. In Morocco, leprosy has been on the decline since 1990, but the occurrence of late complications in the leprosy patient as carcinoma of plantar ulcers persists. Prevention of these complications should be part of the national fight against leprosy.

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Squamous cell carcinoma in chronic ulcers in leprosy: a review of 38 consecutive cases

Cited by 20 publications

References 1 publication

Roles of the immune system in skin cancer

Roles of the immune system in skin cancer

Squamous cell carcinoma in chronic trophic ulcers of leprosy patients

Dégénérescence carcinomateuse des maux perforants plantaires d’origine lépreuse: expérience du Centre national de léprologie de Casablanca

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