“…In addition to usual precautions, such as proper sheath exchange, proper aspiration, and preferably connecting long sheaths to a controlled flush line, maintaining the target ACT for side-selective transseptal puncture using laser technology to facilitate crossing of the septum in difficult situations may be performed. 14 One of the advantages of using laser in such situations is that it not only makes the procedure easy but can also be less thermally damaging to the coronary arteries. 15 , 16 …”