Citation: Bataille, C. P., J. Laffoon, and G. J. Bowen. 2012. Mapping multiple source effects on the strontium isotopic signatures of ecosystems from the circum-Caribbean region. Ecosphere 3 (12) Sr from the circum-Caribbean region (Antilles and Mesoamerica). Although the bedrock-only method performs relatively well in Mesoamerica (n ¼ 99, MAE ¼ 0.00011, RMSE ¼ 0.00073), its prediction accuracy is lower for the Antillean dataset (n ¼ 287, MAE ¼ 0.0021, RMSE ¼ 0.0027). In comparison, the new multiple source model, which accounts for the deposition of sea salt and mineral dust aerosols, performs comparably well in predicting the observed 87 Sr/ 86 Sr values in both datasets (MAE ¼ 0.00040, RMSE ¼ 0.00087 and MAE ¼ 0.00014, RMSE ¼ 0.0010). This study underscores the potential of using process-oriented spatial modeling to improve the predictive power of Sr isoscapes over large spatial scales and to refine sampling strategies and bioavailable Sr dataset interpretations for provenance studies.