Stabilization and sustained-release effect of Misoprostol with Methacrylate copolymer

Chen, David; Tsay, Rong-Jer; Lin, Hue-In; Chen, Huilan; Chao, Shou-Chung; Ku, Hao

doi:10.1016/s0378-5173(00)00451-8

Cited by 16 publications

(7 citation statements)

References 12 publications

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“…Figure 4 illustrates the applications of water-insoluble carriers for SDs. For example, Eudragit ® RS 100 and RL 100 have been utilized in sustained-release SDs because they are insoluble at physiological pH values but can swell and become permeable to water [95][96][97]. By formulating misoprostol in SD matrices with these polymers, drug release could be slowed, and drug stability can be protected from degradation by water [96].…”

Section: Nano-sized Sds From Enteric Coating Polymersmentioning

confidence: 99%

Insoluble Polymers in Solid Dispersions for Improving Bioavailability of Poorly Water-Soluble Drugs

Tran

2020

Polymers

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In recent decades, solid dispersions have been demonstrated as an effective approach for improving the bioavailability of poorly water-soluble drugs, as have solid dispersion techniques that include the application of nanotechnology. Many studies have reported on the ability to change drug crystallinity and molecular interactions to enhance the dissolution rate of solid dispersions using hydrophilic carriers. However, numerous studies have indicated that insoluble carriers are also promising excipients in solid dispersions. In this report, an overview of solid dispersion strategies involving insoluble carriers has been provided. In addition to the role of solubility and dissolution enhancement, the perspectives of the use of these polymers in controlled release solid dispersions have been classified and discussed. Moreover, the compatibility between methods and carriers and between drug and carrier is mentioned. In general, this report on solid dispersions using insoluble carriers could provide a specific approach and/or a selection of these polymers for further formulation development and clinical applications.

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Section: Nano-sized Sds From Enteric Coating Polymersmentioning

confidence: 99%

Insoluble Polymers in Solid Dispersions for Improving Bioavailability of Poorly Water-Soluble Drugs

Tran

2020

Polymers

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show abstract

“…As many reports [18,19] illustrated that misoprostol is chemically unstable under ambient conditions, it was necessary to check the stability of misoprostol under operational circumstances. A 5 mg/mL solution of misoprostol was used.…”

Section: Stability Of the Sample Solutionsmentioning

confidence: 99%

Development and validation of LC methods for the separation of misoprostol related substances and diastereoisomers

Kahsay

Song

Eerdekens

et al. 2015

Journal of Pharmaceutical and Biomedical Analysis

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“…A tablet weight (0.2 g) of placebo powder was prepared from the mixture of 2 mg hydrogenated castor oil, 10 mg sodium starch glycolate, 168 mg microcrystalline cellulose and 20 mg hydroxypropyl methylcellulose [9,12,13]. Blank water extract was prepared by mixing, homogenizing and vortexing 2 ml of water with placebo powder for 5 min.…”

Section: Placebo Powder and Blank Water Extract Of Placebo Powdermentioning

confidence: 99%

“…Some studies have used a low UV range for misoprostol detection [8,9], but the determinations were seriously influenced by solvent effect. Most studies have attempted to use mass spectrometry for detection of these prostaglandins.…”

Section: Introductionmentioning

confidence: 99%

Method to determine stability and recovery of carboprost and misoprostol in infusion preparations

Chu

Wang²,

Pang

et al. 2007

Journal of Chromatography B

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Stabilization and sustained-release effect of Misoprostol with Methacrylate copolymer

Cited by 16 publications

References 12 publications

Insoluble Polymers in Solid Dispersions for Improving Bioavailability of Poorly Water-Soluble Drugs

Insoluble Polymers in Solid Dispersions for Improving Bioavailability of Poorly Water-Soluble Drugs

Development and validation of LC methods for the separation of misoprostol related substances and diastereoisomers

Method to determine stability and recovery of carboprost and misoprostol in infusion preparations

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