Stabilizing US-Pakistan Relations: A Way Forward

Abstract

Sensors and Electron Devices Directorate, ARLApproved for public release; distribution unlimited. ii REPORT DOCUMENTATION PAGEForm Public reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing the collection information. Send comments regarding this burden estimate or any other aspect of this collection of information, including suggestions for reducing the burden, to Department of Defense, Washington Headquarters Services, Directorate for Information Operations and Reports (0704-0188), 1215 Jefferson Davis Highway, Suite 1204, Arlington, VA 22202-4302. Respondents should be aware that notwithstanding any other provision of law, no person shall be subject to any penalty for failing to comply with a collection of information if it does not display a currently valid OMB control number. PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS. REPORT DATE (DD-MM-YYYY) April 20082. REPORT TYPE ARL-TR-4420 SPONSOR/MONITOR'S ACRONYM(S) 9. SPONSORING/MONITORING AGENCY NAME(S) AND ADDRESS(ES) SPONSOR/MONITOR'S REPORT NUMBER(S) DISTRIBUTION/AVAILABILITY STATEMENTApproved for public release; distribution unlimited. SUPPLEMENTARY NOTES ABSTRACTThis technical report presents numerical simulations of the ultra-wideband (UWB) radar return from a simple room with a human inside, with application to sensing through the wall (STTW) radar scenarios. We use the Finite Difference Time Domain (FDTD) and Xpatch modeling techniques to compute the range profiles of the room at specific incidence and observation angles. Our goal is to analyze the electromagnetic phenomenology in operating an UWB radar for STTW applications. At the same time, we are interested in understanding issues specific to these computational techniques as applied to this type of problems, as well as validating Xpatch as an accurate tool for modeling general STTW radar scenarios. SUBJECT TERMSSensing through the wall, radar, computational electromagnetics SECURITY CLASSIFICATION OF:19a. NAME OF RESPONSIBLE PERSON

Synthesis and evaluation of highly selective quinazoline-2,4-dione ligands for sphingosine-1-phosphate receptor 2

“…Chemistry Compound 1 was reported as a potent S1PR2 ligand for treating inflammatory and allergic conditions in animals through targeting S1PR2. 27 Therefore, our efforts had focused on structural optimization of compound 1 to develop new S1PR2 compounds. We expect that our structural modification will lead to the discovery of new S1PR2 ligands with high potency and selectivity, which can be radiosynthesized using conventional C-11 or F-18 radiochemistry methods for further in vivo evaluation in animals.…”

“…Firstly, we modified the carboxylic acid group in the structure of compound 1 using carboxylic acid amides to prepare new compounds 2a-k as shown in Scheme 1. Compound 1 was made according to the literature 27 and served as a key intermediate. Using 1-[bis(dimethylamino)methylene]-1H-1,2,3triazolo[4,5b]pyridinium 3-oxid hexafluorophosphate (HATU) and N,N-diisopropylethylamine (DIPEA) as coupling agents at room temperature (RT), compound 1 reacted with different substituted amines to generate compounds 2a-k.…”