Stable gadolinium based nanoscale lyophilized injection for enhanced MR angiography with efficient renal clearance

Liu, Kun; Dong, Liang; Xu, Yongfen; Xu, Yan; Li, Fēi; Lu, Yang; Tao, Wei; Peng, Huang-Yong; Wu, Yadong; Su, Yang; Ling, Daishun; He, Tao; Qian, Haisheng; Yu, Shu‐Hong

doi:10.1016/j.biomaterials.2017.12.023

Cited by 37 publications

(36 citation statements)

References 58 publications

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“…The peak at 1718 cm −1 was assigned to the carbonyl group (C = O) [ 30 ]. The appearance of two peaks at 3440 and 1631 cm –1 were ascribed to the -OH bending vibration, which was consistent with previously reported PAA-coated iron oxide nanoparticles [ 30 , 37 , 38 ]. The X-ray diffraction (XRD) pattern of IONPs was illustrated in Fig.…”

Section: Resultssupporting

confidence: 92%

Effects of iron oxide nanoparticles as T2-MRI contrast agents on reproductive system in male mice

et al. 2022

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Iron oxide nanoparticles (IONPs)-based contrast agents are widely used for T2-weighted magnetic resonance imaging (MRI) in clinical diagnosis, highlighting the necessity and importance to evaluate their potential systematic toxicities. Although a few previous studies have documented the toxicity concerns of IONPs to major organs, limited data are available on the potential reproductive toxicity caused by IONPs, especially when administrated via intravenous injection to mimic clinical use of MRI contrast agents. Our study aimed to determine whether exposure to IONPs would affect male reproductive system and cause other related health concerns in ICR mice. The mice were intravenously injected with different concentrations IONPs once followed by routine toxicity tests of major organs and a series of reproductive function-related analyses at different timepoints. As a result, most of the contrast agents were captured by reticuloendothelial system (RES) organs such as liver and spleen, while IONPs have not presented adverse effects on the normal function of these major organs. In contrast, although IONPs were not able to enter testis through the blood testicular barrier (BTB), and they have not obviously impaired the overall testicular function or altered the serum sex hormones levels, IONPs exposure could damage Sertoli cells in BTB especially at a relative high concentration. Moreover, IONPs administration led to a short-term reduction in the quantity and quality of sperms in a dose-dependent manner, which might be attributed to the increase of oxidative stress and apoptotic activity in epididymis. However, the semen parameters have gradually returned to the normal range within 14 days after the initial injection of IONPs. Collectively, these results demonstrated that IONPs could cause reversible damage to the reproductive system of male mice without affecting the main organs, providing new guidance for the clinical application of IONPs as T2-MRI contrast agents. Graphical Abstract

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Section: Resultssupporting

confidence: 92%

Effects of iron oxide nanoparticles as T2-MRI contrast agents on reproductive system in male mice

et al. 2022

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“…In recent years, MR contrast agents have been widely studied for the early diagnosis of tumors. Generally, there are two types of contrast agents: T1‐weighted contrast agents, like Gd, MnO NPs, and extremely small iron oxide NPs (ESIONPs) (<4 nm), [ 64 ] can reveal a bright signal enhancement and fine anatomic structures; while T2‐weighted contrast agents, such as superparamagnetic iron oxide NPs, generate intrinsic dark signals. [ 65 ]…”

Section: Pdac‐tailored Nanomaterials For Diagnosismentioning

confidence: 99%

Tailor‐Made Nanomaterials for Diagnosis and Therapy of Pancreatic Ductal Adenocarcinoma

Xia

Lee

et al. 2021

Advanced Science

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Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers worldwide due to its aggressiveness and the challenge to early diagnosis and treatment. In recent decades, nanomaterials have received increasing attention for diagnosis and therapy of PDAC. However, these designs are mainly focused on the macroscopic tumor therapeutic effect, while the crucial nano–bio interactions in the heterogeneous microenvironment of PDAC remain poorly understood. As a result, the majority of potent nanomedicines show limited performance in ameliorating PDAC in clinical translation. Therefore, exploiting the unique nature of the PDAC by detecting potential biomarkers together with a deep understanding of nano–bio interactions that occur in the tumor microenvironment is pivotal to the design of PDAC‐tailored effective nanomedicine. This review will introduce tailor‐made nanomaterials‐enabled laboratory tests and advanced noninvasive imaging technologies for early and accurate diagnosis of PDAC. Moreover, the fabrication of a myriad of tailor‐made nanomaterials for various PDAC therapeutic modalities will be reviewed. Furthermore, much preferred theranostic multifunctional nanomaterials for imaging‐guided therapies of PDAC will be elaborated. Lastly, the prospects of these nanomaterials in terms of clinical translation and potential breakthroughs will be briefly discussed.

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“…Therefore, it is essential to functionalize them with a variety of surface ligands, [ 26 ] which not only endow their excellent dispersity and colloidal stability, but also improve their relaxivities. [ 27,28 ]…”

Section: Introductionmentioning

confidence: 99%

Boosting Vascular Imaging‐Performance and Systemic Biosafety of Ultra‐Small NaGdF₄ Nanoparticles via Surface Engineering with Rationally Designed Novel Hydrophilic Block Co‐Polymer

et al. 2022

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Stable gadolinium based nanoscale lyophilized injection for enhanced MR angiography with efficient renal clearance

Cited by 37 publications

References 58 publications

Effects of iron oxide nanoparticles as T2-MRI contrast agents on reproductive system in male mice

Effects of iron oxide nanoparticles as T2-MRI contrast agents on reproductive system in male mice

Tailor‐Made Nanomaterials for Diagnosis and Therapy of Pancreatic Ductal Adenocarcinoma

Boosting Vascular Imaging‐Performance and Systemic Biosafety of Ultra‐Small NaGdF₄ Nanoparticles via Surface Engineering with Rationally Designed Novel Hydrophilic Block Co‐Polymer

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Stable gadolinium based nanoscale lyophilized injection for enhanced MR angiography with efficient renal clearance

Cited by 37 publications

References 58 publications

Effects of iron oxide nanoparticles as T2-MRI contrast agents on reproductive system in male mice

Effects of iron oxide nanoparticles as T2-MRI contrast agents on reproductive system in male mice

Tailor‐Made Nanomaterials for Diagnosis and Therapy of Pancreatic Ductal Adenocarcinoma

Boosting Vascular Imaging‐Performance and Systemic Biosafety of Ultra‐Small NaGdF4 Nanoparticles via Surface Engineering with Rationally Designed Novel Hydrophilic Block Co‐Polymer

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Product

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Boosting Vascular Imaging‐Performance and Systemic Biosafety of Ultra‐Small NaGdF₄ Nanoparticles via Surface Engineering with Rationally Designed Novel Hydrophilic Block Co‐Polymer