Stability of ripple events during task engagement in human hippocampus

Chen, Yvonne; Aponik-Gremillion, Lyndsey; Bartoli, Eleonora; Yoshor, Daniel; Sheth, Sameer A.; Foster, Brett L.

doi:10.1016/j.celrep.2021.109304

Cited by 22 publications

(15 citation statements)

References 37 publications

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“…5 ) 37 , 109 , 110 . Of note, ripple rates have been reported to be higher with recall of remote autobiographical or imagined future events, compared to semantic information 37 , 68 . Conversely, SPW-R rate is decreased during arithmetic calculations 37 , similar to SPW-R suppression in rodents during high attention states 7 , 20 .…”

Section: Problem 3 Arousal Attention and Behavioral Statesmentioning

confidence: 99%

“…As SPW-R are only recorded in the immediate vicinity of the CA1 pyramidal layer in rodents and monkeys, macroelectrode detection of ripples in human hippocampus is surprising. Several papers have reported electrode placement within hippocampus, or specified subfield-level locations (e.g., dentate, CA1-CA3) 36 , 37 , 39 , 68 . However, localization by layer is rare 9 , 12 , 69 – 72 and the recording sites often include mixed hippocampal, subicular and entorhinal regions.…”

Section: Problem 2: Recording and Detection Of Spw-rsmentioning

confidence: 99%

“…The large difference within individuals between SPW-R rates during NREM and REM sleep can provide a useful positive control. Waveform, frequency, duration, and amplitude features of NREM SPW-Rs can be compared with supposed ripple events detected during cognitive tasks 68 , 111 . Assigning likelihood scores to detected SPW-R events from the entire dataset, then performing analysis on a subset of highly likely SPW-Rs, would increase confidence in the findings.…”

Section: Problem 3 Arousal Attention and Behavioral Statesmentioning

confidence: 99%

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A consensus statement on detection of hippocampal sharp wave ripples and differentiation from other fast oscillations

et al. 2022

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Decades of rodent research have established the role of hippocampal sharp wave ripples (SPW-Rs) in consolidating and guiding experience. More recently, intracranial recordings in humans have suggested their role in episodic and semantic memory. Yet, common standards for recording, detection, and reporting do not exist. Here, we outline the methodological challenges involved in detecting ripple events and offer practical recommendations to improve separation from other high-frequency oscillations. We argue that shared experimental, detection, and reporting standards will provide a solid foundation for future translational discovery.

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Section: Problem 3 Arousal Attention and Behavioral Statesmentioning

confidence: 99%

Section: Problem 2: Recording and Detection Of Spw-rsmentioning

confidence: 99%

Section: Problem 3 Arousal Attention and Behavioral Statesmentioning

confidence: 99%

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A consensus statement on detection of hippocampal sharp wave ripples and differentiation from other fast oscillations

et al. 2022

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“…SW-R hallmark hippocampal dynamics during sleep. The majority of studies focused on the rodent hippocampus during sleep, but SW-R have also been described in hippocampal and adjacent MTL structures in humans using intracranial recordings (Axmacher et al, 2008;Bragin et al, 1999;Chen et al, 2021;Helfrich et al, 2019;Norman et al, 2019;Staresina et al, 2015;Vaz et al, 2019).…”

Section: Uniform Sw-r Morphology Across Regions and Speciesmentioning

confidence: 99%

An evolutionary conserved division-of-labor between hippocampal and neocortical sharp-wave ripples organizes information transfer during sleep

Schalkwijk

Weber

Hahn

et al. 2022

Preprint

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The hippocampal sharp-wave ripple (SW-R) is the key substrate of the hippocampal-neocortical dialogue underlying memory formation. Recently, it became evident that SW-R are not unique to archicortex, but constitute a wide-spread neocortical phenomenon. To date, little is known about morphological and functional similarities between archi- and neocortical SW-R. Leveraging intracranial recordings from the human hippocampus and prefrontal cortex during sleep, our results reveal region-specific functional specializations, albeit a near-uniform morphology. While hippocampal SW-R trigger directional hippocampal-to-neocortical information flow, neocortical SW-R reduce information flow to minimize interference. At the population level, hippocampal SW-R confined population dynamics to a low-dimensional subspace, while neocortical SW-R diversified the population response; functionally uncoupling the hippocampal-neocortical network. Critically, our replication in rodents demonstrated the same division-of-labor between archi-and neocortical SW-R. These results uncover an evolutionary preserved mechanism where coordinated interplay between hippocampal and neocortical SW-R temporally segregates hippocampal information transfer from neocortical processing.

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“…Hippocampal SWR occurrence of monkeys is increased when the subject’s gaze is focused near a target object during search or when patients observe familiar pictures of scenes or faces ( 5 , 26 , 28 ). Here, ripple rates also increased during free recall along with a high-frequency band activation around the time of ripple in the visual cortex, suggesting a role of SWRs in activating the visual cortex during episodic and semantic memory retrieval ( 5 , 19 , 26 , 28 – 31 ). Memory and attention are intertwined, and working memory and attention affect neural activity in striate and extrastriate cortex similarly ( 32 , 33 ).…”

mentioning

confidence: 79%

Ripples in macaque V1 and V4 are modulated by top-down visual attention

Doostmohammadi

Gieselmann

Kempen

et al. 2023

Proc. Natl. Acad. Sci. U.S.A.

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Sharp-wave ripples (SWRs) are highly synchronous neuronal activity events. They have been predominantly observed in the hippocampus during offline states such as pause in exploration, slow-wave sleep, and quiescent wakefulness. SWRs have been linked to memory consolidation, spatial navigation, and spatial decision-making. Recently, SWRs have been reported during visual search, a form of remote spatial exploration, in macaque hippocampus. However, the association between SWRs and multiple forms of awake conscious and goal-directed behavior is unknown. We report that ripple activity occurs in macaque visual areas V1 and V4 during focused spatial attention. The occurrence of ripples is modulated by stimulus characteristics, increased by attention toward the receptive field, and by the size of the attentional focus. During attention cued to the receptive field, the monkey’s reaction time in detecting behaviorally relevant events was reduced by ripples. These results show that ripple activity is not limited to hippocampal activity during offline states, rather they occur in the neocortex during active attentive states and vigilance behaviors.

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Stability of ripple events during task engagement in human hippocampus

Cited by 22 publications

References 37 publications

A consensus statement on detection of hippocampal sharp wave ripples and differentiation from other fast oscillations

A consensus statement on detection of hippocampal sharp wave ripples and differentiation from other fast oscillations

An evolutionary conserved division-of-labor between hippocampal and neocortical sharp-wave ripples organizes information transfer during sleep

Ripples in macaque V1 and V4 are modulated by top-down visual attention

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