SSeCKS/AKAP12 induces repulsion between human prostate cancer and microvessel endothelial cells through the activation of Semaphorin 3F

Xie, Wen; Su, Wei; Zhang, Lijuan; Shang, Qingkun; Su, Bing

doi:10.1016/j.bbrc.2017.07.043

Cited by 9 publications

(3 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[14,15] However, the mechanisms of prostate cancer metastasis are poorly understood. [14,15] However, the mechanisms of prostate cancer metastasis are poorly understood.…”

Section: Discussionmentioning

confidence: 99%

Retracted: Knockdown of SRPX2 inhibits the proliferation, migration, and invasion of prostate cancer cells through the PI3K/Akt/mTOR signaling pathway

2018

J Biochem & Molecular Tox

View full text Add to dashboard Cite

Sushi repeat‐containing protein X‐linked 2 (SRPX2), a novel chondroitin sulfate proteoglycan, is reported to play a critical role in tumorigenesis. However, the expression and functional role of SRPX2 in prostate cancer have not been defined. Thus, the aim of this study was to investigate the expression and functional role of SRPX2 in human prostate cancer. Our results showed that the expression of SRPX2 was obviously increased in human prostate cancer tissues and cell lines. In addition, knockdown of SRPX2 inhibited the proliferation, migration, and invasion of prostate cancer cells, as well as prevented the epithelial‐mesenchymal transition process in prostate cancer cells. Mechanically, knockdown of SRPX2 efficiently inhibited the activation of PI3K/Akt/mTOR pathway in prostate cancer cells. Taken together, these data demonstrated that knockdown of SRPX2 inhibits the proliferation and metastasis in human prostate cancer cells, partly through the PI3K/Akt/mTOR signaling pathway. Thus, SRPX2 may be a novel therapeutic target for the treatment of prostate cancer.

show abstract

“…[14,15] However, the mechanisms of prostate cancer metastasis are poorly understood. [14,15] However, the mechanisms of prostate cancer metastasis are poorly understood.…”

Section: Discussionmentioning

confidence: 99%

Retracted: Knockdown of SRPX2 inhibits the proliferation, migration, and invasion of prostate cancer cells through the PI3K/Akt/mTOR signaling pathway

2018

J Biochem & Molecular Tox

View full text Add to dashboard Cite

show abstract

“…Previous studies have demonstrated that SEMA3F played a role as a tumor suppressor in prostate and other cancers. Xie Wen et al found that the degree of PCa aggressiveness was inversely associated with the AKAP12 and SEMA3F expression [21]. Bielenberg et al demonstrated that SEMA3F was markedly downregulated in highly metastatic human cell lines in vitro and in vivo, and then transfected metastatic human melanoma cells with SEMA3F and implanted the melanoma cells into mice.…”

Section: Discussionmentioning

confidence: 99%

Clinical relevance of semaphorin-3F in patients with prostate cancer

2019

CIM

View full text Add to dashboard Cite

Purpose: To identify prognosis predictors for patients with prostate cancer (PCa). Methods: Four independent PCa microarray datasets (GSE32448, GSE16560, GSE79957 and GSE17951) were reanalyzed to characterize the expression of semaphorin-3F (SEMA3F) gene between PCa patients and normal prostate tissues and the correlation between SEMA3F expression and the age, tumor/nodes/metastasis (TNM) staging, Gleason Grade Group, prostate-specific antigen level and overall survival of PCa patients. Gene set enrichment analysis was applied to investigate the potential relevant mechanisms regarding the expression of SEMA3F and the proliferation of PCa cells. Results: The level of SEMA3F was significantly higher in normal prostate tissues compared with that in PCa cells (P

show abstract

“…80 AKAP12 has been reported to suppress invasion, metastasis and cancer recurrence by inducing heterotypic repulsion between human prostate cancer and microvessel endothelial cells, inhibiting VEGF expression and enhancing soluble anti-angiogenic factors. 81 , 82 The combined loss of AKAP12 and Rb in the prostate leads to early metastasis to the lymph node in prostate cancer. 83 By inducing AKAP12 promoter demethylation and then increasing the expression of AKAP12, peroxisome proliferator-activated receptor gamma 2 (PPARG2) inhibits cell migration, colony formation, and invasion of prostate cancer cells in vitro.…”

Section: Role Of Akap12 In Various Cancersmentioning

confidence: 99%

Physiologic and pathophysiologic roles of AKAP12

2022

Science Progress

View full text Add to dashboard Cite

A kinase anchoring protein (AKAP) 12 is a scaffolding protein that improves the specificity and efficiency of spatiotemporal signal through assembling intracellular signal proteins into a specific complex. AKAP12 is a negative mitogenic regulator that plays an important role in controlling cytoskeletal architecture, maintaining endothelial integrity, regulating glial function and forming blood-brain barrier (BBB) and blood retinal barrier (BRB). Moreover, elevated or reduced AKAP12 contributes to a variety of diseases. Complex connections between AKAP12 and various diseases including chronic liver diseases (CLDs), inflammatory diseases and a series of cancers will be tried to delineate in this paper. We first describe the expression, distribution and physiological function of AKAP12. Then we summarize the current knowledge of different connections between AKAP12 expression and various diseases. Some research groups have found paradoxical roles of AKAP12 in different diseases and further confirmation is needed. This paper aims to assess the role of AKAP12 in physiology and diseases to help lay the foundation for the design of small molecules for specific AKAP12 to correct the pathological signal defects.

show abstract

SSeCKS/AKAP12 induces repulsion between human prostate cancer and microvessel endothelial cells through the activation of Semaphorin 3F

Cited by 9 publications

References 19 publications

Retracted: Knockdown of SRPX2 inhibits the proliferation, migration, and invasion of prostate cancer cells through the PI3K/Akt/mTOR signaling pathway

Retracted: Knockdown of SRPX2 inhibits the proliferation, migration, and invasion of prostate cancer cells through the PI3K/Akt/mTOR signaling pathway

Clinical relevance of semaphorin-3F in patients with prostate cancer

Physiologic and pathophysiologic roles of AKAP12

Contact Info

Product

Resources

About