Squid Ring Teeth–coated Mesh Improves Abdominal Wall Repair

Leberfinger, Ashley N.; Hospodiuk, Monika; Pena‐Francesch, Abdon; Ayan, Bugra; Özbolat, Veli; Koduru, Srinivas; Özbolat, İbrahim T.; Demirel, Melik C.; Ravnic, Dino J.

doi:10.1097/gox.0000000000001881

Cited by 11 publications

(11 citation statements)

References 26 publications

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“…Histological staining showed moderate inflammatory response and prominent collagen deposition anterior to the SRT-PP mesh, which was corroborated by increased ultimate strength. But there were no elastin staining or quantification revealed that the SRT-PP mesh is less stiff (more elastic) than the PP mesh . Especially, the SRT-PP mesh tends to form the stiff collagen-rich scar with the encapsulation of undegraded PP other than the mature connective tissue after remodeling.…”

Section: Functional Meshesmentioning

confidence: 99%

“…But there were no elastin staining or quantification revealed that the SRT-PP mesh is less stiff (more elastic) than the PP mesh. 46 Especially, the SRT-PP mesh tends to form the stiff collagen-rich scar with the encapsulation of undegraded PP other than the mature connective tissue after remodeling. The investigation of the mechanics of SRT-biologic mesh is expected in further study.…”

Section: Functional Meshesmentioning

confidence: 99%

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Functionalized Strategies and Mechanisms of the Emerging Mesh for Abdominal Wall Repair and Regeneration

Liu

Wei

2021

ACS Biomater. Sci. Eng.

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Meshes have been the overwhelmingly popular choice for the repair of abdominal wall defects to retrieve the bodily integrity of musculofascial layer. Broadly, they are classified into synthetic, biological and composite mesh based on their mechanical and biocompatible features. With the development of anatomical repair techniques and the increasing requirements of constructive remodeling, however, none of these options satisfactorily manages the conditional repair. In both preclinical and clinical studies, materials/agents equipped with distinct functions have been characterized and applied to improve meshaided repair, with the importance of mesh functionalization being highlighted. However, limited information exists on systemic comparisons of the underlying mechanisms with respect to functionalized strategies, which are fundamental throughout repair and regeneration. Herein, we address this topic and summarize the current literature by subdividing common functions of the mesh into biomechanics-matched, macrophage-mediated, integrationenhanced, anti-infective and antiadhesive characteristics for a comprehensive overview. In particular, we elaborate their effects separately with respect to host response and integration and discuss their respective advances, challenges and future directions toward a clinical alternative. From the vastly different approaches, we provide insight into the mechanisms involved and offer suggestions for personalized modifications of these emerging meshes.

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Section: Functional Meshesmentioning

confidence: 99%

Section: Functional Meshesmentioning

confidence: 99%

Functionalized Strategies and Mechanisms of the Emerging Mesh for Abdominal Wall Repair and Regeneration

Liu

Wei

2021

ACS Biomater. Sci. Eng.

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“…(b) Pre-coating and (c) post-coating images show a homogeneous coating around individual polypropylene fibers. Reproduced with permission (Leberfinger et al, 2018). (d) Multilayer biomolecule encapsulation (enzymes), providing built-in detection and protection against hazardous agents.…”

Section: Srt Based Films In Textile Applicationsmentioning

confidence: 99%

Squid-Inspired Tandem Repeat Proteins: Functional Fibers and Films

Pena‐Francesch

Demirel

2019

Front. Chem.

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Production of repetitive polypeptides that comprise one or more tandem copies of a single unit with distinct amorphous and ordered regions have been an interest for the last couple of decades. Their molecular structure provides a rich architecture that can micro-phase-separate to form periodic nanostructures (e.g., lamellar and cylindrical repeating phases) with enhanced physicochemical properties via directed or natural evolution that often exceed those of conventional synthetic polymers. Here, we review programmable design, structure, and properties of functional fibers and films from squid-inspired tandem repeat proteins, with applications in soft photonics and advanced textiles among others.

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“…This hard biological material is mainly composed of a group of semicrystalline proteins ranging from 18 to 55 kDa in size. − Recently, SRT proteins from diverse species have been sequenced, enabling the analysis of their amino acid sequence and the heterologous expression of recombinant and synthetic SRT proteins in host organisms (e.g., genetically modified Escherichia coli bacteria). , Because of their outstanding physical properties (mechanical, thermal, conducting, etc. ), these squid proteins and their bioengineered derivatives (recombinant and synthetic proteins) are finding applications in biological and nonbiological applications, from medical devices , to biophotonic sensors and flexible electronics . Recent research efforts have shed light on the role of amino acid composition, nanostructure, and network topology on the physical properties of novel SRT-inspired proteins.…”

Section: Introductionmentioning

confidence: 99%

Diffusive Dynamic Modes of Recombinant Squid Ring Teeth Proteins by Neutron Spectroscopy

et al. 2022

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Stimuli-responsive structural proteins are emerging as promising biocompatible materials for a wide range of biological and nonbiological applications. To understand the physical properties of structural proteins and to replicate their performance in biosynthetic systems, there is a need to understand the molecular mechanisms and relationships that regulate their structure, dynamics, and properties.Here, we study the dynamics of a recombinant squid-inspired protein from Loligo vulgaris (Lv18) by elastic and quasielastic neutron scattering (QENS) to understand the connection between nanostructure, chain dynamics, and mechanical properties. Lv18 is a semicrystalline structural protein, which is plasticized by water above its glass transition temperature at 35 °C. Elastic scans revealed an increased protein chain mobility upon hydration, superimposed dynamic processes, and a decrease in dynamic transition temperatures. Further analysis by QENS revealed that while dry Lv18 protein dynamics are dominated by localized methyl group rotations, hydrated Lv18 dynamics are dominated by the confined diffusion of flexible chains within a β-sheet nanocrystalline network (8 Å of confinement radius). Our findings establish a relationship between the segment block architecture of Lv18, the diffusive motions within the protein structure, and the mechanical properties of recombinant squid proteins, which will advance the molecular design of novel high-performance protein-inspired materials with tailored dynamics and mechanical properties.

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Squid Ring Teeth–coated Mesh Improves Abdominal Wall Repair

Abstract: Supplemental Digital Content is available in the text.

Cited by 11 publications

References 26 publications

Functionalized Strategies and Mechanisms of the Emerging Mesh for Abdominal Wall Repair and Regeneration

Functionalized Strategies and Mechanisms of the Emerging Mesh for Abdominal Wall Repair and Regeneration

Squid-Inspired Tandem Repeat Proteins: Functional Fibers and Films

Diffusive Dynamic Modes of Recombinant Squid Ring Teeth Proteins by Neutron Spectroscopy

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