St-elevation myocardial infarction as a first event—sex- and age-related mortality

Fischer, Alicia Jeanette; Feld, Jannik; Makowski, Lena; Engelbertz, Christiane; Kühnemund, Leonie; Günster, Christian; Dröge, Patrik; Ruhnke, Thomas; Gerß, Joachim; Freisinger, Eva; Reinecke, Holger; Köppe, Jeanette

doi:10.3238/arztebl.m2022.0161

Cited by 2 publications

(1 citation statement)

References 21 publications

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“…However, the proportion of men in all patients suffering a STEMI in Germany is about 70%. 25 This may explain the imbalance in sex distribution in the present study, at least in part.…”

Section: Discussionmentioning

confidence: 62%

Intermittent Fasting After ST-Segment–Elevation Myocardial Infarction Improves Left Ventricular Function: The Randomized Controlled INTERFAST-MI Trial

Dutzmann,

Kefalianakis,

Kahles

et al. 2024

Circ: Heart Failure

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BACKGROUND: Intermittent fasting has shown positive effects on numerous cardiovascular risk factors. The INTERFAST-MI trial (Intermittent Fasting in Myocardial Infarction) has been designed to study the effects of intermittent fasting on cardiac function after STEM (ST-segment–elevation myocardial infarction) and the feasibility of future multicenter trials. METHODS: The INTERFAST-MI study was a prospective, randomized, controlled, nonblinded, single-center investigator-initiated trial. From October 1, 2020, to July 15, 2022, 48 patients were randomized to the study groups intermittent fasting or regular diet and followed for 6 months with follow-up visits at 4 weeks and 3 months. RESULTS: In all, 22 of 24 patients in the intermittent fasting group with a mean age of 58.54±12.29 years and 20 of 24 patients in the regular diet group with a mean age of 59.60±13.11 years were included in the intention-to-treat population. The primary efficacy end point (improvement in left ventricular ejection fraction after 4 weeks) was significantly greater in the intermittent fasting group compared with the control group (mean±SD, 6.636±7.122%. versus 1.450±4.828%; P =0.038). This effect was still significant and even more pronounced after 3 and 6 months. The patients in the intermittent fasting group showed a greater reduction in diastolic blood pressure and body weight compared with the control group. The mean adherence of patients in the intermittent fasting group was a median of 83.7% (interquartile range, 69.0%–98.4%) of all days. None of the patients from either group reported dizziness, syncope, or collapse. CONCLUSIONS: Our results suggest that intermittent fasting after myocardial infarction may be safe and could improve left ventricular function after STEMI. REGISTRATION: URL: https://www.drks.de ; Unique identifier: DRKS00021784.

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“…However, the proportion of men in all patients suffering a STEMI in Germany is about 70%. 25 This may explain the imbalance in sex distribution in the present study, at least in part.…”

Section: Discussionmentioning

confidence: 62%