Squamous cell carcinoma of the thyroid gland‐transition from adenocarcinoma

Harada, Tanekazu; Shimaoka, Katsutaro; Yakumaru, Kazuhiro; Ito, Kunihiko

doi:10.1002/jso.2930190111

Cited by 61 publications

(40 citation statements)

References 13 publications

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“…Which chemotherapeutic regimen is useful, remains obscure. There were attempts using adriamycin, bleomycin, cisplatin, nitrogen mustard, vincristine, AB-132, doxorubicin and cyclophosphamide providing no survival advantage [7,34]. The last 2 chemotherapeutics were of no value in our patient.…”

Section: Discussionmentioning

confidence: 88%

“…SCC may be found together with associated malignant and benign thyroid disease. Squamous metaplasia can be seen in papillary, follicular, medullary and anaplastic thyroid cancers [5,[7][8][9]. Among benign lesions, Hashimoto's thyroiditis can show squamous differentiation [24,25].…”

Section: Discussionmentioning

confidence: 99%

“…PRIMARY squamous cell carcinoma (SCC) of the thyroid is extremely rare, since there is no squamous epithelium in the thyroid tissue, except in some exceptional situations like embryologic remnants [1][2][3][4], inflammatory process [5][6] and cancers [5,[7][8][9]. This type of thyroid malignancy is seen less than 1% of all thyroid cancers and is highly lethal.…”

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confidence: 99%

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Primary Squamous Cell Carcinoma of the Thyroid: Report of Three Cases

et al. 2008

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Abstract. We report three cases of squamous cell carcinoma of the thyroid, which is an unusual malignant tumor that needs to be distinguished from other thyroid pathologies due to its aggressive behaviour. Three men, with an average of 63 years old, presented with progressive enlargement in the neck, hoarse voice or weight loss. Physical and radiological examinations revealed clues where malignancy was suspected and surgical resections were performed. Histopathological examination of the specimens was diagnosed as squamous cell carcinoma. Proper workup excluded the possibility of any primary site of SCC other than the thyroid. All patients died within 5 months. Adjuvant therapy evaluation is still inconclusive. Complete surgical resection still remains the primary choice for cure. We believe that radical resection with clear surgical margins followed by adjuvant chemo-radiation therapy is a curative strategy for achieving any chance of long-term survival.

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Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 99%

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Primary Squamous Cell Carcinoma of the Thyroid: Report of Three Cases

et al. 2008

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“…23,25 Nonetheless, the latter neoplasms show a greater degree of cytologic and histologic anaplasia than that seen in classical MEC.…”

Section: Discussionmentioning

confidence: 94%

Primary mucoepidermoid carcinoma of the thyroid: Diagnosis by fine‐needle aspiration biopsy

Larson

Wick

1993

Diagnostic Cytopathology

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Fine-needle aspiration biopsy (FNAB) has been recognized as a safe and reliable procedure in the evaluation of thyroid nodules. We herein report a case of a low-grade mucoepidermoid carcinoma of the thyroid that was diagnosed with this technique. Examination of an intra-operative FNAB showed cohesive clusters of polygonal squamoid cells with distinct cellular borders, uniform round nuclei, distinct nucleoli, and homogeneous amphophilic to cyanophilic cytoplasm. Focal keratin "pearl" formation was apparent, along with extracellular, lightly basophilic mucin deposits mantled by squamoid cells. These cytologic features are characteristic of low-grade mucoepidermoid carcinoma, as seen in other anatomic sites. This impression was confirmed by examination of paraffin sections. Previous reports have indicated that mucoepidermoid thyroid carcinoma is an indolent, locally recurring lesion. However, in spite of low-grade histology in our case, the neoplasm presented with distant metastases to bones, pleura, and lung.

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“…7 It follows a very aggressive clinical course, and is thus considered to be a form of anaplastic or undifferentiated carcinoma. In most cases, there is a coexisting adenocarcinoma or undifferentiated carcinoma.…”

Section: Discussionmentioning

confidence: 99%

Metastatic Papillary Thyroid Carcinoma of the Submandibular Lymph Nodes with Extensive Squamous Metaplasia: Report of a Case

et al. 2003

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We report a unique case of metastatic papillary thyroid carcinoma of the submandibular lymph nodes with extensive squamous metaplasia. A 48-year-old man was referred to our hospital for treatment of a thyroid tumor and right submandibular masses. A tumor, 2 cm in its largest dimension, was palpated in the right lobe of the thyroid gland. The masses in the submandibular region measured up to 3 cm in diameter. Each submandibular tumor had a cystic cavity containing slightly opaque fluid. Aspiration cytology of the thyroid established a diagnosis of papillary carcinoma. Aspirated material from the cystic cavity of one of the submandibular masses contained only keratinized material with a thyroglobulin level of 175 ng/ml. The patient underwent a total thyroidectomy with modified radical neck dissection. Microscopic examination of the resected specimen confirmed a diagnosis of papillary carcinoma of the thyroid, as well as well-differentiated squamous cell carcinoma with cystic changes in the submandibular lymph nodes. Focal immunoreactivity for thyroglobulin, combined with the absence of any other possible primary lesions in the head and neck region, suggested metastatic papillary thyroid carcinoma of the submandibular lymph nodes with extensive squamous metaplasia.

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Squamous cell carcinoma of the thyroid gland‐transition from adenocarcinoma

Cited by 61 publications

References 13 publications

Primary Squamous Cell Carcinoma of the Thyroid: Report of Three Cases

Primary Squamous Cell Carcinoma of the Thyroid: Report of Three Cases

Primary mucoepidermoid carcinoma of the thyroid: Diagnosis by fine‐needle aspiration biopsy

Metastatic Papillary Thyroid Carcinoma of the Submandibular Lymph Nodes with Extensive Squamous Metaplasia: Report of a Case

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