Squamous Cell Carcinoma in Localized Scleroderma

Ďurčanská, Veronika; Jedličková, Hana; Sláma, Ondřej; Velecký, Lukáš; Březinová, Eva; Vašků, Vladimı́r

doi:10.14735/amko2014434

Cited by 5 publications

(1 citation statement)

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“…Although a malignant turn of localized scleroderma is rarely seen, Durcanska et al concluded that a young 26-year-old woman who was diagnosed with localized scleroderma (morphea) ultimately developed SCC camouflaged by osteomyelitis on the lower extremities after a long course of the disease [9]. An 18-year-old woman with progressive SSc developed SCC of the skin.…”

Section: Discussionmentioning

confidence: 99%

Development of Two Types of Skin Cancer in a Patient with Systemic Sclerosis: a Case Report and Overview of the Literature

Ulutaş

Çomut

Çobankara

2021

Case Reports in Oncological Medicine

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Systemic sclerosis (SSc) is an uncommon rheumatic disease in which the underlying main histopathologic feature is a thickening of the skin due to excessive accumulation of collagen in the extracellular tissue. Fibrogenesis, chronic inflammation, and ulceration may eventually promote skin neoplasms. Although nonmelanoma skin cancer (NMSC) is the most frequent type, there have been restricted case reports and case series with skin cancers in SSc patients in the literature. Herein, we describe a 78-year-old woman diagnosed with diffuse cutaneous systemic sclerosis thirteen years ago and associated nonspecific interstitial pneumonia that was successfully treated with high cumulative doses of cyclophosphamide. She developed basal cell carcinoma and squamous cell carcinoma of the skin in the follow-up. She is still on rituximab treatment with stable interstitial lung disease as indicated by pulmonary function tests and high-resolution chest computed tomography. To our knowledge and a literature search, this is the first reported patient with SSc with two types of skin cancer. In this review, we also aimed to emphasize the relationship between SSc and skin cancer, and possible risk factors for SSc-related skin cancer.

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Section: Discussionmentioning

confidence: 99%

Development of Two Types of Skin Cancer in a Patient with Systemic Sclerosis: a Case Report and Overview of the Literature

Ulutaş

Çomut

Çobankara

2021

Case Reports in Oncological Medicine

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Long‐standing morphea and the risk of squamous cell carcinoma of the skin

Heck

Olk

Kneitz

et al. 2020

J Deutsche Derma Gesell

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Summary Scleroderma is a heterogeneous group of fibrosing connective tissue disorders of unknown etiology. Morphea is a localized form of scleroderma that occasionally leads to chronic erosions and ulcerations of the skin. Fibrosis, inflammation and chronic ulcerations may eventually promote skin neoplasms; morphea is therefore a rare but established risk factor for cutaneous squamous cell carcinoma (cSCC). We present a review of 16 scleroderma patients: 15 case reports from the literature (identified by a PubMed search) and one case from our clinic of a patient who had developed cSCC, and we discuss potential underlying mechanisms. Statistical analysis revealed that the lower extremities were the body site most commonly affected by cSCC in these scleroderma patients. The mean time interval between the onset of scleroderma and the development of cSCC was ten to twenty years. In patients with morphea, we recommend checking for skin tumors during follow‐up examinations as well as a careful risk‐benefit analysis when considering the application of immunosuppressants or phototherapy in view of their potential carcinogenic side effects.

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Lang bestehende Morphea und das Risiko für Plattenepithelkarzinome der Haut

Heck

Olk

Kneitz

et al. 2020

J Deutsche Derma Gesell

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Zusammenfassung Der Begriff Sklerodermie umfasst eine heterogene Gruppe fibrosierender Bindegewebserkrankungen unbekannter Ätiologie. Die Morphea (Syn.: zirkumskripte Sklerodermie) ist eine umschriebene Form der Sklerodermie, die in einigen Fällen zu (chronischen) Erosionen und Ulzerationen betroffener Hautareale führen kann. Fibrosierung, Entzündung und chronische Ulzerationen können die Entwicklung von Hauttumoren begünstigen; die Morphea stellt daher einen seltenen, aber etablierten Risikofaktor für kutane Plattenepithelkarzinome (kPEK) dar. In der vorliegenden Arbeit präsentieren wir eine Übersicht von 16 Patienten mit Morphea (15 Fallberichte, die mittels systematischer Literaturrecherche in der Datenbank PubMed identifiziert wurden; einen Fall aus unserer Klinik), die ein kPEK entwickelt hatten, und wir diskutieren mögliche zugrunde liegende Mechanismen. Die statistische Analyse ergab, dass sich kPEK auf dem Boden einer Morphea am häufigsten an der unteren Extremität manifestieren. Im Durchschnitt vergingen zehn bis zwanzig Jahre zwischen dem Beginn der Morphea und der Entstehung eines kPEK. Bei Patienten mit Morphea sollte bei Nachuntersuchungen auf Hauttumoren geachtet werden. Vor dem Einsatz von Immunsuppressiva oder Phototherapien ist angesichts des karzinogenen Potenzials dieser Therapieformen eine sorgfältige Risiko‐Nutzen‐Abwägung angezeigt.

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Squamous Cell Carcinoma in Localized Scleroderma

Cited by 5 publications

References 0 publications

Development of Two Types of Skin Cancer in a Patient with Systemic Sclerosis: a Case Report and Overview of the Literature

Development of Two Types of Skin Cancer in a Patient with Systemic Sclerosis: a Case Report and Overview of the Literature

Long‐standing morphea and the risk of squamous cell carcinoma of the skin

Lang bestehende Morphea und das Risiko für Plattenepithelkarzinome der Haut

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