Stage at Diagnosis and Prognosis of Colorectal, Stomach, Lung, Liver, Kidney, and Bladder Cancers in Dialysis Patients: A Multicenter Retrospective Study Using Cancer Registry Data and Administrative Data

Kida, Naoko; Morishima, Toshitaka; Tsubakihara, Yoshiharu; Miyashiro, Isao

doi:10.1159/000521603

Cited by 3 publications

(4 citation statements)

References 33 publications

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“…These results underscored the importance of record linkage for better risk adjustment because both administrative and registry data contribute unique prognostic information. In fact, numerous cancer-related studies on health services research have similarly used record-linked databases such as the SEER-Medicare Linked Database 5 – 7 , 12 , 14 – 20 , 22 – 24 , 32 .…”

Section: Discussionmentioning

confidence: 99%

“…The study database was produced through the linkage of hospital-based cancer registry data, prefectural cancer registry data, and administrative data. The data were obtained with support from the Council for Coordination of Designated Cancer Care Hospitals in Osaka 15 – 20 .…”

Section: Methodsmentioning

confidence: 99%

“…Cancer registry data and administrative data have been linked to allow for adjustments in case mix among Japanese cancer patients 14 . Previous studies have also shown that such linked data can be used to identify prognostic factors of cancer 15 – 20 .…”

Section: Introductionmentioning

confidence: 99%

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Between-hospital variations in 3-year survival among patients with newly diagnosed gastric, colorectal, and lung cancer

Morishima

Okawa

Koyama

et al. 2022

Sci Rep

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Due to increases in cancer survivability, quality assessments of cancer care must include long-term outcomes. This multicenter retrospective cohort study evaluated between-hospital variations in the 3-year survival rates of patients with gastric, colorectal, and lung cancer irrespective of treatment modality. We linked cancer registry data and administrative data from patients aged 18–99 years who were diagnosed with gastric, colorectal, or lung cancer between 2013 and 2015 in Osaka Prefecture, Japan. The 3-year survival rates were adjusted for potential prognostic factors using multilevel logistic regression models. Between-hospital variations were visually evaluated using funnel plots. We analyzed 10,296 gastric cancer patients from 30 hospitals, 9276 colorectal cancer patients from 30 hospitals, and 7978 lung cancer patients from 28 hospitals. The 3-year survival rate was 70.2%, 75.2%, and 45.0% for gastric, colorectal, and lung cancer, respectively. In the funnel plots, the adjusted survival rates of gastric and colorectal cancer for all hospitals lay between the lower and upper control limits of two standard deviations of the average survival rates. However, the adjusted survival rates of lung cancer for four hospitals lay below the lower limit while that for two hospitals lay above the upper limit. Older age, men, advanced cancer stage, comorbidities, functional disability, emergency admission, current/ex-smokers, and underweight were independently associated with poorer survival. In conclusion, there were between-hospital variations in 3-year survival for lung cancer even after adjusting for case mix. Quality improvement initiatives may be needed to raise the consistency of care.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Between-hospital variations in 3-year survival among patients with newly diagnosed gastric, colorectal, and lung cancer

Morishima

Okawa

Koyama

et al. 2022

Sci Rep

Self Cite

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“…First, clinical data from a hospital-based cancer registry were linked with administrative data produced by hospitals for reimbursements under Japan's Diagnosis Procedure Combination/Per-Diem Payment System. The details of this record-linked database have been reported previously [19][20][21][22][23][24][25][26]. Briefly, the hospital-based cancer registry collects patient demographic information, as well as information on the diagnosis and treatment of newly diagnosed cancer cases; this includes the date of diagnosis, topographical and morphological codes based on the International Classification of Diseases for Oncology Third Edition (ICD-O-3), cancer stage at the time of diagnosis based on the Seventh Edition of the Union for International Cancer Control staging system, and cancer treatment modality.…”

