Stabilizing gelatin-based bioinks under physiological conditions by incorporation of ethylene-glycol-conjugated Fmoc-FF peptides

Netti, Francesca; Aviv, Moran; Dan, Yoav; Rudnick-Glick, Safra; Halperin‐Sternfeld, Michal; Adler‐Abramovich, Lihi

doi:10.1039/d1nr08206j

Cited by 15 publications

(7 citation statements)

References 51 publications

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“…Gelatin derived through partial hydrolysis of collagen has advantages such as good biocompatibility, non-immunogenicity, cell-affinity, and complete biodegradability in vivo [ 73 ]. Gelatin is widely used for tissue engineering applications as it possesses a similar composition to collagen.…”

Section: Biomaterials and Bioinksmentioning

confidence: 99%

Biomaterials / bioinks and extrusion bioprinting

Chen,

Fazel Anvari-Yazdi,

Duan

et al. 2023

Bioactive Materials

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Section: Biomaterials and Bioinksmentioning

confidence: 99%

Biomaterials / bioinks and extrusion bioprinting

Chen,

Fazel Anvari-Yazdi,

Duan

et al. 2023

Bioactive Materials

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“…12 Other natural polymers were also used to fabricate supramolecular-polymeric composite hydrogels. [13][14][15][16] Synthetic polymers [17][18][19] were also used as polymeric networks to fabricate composite hydrogels. All these supramolecular-polymeric DN hydrogels exhibited improved mechanical properties.…”

Section: Introductionmentioning

confidence: 99%

Mimic enzymatic preparation of conductive supramolecular-polymeric hydrogels with antibacterial and antioxidant properties for accelerating wound healing

et al. 2023

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“…Since its identification in 2006 [ 14 , 15 ] as a suitable building block for the preparation of hydrogels, Fmoc-FF has been deeply studied for many biomedical applications [ 21 , 22 , 23 , 24 ]. The addition of other components (like natural or synthetic polymers [ 25 ], peptides [ 26 , 27 ], polysaccharides [ 28 ], or dyes [ 29 ]) to Fmoc-FF has been found to improve and tune the physiochemical features of the final material.…”

Section: Introductionmentioning

confidence: 99%

Incorporation of PEG Diacrylates (PEGDA) Generates Hybrid Fmoc-FF Hydrogel Matrices

Rosa

Gallo²,

Sibillano

et al. 2022

Gels

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Generated by a hierarchical and multiscale self-assembling phenomenon, peptide-based hydrogels (HGs) are soft materials useful for a variety of applications. Short and ultra-short peptides are intriguing building blocks for hydrogel fabrication. These matrices can also be obtained by mixing low-molecular-weight peptides with other chemical entities (e.g., polymers, other peptides). The combination of two or more constituents opens the door to the development of hybrid systems with tunable mechanical properties and unexpected biofunctionalities or morphologies. For this scope, the formulation, the multiscale analysis, and the supramolecular characterization of novel hybrid peptide-polymer hydrogels are herein described. The proposed matrices contain the Fmoc-FF (Nα-fluorenylmethyloxycarbonyl diphenylalanine) hydrogelator at a concentration of 0.5 wt% (5.0 mg/mL) and a diacrylate α-/ω-substituted polyethylene-glycol derivative (PEGDA). Two PEGDA derivatives, PEGDA 1 and PEGDA2 (mean molecular weights of 575 and 250 Da, respectively), are mixed with Fmoc-FF at different ratios (Fmoc-FF/PEGDA at 1/1, 1/2, 1/5, 1/10 mol/mol). All the multicomponent hybrid peptide-polymer hydrogels are scrutinized with a large panel of analytical techniques (including proton relaxometry, FTIR, WAXS, rheometry, and scanning electronic microscopy). The matrices were found to be able to generate mechanical responses in the 2–8 kPa range, producing a panel of tunable materials with the same chemical composition. The release of a model drug (Naphthol Yellow S) is reported too. The tunable features, the different topologies, and the versatility of the proposed materials open the door to the development of tools for different applicative areas, including diagnostics, liquid biopsies and responsive materials. The incorporation of a diacrylate function also suggests the possible development of interpenetrating networks upon cross-linking reactions. All the collected data allow a mutual comparison between the different matrices, thus confirming the significance of the hybrid peptide/polymer-based methodology as a strategy for the design of innovative materials.

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Stabilizing gelatin-based bioinks under physiological conditions by incorporation of ethylene-glycol-conjugated Fmoc-FF peptides

Abstract: Over the last decade, three-dimensional (3D) printing technologies have attracted the interest of researchers due to the possibility of fabricating tissue- and organ-like structures with similarities to the organ of...

Cited by 15 publications

References 51 publications

Biomaterials / bioinks and extrusion bioprinting

Biomaterials / bioinks and extrusion bioprinting

Mimic enzymatic preparation of conductive supramolecular-polymeric hydrogels with antibacterial and antioxidant properties for accelerating wound healing

Incorporation of PEG Diacrylates (PEGDA) Generates Hybrid Fmoc-FF Hydrogel Matrices

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