Stable Vitiligo Treated by a Combination of Low-Dose Oral Pulse Betamethasone and Autologous, Noncultured Melanocyte-Keratinocyte Cell Transplantation

Mulekar, Sanjeev V.

doi:10.1111/j.1524-4725.2006.32109.x

Cited by 13 publications

(12 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a group of 25 patients who failed to respond, the procedure was repeated with the addition of a low dose oral betamethasone; in 15 of 17 patients with vitiligo vulgaris and in seven of eight with segmental vitiligo good to excellent repigmentation ocurred, suggesting stabilization of vitiligo by corticosteroids (Mulekar, 2006). Recently, a shelf kit, (ReCell Ò ), was developed and in five patients with 10 lesions on a left ⁄ right trial encouraging repigmentation was observed (Mulekar et al, 2008).…”

Section: Non-cultured Melanocyte Suspensionsmentioning

confidence: 99%

Update on skin repigmentation therapies in vitiligo

Falabella

Barona

2009

Pigment Cell Melanoma Res

137

121

View full text Add to dashboard Cite

SummaryTreatment for vitiligo is difficult and prolonged. Nevertheless, at present considerable knowledge accumulated during several decades on the pathogenic mechanisms, revealed important clues for designing new strategies to improve vitiligo depigmentation. With available medical therapies, high repigmentation percentages mostly on facial and neck lesions are achieved, although they are less effective on trunk and limbs and poor on the acral parts of the extremities. Narrow band UVB and psoralens and UVA are the two most important treatments for generalized vitiligo affecting more than 10-20% of the cutaneous surface, and topical corticosteroids, or calcineurin inhibitors are the most valuable treatments for localized vitiligo. Persistence of achieved regimentation is variable and an undefined percentage of patients may have variable recurrence.When vitiligo becomes refractory, surgical methods may improve depigmentation as effectively as with medical therapy; in segmental (unilateral) or long standing, non-segmental (bilateral) stable vitiligo, repigmentation with surgical methods is usually permanent.

show abstract

Section: Non-cultured Melanocyte Suspensionsmentioning

confidence: 99%

Update on skin repigmentation therapies in vitiligo

Falabella

Barona

2009

Pigment Cell Melanoma Res

137

121

View full text Add to dashboard Cite

show abstract

“…All reports in literatures emphasizing in the importance of not using of adrenalin during anesthesia of recipient skin in order to minimize the ischemia of the grafted tissue and to increase the success rate of transplantation [5,6,[8][9][10][11][12][13][14][15][16][17]. While in the present works, we used adrenalin with xylocain in all patients in the recipient area to decrease bleeding during operation.…”

Section: Discussionmentioning

confidence: 98%

“…There are many surgical procedures that have been used to treat vitiligo by autologous melanocytes transplant [4][5][6][7][8][9][10][11][12][13][14][15][16]. In the present study we did two new techniques that had already been most recently published, where direct melanocytes transfer from donor skin into vitiliginous recipient area was carried out [17,18].…”

Section: Discussionmentioning

confidence: 99%

“…In all previous grafting procedures there was no mention of repigmentation of gray hair [5][6][7][8][9][10][11][12][13][14][15][16][19][20][21][22] apart from one study by Agrawal et al in 1995 who showed by split thickness skin graft in eight patients, repigmentation of gray hair that appeared after three months and gradually increased to have full repigmentation of gray hair after six years follow up [10,23].…”

Section: Discussionmentioning

confidence: 99%

“…Melanocytes transplants by different procedures in patient with vitiligo are common procedures like: punch minigraft [5][6][7], suction blister epidermal grafting [8], and split thickness grafting [9,10] and non-cultured melanocytes grafting [11][12][13] and transplantation of cultured autologous melanocytes [14][15][16].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Treatment of Gray Hair in Vitiligo Patients by Direct Melanocytes Transplant Using Needling Micrografting and Dermabrasion Techniques

