Stability of nitroglycerin ointment

Cossum, Paul A.; Roberts, Michael S.

doi:10.1002/jps.2600700740

Cited by 4 publications

(2 citation statements)

References 12 publications

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“…Volatilization of nitroglycerin, on the other hand, did not seem to be a problem. Unintentional transmission through interpersonal touch, on the other hand, was a challenge, as illustrated by a spousal headache following intercourse with a spouse who had rubbed a nitroglycerin patch on his penis to relieve erectile dysfunction [72,73].…”

Section: From the Ointment To The Transdermal Patches: Nitroglycerin ...mentioning

confidence: 99%

Transdermal Patches for the Treatment of Angina Pectoris: An Effective Drug Delivery System-a Review

et al. 2022

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Topical delivery methods have been used since the dawn of time, employed to cure a wide range of ailments and for aesthetic purposes. Transdermal drug delivery has evolved throughout time, with the development of passive and active technologies that have resulted in enhanced distribution, accuracy in drug dosage, and better fulfilment of the requirements of the individual. The search for more powerful pharmaceuticals that can be delivered to the skin through appropriate transdermal technologies will continue to be a focus in the development of drugs for transdermal patches and other forms of delivery. Topical and transdermal distribution has been around for a while, but this review will focus on transdermal patches and how they've evolved. The articles have been searched on different search engines such as Scopus database, Science direct, PubMed, Google scholar, and Bentham science using multiple keywords. An adhesive transdermal patch is applied to the skin and contains medicine that is absorbed into the bloodstream through the skin. It aids in the recovery of an afflicted part of the body. When compared to oral, topical, i. v., and i. m. administration systems, transdermal drug delivery allows a controlled release of the medicine into patients, often by either a porous membrane or by body heat melting small layers of medication embedded in the adhesive. The fundamental drawback of transdermal delivery methods is that the skin is a highly efficient barrier, therefore, only tiny molecules can enter the skin and be administered in this manner.

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Section: From the Ointment To The Transdermal Patches: Nitroglycerin ...mentioning

confidence: 99%

Transdermal Patches for the Treatment of Angina Pectoris: An Effective Drug Delivery System-a Review

et al. 2022

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“…every 8 h for Nitro‐Bid, to achieve the intended therapeutic effect, which is likely to lead to greater patient non‐compliance than once daily dosing possible with patches. However, nitroglycerin volatilization appeared not to be an issue (Cossum and Roberts, ). In contrast, unintentional transfer through interpersonal contact was a problem, as evidenced by the report of spousal headache after intercourse with a partner who had rubbed a nitroglycerin patch on his penis to treat erectile dysfunction (Talley and Crawley, ).…”

Section: Historymentioning

confidence: 99%

Transdermal patches: history, development and pharmacology

Pastore

Kalia

Horstmann³

et al. 2015

British J Pharmacology

435

279

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Transdermal patches are now widely used as cosmetic, topical and transdermal delivery systems. These patches represent a key outcome from the growth in skin science, technology and expertise developed through trial and error, clinical observation and evidence-based studies that date back to the first existing human records. This review begins with the earliest topical therapies and traces topical delivery to the present-day transdermal patches, describing along the way the initial trials, devices and drug delivery systems that underpin current transdermal patches and their actives. This is followed by consideration of the evolution in the various patch designs and their limitations as well as requirements for actives to be used for transdermal delivery. The properties of and issues associated with the use of currently marketed products, such as variability, safety and regulatory aspects, are then described. The review concludes by examining future prospects for transdermal patches and drug delivery systems, such as the combination of active delivery systems with patches, minimally invasive microneedle patches and cutaneous solutions, including metered-dose systems.

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