Squamous cell carcinoma transformation in mature cystic teratoma of the ovary: a systematic review

Li, Congcong; Zhang, Qing; Zhang, Siying; Dong, Ruifen; Sun, Ce; Qiu, Chunping; Zhang, Zhiwei; Yang, Xinggang; Kong, Beihua

doi:10.1186/s12885-019-5393-y

“…[4, 13] Several studies suggested that chemotherapy with BEP can be used in ovarian SCC. [14] Nevertheless our patient had a poor effect to the chemotherapy with BEP, which may lead to the recurrence within a short period of time.…”

Section: Discussionmentioning

confidence: 69%

Recurrence of ovarian squamous cell carcinoma with MET gene copy number variation: a case report and review of literature

Dong

¹

,

Yuan

²

,

Yao³

2020

Preprint

0

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Background: Malignant transformation such as ovarian squamous cell carcinoma (SCC) in ovarian mature cystic teratoma (OMCT) is a rare tumor. The gene mutation of ovarian SCC remains unclear. We herein report a recurrent case of ovarian squamous cell carcinoma with MET gene copy number variation. Case presentation: A 60-year-old woman presented with recurrence of ovarian SCC 8 months after primary surgery. Adhesiolysis, right abdominal wall mass excision, prosthetics, enterectomy, enterostomy and partial cystectomy were performed by laparoscope. Pathologic examination demonstrated metastatic squamous cell carcinoma in ileocecus, rectum and abdominal wall muscle. MET gene copy number was elevated with copy number of six in this case. Postoperatively, the patient was treated with four cycles of combination chemotherapy with docetaxel and carboplatin. The patient was free of disease at 20 months’ follow-up. Conclusions: Optimal cytoreductive surgery combined with platinum-based chemotherapy is recommended currently for not only primary tumor but also recurrence. For patients with malignant transformation in OMCT, prompt diagnosis and individualized treatment are crucial for better prognosis. Increased copy number of MET may be correlated with her poor PFS and can be a potential therapeutic target for this case.

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“…[4,13] Several studies suggested that chemotherapy with BEP can be used in ovarian SCC. [14] Nevertheless our patient had a poor effect to the chemotherapy with BEP, which may lead to the recurrence within a short period of time.…”

Section: Treatment Of Ovarian Sccmentioning

confidence: 69%

Recurrence of ovarian squamous cell carcinoma with MET gene copy number variation: a case report and review of literature

Dong

¹

,

Yuan

²

,

Yao

³

2020

Preprint

0

View full text Add to dashboard Cite

Background: Malignant transformation such as ovarian squamous cell carcinoma (SCC) in ovarian mature cystic teratoma (OMCT) is a rare tumor. The gene mutation of ovarian SCC remains unclear. We herein report a recurrent case of ovarian squamous cell carcinoma with MET gene copy number variation. Case presentation: A 60-year-old woman presented with recurrence of ovarian SCC 8 months after primary surgery. Adhesiolysis, right abdominal wall mass excision, prosthetics, enterectomy, enterostomy and partial cystectomy were performed by laparoscope. Pathologic examination demonstrated metastatic squamous cell carcinoma in ileocecus, rectum and abdominal wall muscle. MET gene copy number was elevated with copy number of six in this case. Postoperatively, the patient was treated with four cycles of combination chemotherapy with docetaxel and carboplatin. The patient was free of disease at 20 months’ follow-up. Conclusions: Optimal cytoreductive surgery combined with platinum-based chemotherapy is recommended currently for not only primary tumor but also recurrence. For patients with malignant transformation in OMCT, prompt diagnosis and individualized treatment are crucial for better prognosis. Increased copy number of MET may be correlated with her poor PFS and can be a potential therapeutic target for this case.

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“…Surgery is the recommended course of treatment for primary colorectal SCC. In cases of ovarian teratomas with malignant transformation, hysterectomy can improve overall survival and was performed in our case [26]. A preoperative combined CRT can be performed in rectal SCC for improved local disease control.…”

Section: Discussionmentioning

confidence: 84%

Diagnostically challenging human papillomavirus-associated primary squamous cell carcinoma of the rectum with metastasis in both ovaries: a case report

Tschann

¹

,

Lechner

²

,

Feurstein

³

et al. 2020

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Introduction: Squamous cell carcinomas of the rectum are extremely rare and their pathogenesis is still under debate. Their proper diagnosis and treatment may thus be challenging. Case presentation: A 52-year-old Caucasian woman was transferred to our department with a history of pelvic pain. Colonoscopy revealed a small tumorous lesion of the upper rectum and an endoscopic biopsy showed infiltration of the rectal mucosa by a squamous cell carcinoma. Afterward, tumorous lesions were found on imaging in both her ovaries. A laparoscopy with adnexectomy and anal mapping was performed and revealed tumor masses of squamous cell carcinoma in both ovaries. Based on the large size of the ovarian tumors and the concurrence of extensive, partly ciliated, macrocystic epithelium in one of the ovaries, a diagnosis of ovarian squamous cell carcinoma arising from a mature teratoma was rendered. However, human papillomavirus genotyping analyses were positive for human papillomavirus-16 in both the rectal tumor and ovarian tumors leading to a final diagnosis of a human papillomavirus-associated rectal squamous cell carcinoma metastatic to both ovaries. Neoadjuvant chemoradiation therapy of her rectum, total mesorectal excision, and hysterectomy were performed followed by adjuvant chemotherapy. Conclusion: Colorectal squamous cell carcinoma is a rare disease. In cases of colorectal squamous cell carcinoma, metastatic disease at any other location has to be excluded. Human papillomavirus genotyping is essential in this context. Discussion of the treatment strategies should be interdisciplinary and include chemoradiation therapy and radical surgery.

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Squamous cell carcinoma transformation in mature cystic teratoma of the ovary: a systematic review

Cited by 66 publications

References 104 publications

Recurrence of ovarian squamous cell carcinoma with MET gene copy number variation: a case report and review of literature

Recurrence of ovarian squamous cell carcinoma with MET gene copy number variation: a case report and review of literature

Recurrence of ovarian squamous cell carcinoma with MET gene copy number variation: a case report and review of literature

Diagnostically challenging human papillomavirus-associated primary squamous cell carcinoma of the rectum with metastasis in both ovaries: a case report

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