Stable expression and multi-site location of Odf2 in mouse oocytes, sperm and early embryos

Xu, Xiangning; Jiang, Xiuying; Song, Ke; Zhang, Jiaqi; Tian, Ying; Chen, Ye; Weng, Jing Ru; Liang, Yuanzheng; Ma, Wei

doi:10.1016/j.aanat.2023.152126

Cited by 1 publication

(1 citation statement)

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“…To our knowledge, literature describing molecular components in oocyte centrosome elimination is limited across most vertebrate species. Recently in mice, the centriole appendage protein outer dense fiber of sperm tails 2 (Odf2), also known as cenexin in humans, was found to localize to microtubule-organizing centers (MTOCs), chromosome centromeres and cytoplasmic vesicles during oocyte meiotic progression, despite the absence of intact centrioles ( Xu et al, 2023 ). This suggests that centriole structural proteins might not be eliminated and are instead reorganized to regulate spindle assembly and positioning after the elimination of centrioles.…”

Section: Centrosomes During Gametogenesismentioning

confidence: 99%

The centrosome – diverse functions in fertilization and development across species

Aljiboury,

Hehnly

2023

Journal of Cell Science

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The centrosome is a non-membrane-bound organelle that is conserved across most animal cells and serves various functions throughout the cell cycle. In dividing cells, the centrosome is known as the spindle pole and nucleates a robust microtubule spindle to separate genetic material equally into two daughter cells. In non-dividing cells, the mother centriole, a substructure of the centrosome, matures into a basal body and nucleates cilia, which acts as a signal-transducing antenna. The functions of centrosomes and their substructures are important for embryonic development and have been studied extensively using in vitro mammalian cell culture or in vivo using invertebrate models. However, there are considerable differences in the composition and functions of centrosomes during different aspects of vertebrate development, and these are less studied. In this Review, we discuss the roles played by centrosomes, highlighting conserved and divergent features across species, particularly during fertilization and embryonic development.

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Section: Centrosomes During Gametogenesismentioning

confidence: 99%