2020
DOI: 10.1186/s12910-020-0454-y
|View full text |Cite
|
Sign up to set email alerts
|

Stakeholder views on the acceptability of human infection studies in Malawi

Abstract: Background: Human infection studies (HIS) are valuable in vaccine development. Deliberate infection, however, creates challenging questions, particularly in low and middle-income countries (LMICs) where HIS are new and ethical challenges may be heightened. Consultation with stakeholders is needed to support contextually appropriate and acceptable study design. We examined stakeholder perceptions about the acceptability and ethics of HIS in Malawi, to inform decisions about planned pneumococcal challenge resear… Show more

Help me understand this report
View preprint versions

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

1
14
0

Year Published

2021
2021
2024
2024

Publication Types

Select...
6
3
1

Relationship

2
8

Authors

Journals

citations
Cited by 28 publications
(15 citation statements)
references
References 28 publications
1
14
0
Order By: Relevance
“…With increasing descriptions of new CHIM studies being mooted, so too the need for robust frameworks to ensure appropriate engagement is strengthened. This is especially true of CHIMs for development in LMICs 94 . The bioethical discussion surrounding such studies has included the utility and practicality of public involvement and engagement within a rapidly changing landscape 27,95 .…”
Section: Discussionmentioning
confidence: 99%
“…With increasing descriptions of new CHIM studies being mooted, so too the need for robust frameworks to ensure appropriate engagement is strengthened. This is especially true of CHIMs for development in LMICs 94 . The bioethical discussion surrounding such studies has included the utility and practicality of public involvement and engagement within a rapidly changing landscape 27,95 .…”
Section: Discussionmentioning
confidence: 99%
“…In these settings, prior exposure may be associated with less severe symptoms and the illness seen as an 'everyday occurrence' (5,6). Since HIS can help to address global burdens of vaccine-preventable diseases, their conduct in countries that carry the highest burden of these conditions is potentially important (3,7,8).…”
Section: Human Infection Studiesmentioning
confidence: 99%
“…The hierarchy of engagement was likely to diminish their contributions as less accurate or useful than other forms of evidence used in the decision-making process (9,25). Two way communication between the government and stakeholders throughout the policy development process is essential for building trust and social accountability (26,27). This should include feedback mechanisms at the implementation stage so stakeholders, especially CSOs and facilities can identify where the policy is not meeting the population needs (2).…”
Section: Inclusive Engagementmentioning
confidence: 99%