Stable Chloramphenicol Solution for Ocular Infections

Widespread ocular use of topical chloramphenicol: is there justifiable concern regarding idiosyncratic aplastic anaemia?

“…'2 14 Systemic chloramphenicol, in addition to lesser adverse reactions such as gastrointestinal disturbance and rash, is also associated with the much more serious and potentially lethal effects of bone marrow toxicity. This can take the form of dose related marrow suppression involving one or more cell lines which may or may not be reversible or the much more rare idiosyncratic aplastic anaemia.…”

Liposomal Phospholipid Preparations of Chloramphenicol for Ophthalmic Applications

“…CAP ( Fig. 1) is a relatively inexpensive, broad-spectrum antibacterial agent, with a reported efficacy of 91-93% in ocular infections, 3,4 and is active against up to 94% of ocular pathogens. 5,6 Generally, topical CAP is very well tolerated, and adverse effects such as hypersensitivity, burning, and stinging sensations are uncommon.…”