Stability, Antioxidant Activity and Intestinal Permeation of Oleuropein Inclusion Complexes with Beta-Cyclodextrin and Hydroxypropyl-Beta-Cyclodextrin

Liu, Hui; Luo, Jinhua; Yang, Ping; Yang, Xiulan; Yan, Jun; Qian, Yu

doi:10.3390/molecules27165077

Cited by 5 publications

(2 citation statements)

References 45 publications

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“…It can be seen from Figure 3 b that MLX had a single sharp melting endothermic peak at about 271 °C, corresponding to the melting temperature of MLX [ 25 ]. Compared to MLX, HP-β-CD ( Figure 3 a) had an endothermic peak of around 75 °C and a complex endothermic peak from 300 to 370 °C, which corresponded with water dissociation from the compound and the melting point and decomposition of HP-β-CD, respectively [ 26 ]. In the physical mixture of MLX and HP-β-CD ( Figure 3 c), there were both endothermic peaks of MLX and HP-β-CD, indicating that there was almost no interaction between the two components.…”

Section: Resultsmentioning

confidence: 99%

Preparation and In Vitro and In Vivo Evaluation of Rectal In Situ Gel of Meloxicam Hydroxypropyl-β-cyclodextrin Inclusion Complex

et al. 2023

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Meloxicam (MLX) is one of the most effective NSAIDs, but its poor water solubility and low bioavailability limit its clinical application. In this study, we designed a thermosensitive in situ gel of the hydroxypropyl-β-cyclodextrin inclusion complex (MLX/HP-β-CD-ISG) for rectal delivery to improve bioavailability. The best method for preparing MLX/HP-β-CD was the saturated aqueous solution method. The optimal inclusion prescription was optimized using an orthogonal test, and the inclusion complex was evaluated via PXRD, SEM, FTIR and DSC. Then, MLX/HP-β-CD-ISG was characterized regarding the gel properties, release in vitro, and pharmacokinetics in vivo. The inclusion rate of the inclusion complex obtained via the optimal preparation process was 90.32 ± 3.81%. The above four detection methods show that MLX is completely embedded in the HP-β-CD cavity. The developed MLX/HP-β-CD-ISG formulation has a suitable gelation temperature of 33.40 ± 0.17 °C, a gelation time of 57.33 ± 5.13 s, pH of 7.12 ± 0.05, good gelling ability and meets the requirements of rectal preparations. More importantly, MLX/HP-β-CD-ISG significantly improved the absorption and bioavailability of MLX in rats, prolonging the rectal residence time without causing rectal irritation. This study suggests that the MLX/HP-β-CD-ISG can have a wide application prospect with superior therapeutic benefits.

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Section: Resultsmentioning

confidence: 99%

Preparation and In Vitro and In Vivo Evaluation of Rectal In Situ Gel of Meloxicam Hydroxypropyl-β-cyclodextrin Inclusion Complex

et al. 2023

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“…At the same time, the characteristic endothermic peak of MA at 159 °C disappears. A small endothermic peak appears at 226 °C, which is the melting temperature of HP-β-CD/MA microcapsules, indicating that MA is successfully embedded in the cavity of HP-β-CD molecules [ 37 ].…”

Section: Resultsmentioning

confidence: 99%

Preparation and Embedding Characterization of Hydroxypropyl-β-cyclodextrin/Menthyl Acetate Microcapsules with Enhanced Stability

et al. 2023

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Objective: Hydroxypropyl-β-cyclodextrin (HP-β-CD)/menthyl acetate (MA) microcapsules were developed to overcome the volatile and unstable defects of MA and improve the ease of use and storage. Methods: MA microcapsules were prepared via spray drying using HP-β-CD as the wall material. The embedding rate of MA microcapsules was determined through gas chromatography. The embedding characteristics were studied using phase solubility and nuclear magnetic resonance (NMR). The stability was characterized via differential scanning calorimetry (DSC) and the release and retention rates of MA microcapsules at different temperatures. Results: The embedding rate of HP-β-CD /MA microcapsules was 96.3%. The Gibbs free energy change, enthalpy change and entropy change of the embedding reaction between HP-β-CD and MA were all less than zero, indicating that the embedding process was a spontaneous exothermic reaction. NMR spectra showed that MA entered the cavity of HP-β-CD through the large opening end and interacted with the inner wall of the small opening end. DSC and the release and retention rates of MA microcapsules at different temperatures showed that the stability of MA was significantly enhanced after being embedded in HP-β-CD. Conclusion: The HP-β-CD/MA microcapsules are able to significantly improve the stability of MA and reduce the volatilization of MA.

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Evaluation of molecular inclusion of azole antifungals by β-cyclodextrin using computational molecular approach

Shikha,

Kar

2024

Discov. Chem.

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Stability, Antioxidant Activity and Intestinal Permeation of Oleuropein Inclusion Complexes with Beta-Cyclodextrin and Hydroxypropyl-Beta-Cyclodextrin

Cited by 5 publications

References 45 publications

Preparation and In Vitro and In Vivo Evaluation of Rectal In Situ Gel of Meloxicam Hydroxypropyl-β-cyclodextrin Inclusion Complex

Preparation and In Vitro and In Vivo Evaluation of Rectal In Situ Gel of Meloxicam Hydroxypropyl-β-cyclodextrin Inclusion Complex

Preparation and Embedding Characterization of Hydroxypropyl-β-cyclodextrin/Menthyl Acetate Microcapsules with Enhanced Stability

Evaluation of molecular inclusion of azole antifungals by β-cyclodextrin using computational molecular approach

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