ST-segment depression in hypertensive patients is linked to elevations in blood pressure, pulse pressure and double product by 24-h Cardiotens monitoring

Uen, Sakir; Baulmann, Johannes; Düsing, Rainer; Glänzer, K; Vetter, Hans; Mengden, Thomas

doi:10.1097/00004872-200305000-00023

Cited by 36 publications

(32 citation statements)

References 32 publications

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“…A previous study has reported that ST-segment depressions occurred when DP increased from 10,900 (24-h mean) to 14,500 mmHg bpm (during ST-depression) in hypertensive patients (6). In the present study, the number of subjects, whose SAC was equal to or over 14,500 mmHg bpm, appears to have increased with increasing exercise work rate (Fig.…”

Section: Fig 5 Relationships Between Systemic Arterial Compliance (supporting

confidence: 65%

“…Increase in blood pressure and double product (DP: systolic blood pressure [SBP] × heart rate [HR]; an index of myocardial oxygen consumption) as evaluated by 24-h Cardiotens monitoring are demonstrably important determinants of STsegment depression in hypertensive older humans (6). Myocardial oxygen consumption increases during exercise because cardiac output and blood pressure increase.…”

Section: Introductionmentioning

confidence: 99%

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Age-Related Reduction of Systemic Arterial Compliance Induces Excessive Myocardial Oxygen Consumption during Sub-Maximal Exercise

Otsuki

Maeda

Kesen³

et al. 2006

Hypertens Res

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Reduction of systemic arterial compliance (SAC) with aging increases left ventricular afterload. The present study was designed to examine whether age-related reduction of SAC is related to excessive myocardial oxygen consumption during sub-maximal aerobic exercise. We studied elderly (60-69 years; n =25) and senior (70-82 years; n =25) subjects. We measured SAC immediately before the start of the ramp-fashion exercise (i.e., at the end of the 20 W warm-up exercise) and the double product (DP: systolic blood pressure heart rate) during the ramp-fashion exercise (20-50 W). SAC was significantly lower in senior subjects

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Section: Fig 5 Relationships Between Systemic Arterial Compliance (supporting

confidence: 65%

Section: Introductionmentioning

confidence: 99%

Age-Related Reduction of Systemic Arterial Compliance Induces Excessive Myocardial Oxygen Consumption during Sub-Maximal Exercise

Otsuki

Maeda

Kesen³

et al. 2006

Hypertens Res

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show abstract

“…However, also in that study this association did not remain significant when ambulatory BP data were included in the regression model. A combined elevation of heart rate and pulse pressure has been found to be an important predictor of myocardial ischaemia [42] and cardiovascular mortality [43]. In our sample, the ambulatory heart rate-pulse pressure product was an independent predictor of the future SBP level in the multivariable model.…”

Section: Discussionmentioning

confidence: 53%

Heart rate as a predictor of development of sustained hypertension in subjects screened for stage 1 hypertension: the HARVEST Study

Palatini

Dorigatti

Zaetta

et al. 2006

Journal of Hypertension

124

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“…this is because earlier studies among subjects with ischemic heart disease have found raised RPP to be associated with silent myocardial ischemia, and increased risk for acute myocardial ischemia and cardiovascular mortality. 10,20 One of the limitations of this study is the fact that we could not assess Nt-BNP in all the subjects because of limited funds for the study.…”

Section: Resultsmentioning

confidence: 99%

The significance of rate pressure product in heart failure patients

Karaye

Akintunde

2015

ICFJ

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Introduction: The rate pressure product (RPP) is a strong determinant of myocardial oxygen consumption, and relates strongly to important indices for morbidity and cardiovascular mortality. Its significance in Black-African subjects with heart failure (HF) has however not been well described. This study therefore aimed to assess the significance of RPP among admitted HF patients in 2 Nigerian centres.Methods: Admitted HF patients in the 2 centres were serially recruited after satisfying all inclusion criteria. RPP was calculated by multiplying heart rate by systolic blood pressure at admission. Subjects were classified into 2 groups based on RPP <10,000 (log10 <4.0) (group 1) or above (group 2), which is a cut-off value above which there is increased risk of myocardial ischemia.Results: 100 subjects were recruited from the 2 centres with a mean age of 47.3+/-19.5 years, and 53% were females. 35% of the subjects were in group 1 while 65% were in group 2. N-Terminal B-type Natriuretic Peptide (NTBNP), serially measured in only 37 subjects (12 in group 1; 25 in group 2), was significantly higher in group 1 as compared with group 2 (p=0.016). Group 1 also had lower interventricular septal thickness(IVST) (p=0.007) as compared with group 2 subjects. RPP correlated strongly with IVST (r=+0.510, p<0.001), left ventricular posterior wall thickness (LVPWT) (r=+0.399, p<0.001) and LV end-diastolic dimension (LVEDD) (r=-0.202, p=0.045). Log10 >4.0 was strongly associated with IVST (95%confidence interval (CI): 1.061-1.528, p=0.009) and NT-BNP (CI:0.999-1.000, p=0.026). There was however no significant relationship (p>0.05) between RPP and in-hospital mortality, severity of dyspnoea, gender, age, body weight, LV ejection fraction or presence of atrial fibrillation/flutter.Conclusion: This study confirms the close relationship that exists between a determinant of myocardial oxygen consumption (RPP), and indices for LV wall tension (IVST, LVEDD and NT-BNP), in Black-Africans with HF.

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ST-segment depression in hypertensive patients is linked to elevations in blood pressure, pulse pressure and double product by 24-h Cardiotens monitoring

Cited by 36 publications

References 32 publications

Age-Related Reduction of Systemic Arterial Compliance Induces Excessive Myocardial Oxygen Consumption during Sub-Maximal Exercise

Age-Related Reduction of Systemic Arterial Compliance Induces Excessive Myocardial Oxygen Consumption during Sub-Maximal Exercise

Heart rate as a predictor of development of sustained hypertension in subjects screened for stage 1 hypertension: the HARVEST Study

The significance of rate pressure product in heart failure patients

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