Section: Study Design and Data Sourcementioning

confidence: 99%

Patterns of staging, treatment, and mortality in gastric, colorectal, and lung cancer among older adults with and without preexisting dementia: a Japanese multicentre cohort study

et al. 2023

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Background Little is known about dementia’s impact on patterns of diagnosis, treatment, and outcomes in cancer patients. This study aimed to elucidate the differences in cancer staging, treatment, and mortality in older cancer patients with and without preexisting dementia. Methods Using cancer registry data and administrative data from 30 hospitals in Japan, this multicentre retrospective cohort study examined patients aged 65–99 years who were newly diagnosed with gastric, colorectal, or lung cancer in 2014–2015. Dementia status (none, mild, and moderate-to-severe) at the time of cancer diagnosis was extracted from clinical summaries in administrative data, and set as the exposure of interest. We constructed multivariable logistic regression models to analyse cancer staging and treatment, and multivariable Cox regression models to analyse three-year survival. Results Among gastric (n = 6016), colorectal (n = 7257), and lung (n = 4502) cancer patients, 5.1%, 5.8%, and 6.4% had dementia, respectively. Patients with dementia were more likely to receive unstaged and advanced-stage cancer diagnoses; less likely to undergo tumour resection for stage I, II, and III gastric cancer and for stage I and II lung cancer; less likely to receive pharmacotherapy for stage III and IV lung cancer; more likely to undergo tumour resection for all-stage colorectal cancer; and more likely to die within three years of cancer diagnosis. The effects of moderate-to-severe dementia were greater than those of mild dementia, with the exception of tumour resection for colorectal cancer. Conclusion Older cancer patients with preexisting dementia are less likely to receive standard cancer treatment and more likely to experience poorer outcomes. Clinicians should be aware of these risks, and would benefit from standardised guidelines to aid their decision-making in diagnosing and treating these patients.

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大阪府における透析患者の大腸，胃，肺がんの治療実態

Kida

Morishima

Tsubakihara

2022

Nihon Toseki Igakkai Zasshi

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Keywords： epidemiological method, maintenance dialysis, tumor staging, Diagnosis Procedure Combination, chemotherapy 〈Abstract〉 Cancer is the third most common cause of death among dialysis patients in Japan. Nevertheless, there are no guidelines for the treatment of cancer in dialysis patients. This study aimed to examine the treatment of cancer in dialysis patients and non dialysis patients according to cancer stage in real world settings. In this multicenter retrospective cohort study, cancer registry data and administrative data were used to identify dialysis patients (n＝687) and non dialysis patients (n＝47900) aged 18 79 years who were newly diagnosed with colorectal, stomach, or lung cancer between 2010 and 2015 at 36 hospitals in Osaka Prefecture, Japan. The records of these datasets were linked to obtain patient level information about dialysis treatment, cancer diagnoses, and cancer specific treatments. Dialysis patients were significantly more likely to undergo endoscopic resection and less likely to undergo surgical resection for early stage colorectal and stomach cancer than non dialysis patients. Dialysis patients were significantly more likely to receive radiotherapy for early stage lung cancer. Dialysis patients were significantly less likely to undergo combination treatment involving surgical resection and chemotherapy for colorectal, stomach, or lung cancer of any stage. Dialysis patients were significantly less likely to receive chemotherapy alone for distant recurrent stomach or lung cancer. Dialysis patients were significantly

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Stage at Diagnosis and Prognosis of Colorectal, Stomach, Lung, Liver, Kidney, and Bladder Cancers in Dialysis Patients: A Multicenter Retrospective Study Using Cancer Registry Data and Administrative Data

Cited by 3 publications

References 33 publications

Between-hospital variations in 3-year survival among patients with newly diagnosed gastric, colorectal, and lung cancer

Between-hospital variations in 3-year survival among patients with newly diagnosed gastric, colorectal, and lung cancer

Patterns of staging, treatment, and mortality in gastric, colorectal, and lung cancer among older adults with and without preexisting dementia: a Japanese multicentre cohort study

大阪府における透析患者の大腸，胃，肺がんの治療実態

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