Sharquie¹,

Noaimi²,

Al-Mudaris³

2013

JCDSA

View full text Add to dashboard Cite

Background: Melanocytes transplant for treatment of vitiligo is a common therapy using different surgical procedures. But there was no interest in repigmentation of grayness of hair in the treated vitiliginous area. Objective: To do melanocytes transplant from donor area into the recipient vitiliginous area with associated gray hair. Patient and Methods: This is a case interventional study was done in Department of Dermatology/Baghdad Teaching Hospital from February 2011-March 2012. Eleven patients were enrolled in this study, six males and five females with vitiligo in association of gray hair. Their ages ranged from 8 -35 years with a mean ± SD of 20.90 ± 7.006. Melanocytes transplant in patients with vitiligo using needling micrografting technique for twelve patches and direct melanocytes transplant from normal donor area into vitiliginous recipient area by dermabrasion technique for eleven patches. Dressing was applied and patients were seen every two weeks for the first month and monthly for one year. Results: Repigmentation of the vitiliginous area was started after two weeks and was obvious at one month that progressed over time. The repigmentation of hair appeared usually after few months and was obvious after four months and the repigmentation of gray hair was quicker in patients with micrografting technique than those with dermabrasion technique. The mean rate of repigmentation was 18.3% at six months and 37.5% at twelve months in micrografting technique while the mean rate of repigmentation was 9.15% at six months and 18.55% at twelve months in dermabrasion technique. Conclusions: Direct transplant of melanocytes from normal donor area into recipient vitiliginous area with associated white hair is an effective procedure to induce repigmentation of gray hair.

show abstract

Surgical Interventions for Patients With Vitiligo

Bae

Lee

et al. 2021

JAMA Dermatol

View full text Add to dashboard Cite

IMPORTANCE Surgical interventions are a key part of the therapeutic arsenal, especially in refractory and stable vitiligo. Comparison of treatment outcomes between the different surgical procedures and their respective adverse effects has not been adequately studied.OBJECTIVE To investigate the reported treatment response following different surgical modalities in patients with vitiligo.DATA SOURCES A comprehensive search of the MEDLINE, Embase, Web of Science, and Cochrane Library databases from the date of database inception to April 18, 2020, was conducted. The key search terms used were vitiligo, surgery, autologous, transplantation, punch, suction blister, and graft.STUDY SELECTION Of 1365 studies initially identified, the full texts of 358 articles were assessed for eligibility. A total of 117 studies were identified in which punch grafting (n = 19), thin skin grafting (n = 10), suction blister grafting (n = 29), noncultured epidermal cell suspension (n = 45), follicular cell suspension (n = 9), and cultured epidermal cell suspension (n = 17) were used.DATA EXTRACTION AND SYNTHESIS Three reviewers independently extracted data on study design, patients, intervention characteristics, and outcomes. Random effects meta-analyses using generic inverse-variance weighting were performed. MAIN OUTCOMES AND MEASURESThe primary outcomes were the rates of greater than 90%, 75%, and 50% repigmentation response. These rates were calculated by dividing the number of participants in an individual study who showed the corresponding repigmentation by the total number of participants who completed the study. The secondary outcomes were the factors associated with treatment response to the surgical intervention. RESULTS Among the 117 unique studies and 8776 unique patients included in the analysis, rate of repigmentation of greater than 90% for surgical interventions was 52.69% (95% CI, 46.87%-58.50%) and 45.76% (95% CI, 30.67%-60.85%) for punch grafting, 72.08% (95% CI, 54.26%-89.89%) for thin skin grafting, 61.68% (95% CI, 47.44%-75.92%) for suction blister grafting, 47.51% (95% CI, 37.00%-58.03%) for noncultured epidermal cell suspension, 36.24% (95% CI, 18.92%-53.57%) for noncultured follicular cell suspension, and 56.82% (95% CI, 48.93%-64.71%) for cultured epidermal cell suspension. The rate of repigmentation of greater than 50% after any surgical intervention was 81.01% (95% CI, 78.18%-83.84%). In meta-regression analyses, the treatment response was associated with patient age (estimated slope, −1.1418), subtype of vitiligo (estimated slope, 0.3047), and anatomical sites (estimated slope, −0.4050). CONCLUSIONS AND RELEVANCEThe findings of this systematic review and meta-analysis suggest that surgical intervention can be an effective option for refractory stable vitiligo. An appropriate procedure should be recommended based on patient age, site and size of the lesion, and costs.

show abstract

Stable Vitiligo Treated by a Combination of Low-Dose Oral Pulse Betamethasone and Autologous, Noncultured Melanocyte-Keratinocyte Cell Transplantation

Abstract: Combined treatment of oral betamethasone and melanocyte cell transplantation has a potential to produce complete repigmentation in patients with large vitiliginous areas.

Cited by 13 publications

References 15 publications

Update on skin repigmentation therapies in vitiligo

Update on skin repigmentation therapies in vitiligo

Treatment of Gray Hair in Vitiligo Patients by Direct Melanocytes Transplant Using Needling Micrografting and Dermabrasion Techniques

Surgical Interventions for Patients With Vitiligo

Contact Info

Product

Resources

About