Squaring the circle: circRNAs in melanoma

Mecozzi, Nicol; Vera, Olga; Karreth, Florian A.

doi:10.1038/s41388-021-01977-1

Cited by 14 publications

(6 citation statements)

References 97 publications

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“…Recent studies have demonstrated that circRNAs have an important role in disease progression by mediating expressions of their linear transcripts ( Wu et al, 2020 ; Tang et al, 2021 ; Mecozzi et al, 2021 ; Peng and Wang, 2021 ). Through qRT-PCR and rescue experiments, we found that hsa_circ_0062270 was able to stabilize the expression of its linear transcript CDC45.…”

Section: Discussionmentioning

confidence: 99%

Hsa_circ_0062270 Promotes Tumorigenesis of Melanoma by Stabilizing the Linear Transcript Cell Division Cycle Protein 45

et al. 2022

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Background: To elucidate the potential biological function of hsa_circ_0062270 in the malignant process of melanoma and its potential target.Methods: Quantitative real-time polymerase chain reaction (qRT-PCR) was conducted to examine relative level of hsa_circ_0062270 in melanoma tissues and normal skin tissues. The diagnostic and prognostic potentials of hsa_circ_0062270 in melanoma were evaluated. The regulatory effect of hsa_circ_0062270 on the expression of linear transcript Cell division cycle protein 45 (CDC45) was also examined.Results: Hsa_circ_0062270 was up-regulated in melanoma samples and cell lines, which displayed certain diagnostic and prognostic potentials in melanoma. Inhibition of hsa_circ_0062270 attenuated the proliferative, migratory and invasive functions. Hsa_circ_0062270 could stabilize the expression of linear transcript CDC45, and thus participated in the malignant process of melanoma.Conclusion: Hsa_circ_0062270 promotes proliferative, migratory and invasive functions of melanoma cells via stabilizing the linear transcript CDC45. Hsa_circ_0062270 can be used to diagnosis and treatment of melanoma.

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Section: Discussionmentioning

confidence: 99%

Hsa_circ_0062270 Promotes Tumorigenesis of Melanoma by Stabilizing the Linear Transcript Cell Division Cycle Protein 45

et al. 2022

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“…N 6 -methyladenosine (m 6 A) modification can promote the translation of circRNAs into small peptides and this process can be carried out in a way that does not rely on the 5' cap (120). M 6 A modification is an epigenetic modification that widely exists in circRNAs, and plays an important role in regulating gene expression, splicing, RNA editing, RNA stability and controlling mRNA longevity and degradation (121,122). However, most circRNAs originate from the back splicing of exons, which may cause the corresponding mRNA level to decrease.…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

“…Following the extensive studies of long noncoding RNAs (lncRNAs) and microRNAs (miRNAs) in various diseases (1)(2)(3), circular RNAs (circRNAs), another important member of the non-coding RNAs (ncRNAs) family, have also been found to be widely involved in tumors and other diseases and have been exhibited to be valuable diagnostic and prognostic biomarkers (4)(5)(6).…”

Section: Introductionmentioning

confidence: 99%

Emerging landscape of circFNDC3B and its role in human malignancies

et al. 2023

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In recent years, more attention has been paid to expanding the abundance of Circular RNAs (circRNAs), while the circRNAs that have been found to have significant functions have not been studied in different diseases. CircFNDC3B is one of the most researched circRNAs generated from fibronectin type III domain-containing protein 3B (FNDC3B) gene. Accumulating researches have reported the multiple functions of circFNDC3B in different cancer types and other non-neoplastic diseases, and predicted that circFNDC3B might be a potential biomarker. Notably, circFNDC3B can play roles in different diseases by binding to various microRNAs (miRNAs), binding to RNA-binding proteins (RBPs), or encoding functional peptides. This paper systematically summarizes the biogenesis and function of circRNAs, reviews and discusses the roles and molecular mechanisms of circFNDC3B and its target genes in different cancers and non-neoplastic diseases, which will do favor to broaden our comprehension of the function of circRNAs and facilitate subsequent research on circFNDC3B.

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“…To date, only circ_0084043, circ_0020710, and circ_0016418 have been demonstrated to function as oncogenes in melanoma in immunocompromised mice [109][110][111][112][113][114]. Given their low expression in normal tissues, several lncRNAs are regarded as promising melanoma biomarkers (reviewed in [115]) (Figure 1).…”

Section: Oncogenic Lncrnas In Melanomamentioning

confidence: 99%

Regulation of LncRNAs in Melanoma and Their Functional Roles in the Metastatic Process

Melixetian

Pelicci

Lanfrancone

2022

Cells

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Long non-coding RNAs (lncRNAs) are key regulators of numerous intracellular processes leading to tumorigenesis. They are frequently deregulated in cancer, functioning as oncogenes or tumor suppressors. As they act through multiple mechanisms, it is not surprising that they may exert dual functions in the same tumor. In melanoma, a highly invasive and metastatic tumor with the propensity to rapidly develop drug resistance, lncRNAs play different roles in: (i) guiding the phenotype switch and leading to metastasis formation; (ii) predicting the response of melanoma patients to immunotherapy; (iii) triggering adaptive responses to therapy and acquisition of drug resistance phenotypes. In this review we summarize the most recent findings on the lncRNAs involved in melanoma growth and spreading to distant sites, focusing on their role as biomarkers for disease diagnosis and patient prognosis, or targets for novel therapeutic approaches.

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Squaring the circle: circRNAs in melanoma

Cited by 14 publications

References 97 publications

Hsa_circ_0062270 Promotes Tumorigenesis of Melanoma by Stabilizing the Linear Transcript Cell Division Cycle Protein 45

Hsa_circ_0062270 Promotes Tumorigenesis of Melanoma by Stabilizing the Linear Transcript Cell Division Cycle Protein 45

Emerging landscape of circFNDC3B and its role in human malignancies

Regulation of LncRNAs in Melanoma and Their Functional Roles in the Metastatic Process

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