Ensuring the safety of the railway vehicles over bridges shaken by earthquakes is a practical issue in the seismic design of railway bridges. To improve the vehicle’s running safety on railway bridges during earthquakes, the stopper (or bump-stop) between the bogie and the car-body of the vehicle was modified as a fuse-type element, i.e., it was designed to break under large impact due to earthquake occurrence. The efficacy of the fuse stopper was illustrated by a full-scale vehicle-track shake table test. The fuse stopper element was introduced to the vehicle-bridge interaction model, whose accuracy was also demonstrated by comparison with the test results. The fuse stopper was designed to remain intact under service level earthquakes (SLE) to avoid frequent replacement or repair, while it should fuse to improve vehicle safety on a group of bridges under design basis earthquakes (DBE). The bridge group includes 24 simply-supported bridges with pier heights ranging from 6m to 60m, covering the most simply-supported bridges in the China railway network. A total of 10 ground motion records were used in the analysis to account for the uncertainty of ground motions. Through vehicle-bridge incremental dynamic analysis (IDA) simulation, the optimal fusion strength of 188 kN and the extended gap of 0.04 m were proposed for the fuse stopper at DBE intensity, in which the bridge group can achieve derailment-free. The design procedure of the fuse stopper may provide a cost-effective way to improve the vehicle’s running safety on a group of bridges during earthquakes.