Squamous Cell Carcinoma in the Foot: Case Series and Literature Review

Abstract

Objectives:To report a case series of squamous cell carcinoma (SCC) in the foot, describing previous risk factors, surgical treatment, histopathological findings, and functional and oncological results. Methods:Nine consecutive patients diagnosed with SCC of the foot were treated at a single institution and prospectively analyzed for risk factors related to the disease, surgical outcome, and histopathological, functional and oncological results. All patients had identifiable risk factors for SCC. Results:Definitive treatment consisted of partial (6 patients) or total (3 patients) amputation of the foot. The functional score was good or excellent in the surviving patients. Early identifiable risk factors are present in most patients. Biopsy when this diagnosis is suspected, in association with oncological principles, avoids diagnostic and treatment errors. Conclusion:Despite delayed diagnosis and surgical treatment with partial and total amputations of the foot in our series, we observed good oncological outcomes that avoided systemic spread of the disease and achieved expected functional results. Level of Evidence V; Case series.

Squamous Cell Carcinoma with Co-infection of Microsphaeropsis arundinis and Geotrichum candidum: A Rare Case Report

“…This patient was consulted to the orthopedic department because of suspicion of bone invasion. In cases with difficult to distinguish borders, amputation may be performed, where complete excision of the tumor rarely results in recurrence [4]. The prognosis for verrucous carcinoma is generally good but local invasiveness and metastatic potential can occur [1].…”

“…This carcinoma in the plantar area can be irregular, well-defined, verrucous, and is also known as epithelioma cuniculatum. Management is usually palliative and includes extensive and aggressive tumor resection [4].…”

A Nonhealing Wound on the Right Heel

“…Virus infection, chemical exposure, chronic inflammation or irritation, mechanical stress, immunosuppressed status, or inherited traits are common causes of skin cancers on feet. [6][7][8][9] The most common skin malignancies on foot are basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and malignant melanoma. In general, cutaneous malignancies on the foot share several similar features: recurrence, painless, bleeding, and ulceration.…”

“…When presenting on foot, SCCs vary from irregular, slow-growing plaques to painful, odorous, infected ulcerations. 8 Melanoma on the hands and feet is named acral lentiginous melanoma (ALM). Unlike other subtypes of melanoma, ALM is dominate in non-White populations.…”

Trouble afoot: A review of common skin conditions of the feet and nails

“…foot, occurring on the dorsal, acral and subungual regions. 17 It occasionally arises from thermal burn scars, venous ulcers and osteomyelitic lesions known as Marjolin ulcers, which are often highly aggressive. 18 Although some of the presentations mentioned in this article can have considerable overlap in appearance, careful observation of the important key features combined with the correct investigations will enable an accurate diagnosis and the appropriate management.…”