Stability of MCT/LCT‐Based Total Nutrient Admixtures for Neonatal Use Over 30 Hours at Room Temperature

Abstract

For neonatal TNAs, AA level is the most sensitive determinant of stability, and the PFAT5 parameter is the most sensitive indicator of stability.

Parenteral nutrition in a neonatal intensive care unit: galenic stability of four all-in-one admixtures

“…It was ranged between 5.4 and 5.8 for three admixtures of the four. Anyway, this was reported as common in admixtures for preterm infants and this contributes to avoid calcium–phosphate precipitation since it is below the area of insoluble [CaHPO 4 ] formation 21. Our results correlate with some studies in the literature which reported that small volumes of AIO PNAs with low pH, high calcium concentration and an amino acids concentration above 2% (which is the case here) are stable.…”

Physical Compatibility of Calcium Chloride and Sodium Glycerophosphate in Pediatric Parenteral Nutrition Solutions

“…This approach accounts only for the pH effect of the lipids, leaving other effects untested. In addition, although a simulated test of 1.5% AA plus lipids was performed, previous studies have shown lipid instability in such 3‐in‐1 admixtures containing <4% AA 18 . Our institution routinely compounds 2‐in‐1 PN with the lipids added via y‐site administration.…”

Assessment of the Physicochemical Stability of All‐in‐One Parenteral Emulsions for Neonates According to USP Specifications

“…As the final stability of AIO compounded admixtures is also known to be affected by the composition of commercial lipid emulsions and commercial solutions of amino acids, 15 , 16 each batch of admixtures (batch 1 and batch 2) was prepared in 2 different ways using the most common commercial formulations in Greece. The first using LE1 as the lipid emulsion in combination with AA1 as the amino acid solution (batch S) and the second using LE2 as the lipid emulsion in combination with AA2 as the amino acid solution (batch C).…”