Stable biocompatible cross-linked fluorescent polymeric nanoparticles based on AIE dye and itaconic anhydride

Li, Haiyin; Zhang, Xiqi; Yang, Bin; Wei, Yen

doi:10.1016/j.colsurfb.2014.06.015

Cited by 23 publications

(19 citation statements)

References 39 publications

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“…As shown in Figure a,b, after coated on the surface of SPIO, the acid CO peak of PAA at 1670 cm −1 weakened and a new band at 629 cm −1 represents the Fe─O band vibration of SPIO appeared . As shown in Figure c, the characteristic peaks at 1120, 1570–1220, and 3430 cm −1 were, respectively, attributed to the C─O band in mPEG, the stretching vibration of aromatic rings in TPE, and the stretching vibration of N─H band in PEI, confirming the successful synthesis of PEG‐PEI‐TPE . All characteristic peaks of PAA‐coated SPIO and PEG‐PEI‐TPE could be found in the spectra of PEG‐PEI‐TPE/SPIO [Figure (d)].…”

Section: Resultssupporting

confidence: 54%

Controlled aggregation of amphiphilic aggregation‐induced emission polycation and superparamagnetic iron oxide nanoparticles as fluorescence/magnetic resonance imaging probes

Cai

Liu

et al. 2019

J of Applied Polymer Sci

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Fluorescence/magnetic resonance (MR) dual‐mode imaging, which combines the excellent single‐cell sensitivity of fluorescence imaging and the high spatial resolution of MR imaging, has been applied to different biomedical applications. However, the aggregation‐caused quenching characteristic of most fluorescence molecules often put limits in their applications. Herein, a fluorescence/MR dual‐mode imaging probe [polyethylene glycol‐polyethylenimine‐tetraphenylethene (PEG‐PEI‐TPE)/superparamagnetic iron oxide (SPIO)] with aggregation‐induced emission characteristic is prepared by coupling poly(acrylic acid)‐coated SPIO with PEG‐PEI‐TPE. The fluorescence intensity and lifetime of PEG‐PEI‐TPE/SPIO is higher than PEG‐PEI‐TPE especially at lower polymer concentrations (≤0.2 mg mL−1). Moreover, the fluorescence intensity of PEG‐PEI‐TPE/SPIO gradually increased along with the decline of the pH from 9.0 to 4.0, which is beneficial for studying intracellular organelles. The T2 relaxivity of PEG‐PEI‐TPE/SPIO is 212.3 Fe mM−1 s−1 under a 3.0 T MR scanner. Cell labeling experiment shows that PEG‐PEI‐TPE/SPIO can effectively label RAW 264.7 and Hela cells, and labeled cells are visible under both fluorescence and clinical MR examinations. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020, 137, 48760.

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Section: Resultssupporting

confidence: 54%

Controlled aggregation of amphiphilic aggregation‐induced emission polycation and superparamagnetic iron oxide nanoparticles as fluorescence/magnetic resonance imaging probes

Cai

Liu

et al. 2019

J of Applied Polymer Sci

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“…[52] Therefore, the CMC of F127-TMAC-PhNH2 FONs was determined based on our previous studies. [53] In the work, we demonstrated that the CMC of F127-TMAC-PhNH2 FONs is as low as 0.018 mg mL -1 . The low CMC of F127-TMAC-PhNH2 FONs is very important for their biomedical applications as drug delivery carriers as well as luminescent probes.…”

Section: Characterization Of F127-tmac-phnh2 Fonsmentioning

confidence: 82%

Facile synthesis of AIE-active amphiphilic polymers: Self-assembly and biological imaging applications

Long

Liu

Wang

et al. 2016

Materials Science and Engineering: C

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In this work, we reported a rather facile method for fabrication of ultrabright, well dispersible and biocompatible fluorescent organic nanoparticles (FONs) with aggregation-induced emission (AIE) properties through combination of esterification and ring-opening reaction. The hydroxyl groups of Pluronic F127 was first reacted with the chloride of trimellitic anhydride chloride (TMAC), and its anhydride groups were further reacted with the amino groups of amino-terminated AIE dye (PhNH2) through ring-opening reaction. The optical properties, biocompatibility as well as cell uptake behavior of these obtained AIE-active nanoparticles (F127-TMAC-PhNH2 FONs) were examined by a series of characterization techniques and assays. We demonstrated that uniform organic nanoparticles with high water dispersibility, strong luminescence and desirable biocompatibility can be facilely obtained, which are promising for biological imaging applications. More importantly, a number of carboxyl groups were introduced into these AIE-active nanoparticles, which can be further utilized for further conjugation reaction and carrying anticancer drugs such as cisplatin. Therefore, the strategy of described in this work should be a simple and useful route for fabrication of multifunctional AIE-active luminescent nanotheranostic systems.

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“…Its structure was characterized and confirmed by standard spectroscopic methods. 11,51 For preparation of PhE2-ITA-Glu, PhE2 was first employed to react with ITA via free radical polymerization to get a cross-linked hydrophobic copolymer. Then PhE2-ITA copolymer reacted with Glu through ring-opening reaction at room temperature to obtain the amphiphilic glycopolymer.…”

Section: Preparation and Characterization Of Phe2-ita-glu Copolymermentioning

confidence: 99%

Fabrication of stable and biocompatible red fluorescent glycopolymer nanoparticles for cellular imaging

Wang

Zhang

et al. 2015

Tetrahedron

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Stable biocompatible cross-linked fluorescent polymeric nanoparticles based on AIE dye and itaconic anhydride

Cited by 23 publications

References 39 publications

Controlled aggregation of amphiphilic aggregation‐induced emission polycation and superparamagnetic iron oxide nanoparticles as fluorescence/magnetic resonance imaging probes

Controlled aggregation of amphiphilic aggregation‐induced emission polycation and superparamagnetic iron oxide nanoparticles as fluorescence/magnetic resonance imaging probes

Facile synthesis of AIE-active amphiphilic polymers: Self-assembly and biological imaging applications

Fabrication of stable and biocompatible red fluorescent glycopolymer nanoparticles for cellular imaging

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