Stability determination for cyclized 2,4-dinitrophenyl hydrazone derivative of glucose

To assess electronic absorption spectra, molecular docking, and antibacterial activity, 12 new hydrazone compounds that have different substituents and in different positions were synthesized and characterized. HOMO–LUMO energies and theoretical electronic spectra of synthesized compounds were computed via Gaussian 09 software. Global reactivity descriptors were computed from HOMO–LUMO energies. In addition, 1JXA protein was used for molecular docking studies structure. Staphylococcus aureus ATCC 29213 and Enterococcus faecalis ATCC 29212 (as negative bacteria), Escherichia coli ATCC 25922, and Pseudomonas aeruginosa ATCC 27853 (as gram positive) was selected. Compound 3 was observed to be the most effective against propagations of E. Coli. Similarly, compounds 7 and 9 were found to be the most effective against the reproduction of P. aeroginosa. The most powerful compound against the growth of E. faecalis was ascertained to be compound 7.

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“…Antibacterial activities of the compounds were tested against Gram-positive bacteria Hz, 1H, azomethine). 13…”

Section: Antibacterial Activitymentioning

confidence: 99%

“…These compounds have both biologicals activity and light emission diode (LED) [1][2][3][4], and chemosensor properties [5][6][7][8][9][10]. It is quite popular in theoretical and X-ray studies of this class of compound [11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization, investigation of biological activity, docking studies, and spectroscopic properties of hydrazone compounds containing different substituents

Yilmaz

Çukurovalı

2019

Can. J. Phys.

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Development of a Simple and Sensitive Pre-column Derivatization HPLC Method for the Quantitative Analysis of Miglitol Intermediates

Xiong

Dong

et al. 2021

Chromatographia

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Carbohydrate Analysis in Fermentation Samples by Reversed-Phase Liquid Chromatography with Mass Spectrometry Detection Using Precolumn Derivatization with Dibenzylamine

Tang

Wan

et al. 2022

Chromatographia

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Stability determination for cyclized 2,4-dinitrophenyl hydrazone derivative of glucose

Cited by 6 publications

References 30 publications

Synthesis, characterization, investigation of biological activity, docking studies, and spectroscopic properties of hydrazone compounds containing different substituents

Synthesis, characterization, investigation of biological activity, docking studies, and spectroscopic properties of hydrazone compounds containing different substituents

Development of a Simple and Sensitive Pre-column Derivatization HPLC Method for the Quantitative Analysis of Miglitol Intermediates

Carbohydrate Analysis in Fermentation Samples by Reversed-Phase Liquid Chromatography with Mass Spectrometry Detection Using Precolumn Derivatization with Dibenzylamine

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