STAMBPL1 knockdown has antitumour effects on gastric cancer biological activities

Yu, Dajun; Qian, Jun; Jin, Xin; Li, Jing; Guo, Chenxu; Yue, Xicheng

doi:10.3892/ol.2019.10789

Cited by 11 publications

(10 citation statements)

References 26 publications

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“…The MMRN2 gene located on 10q22 interacts with the VEGF pathway to promote angiogenesis and hence tumor growth ( Lorenzon et al, 2012 ). The ANKRD22 is reported to promote non-small cell lung cancer ( Yin et al, 2017 ), and STAMBPL1 is oncogenic in gastric cancer ( Yu et al, 2019 ). Loss of epigenetic control of SNCG gene is a marker of metastasis in several cancers ( Jin et al, 2012 ).…”

Section: Discussionmentioning

confidence: 99%

Recurring Translocations in Barrett’s Esophageal Adenocarcinoma

et al. 2021

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Barrett’s esophagus (BE) is a premalignant metaplasia in patients with chronic gastroesophageal reflux disease (GERD). BE can progress to esophageal adenocarcinoma (EA) with less than 15% 5-year survival. Chromosomal aneuploidy, deletions, and duplication are early events in BE progression to EA, but reliable diagnostic assays to detect chromosomal markers in premalignant stages of EA arising from BE are lacking. Previously, we investigated chromosomal changes in an in vitro model of acid and bile exposure-induced Barrett’s epithelial carcinogenesis (BEC). In addition to detecting changes already known to occur in BE and EA, we also reported a novel recurring chromosomal translocation t(10:16) in the BE cells at an earlier time point before they undergo malignant transformation. In this study, we refine the chromosomal event with the help of fluorescence microscopy techniques as a three-way translocation between chromosomes 2, 10, and 16, t(2:10;16) (p22;q22;q22). We also designed an exclusive fluorescent in situ hybridization for esophageal adenocarcinoma (FISH-EA) assay that detects these chromosomal breakpoints and fusions. We validate the feasibility of the FISH-EA assay to objectively detect these chromosome events in primary tissues by confirming the presence of one of the fusions in paraffin-embedded formalin-fixed human EA tumors. Clinical validation in a larger cohort of BE progressors and non-progressors will confirm the specificity and sensitivity of the FISH-EA assay in identifying malignant potential in the early stages of EA.

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Section: Discussionmentioning

confidence: 99%

Recurring Translocations in Barrett’s Esophageal Adenocarcinoma

et al. 2021

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“…The following sections describe the mechanisms through which each DUB modulates several types of RCD and their physiological functions through various molecular mechanisms in detail. [189,190] ↓Intrinsic apoptosis ↓NF-κB ↑Gastric cancer [191] *: Upstream regulators of DUB.…”

Section: Dubs Regulating Diverse Rcdmentioning

confidence: 99%

“…STAMBPL1, a member of the AMSH DUB family, is reportedly involved in cancer [ 191 ]. Studies on the role of STAMBPL1 in RCD are limited to intrinsic and extrinsic apoptosis.…”

Section: Dubs Regulating Diverse Rcdmentioning

confidence: 99%

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Deubiquitinases: Modulators of Different Types of Regulated Cell Death

Lee

Kim

Hwang

et al. 2021

IJMS

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The mechanisms and physiological implications of regulated cell death (RCD) have been extensively studied. Among the regulatory mechanisms of RCD, ubiquitination and deubiquitination enable post-translational regulation of signaling by modulating substrate degradation and signal transduction. Deubiquitinases (DUBs) are involved in diverse molecular pathways of RCD. Some DUBs modulate multiple modalities of RCD by regulating various substrates and are powerful regulators of cell fate. However, the therapeutic targeting of DUB is limited, as the physiological consequences of modulating DUBs cannot be predicted. In this review, the mechanisms of DUBs that regulate multiple types of RCD are summarized. This comprehensive summary aims to improve our understanding of the complex DUB/RCD regulatory axis comprising various molecular mechanisms for diverse physiological processes. Additionally, this review will enable the understanding of the advantages of therapeutic targeting of DUBs and developing strategies to overcome the side effects associated with the therapeutic applications of DUB modulators.

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“…For example, there is a recurrent event K405Rfs*21 event in STAM-binding protein-like 1 ( STAMBPL1 ). This gene is not well understood, though it appears to be positively associated with prostate and gastric cancers 15, 16 , and mutations in this region have been implicated in canine polyp development 17 .…”

mentioning

confidence: 99%

Selection for or against Escape from Nonsense Mediated Decay is a Novel Signature for the Detection of Cancer Genes

Kumar¹,

Burns²,

Vandeventer³

et al. 2021

Preprint

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Escape from nonsense mediated decay (NMD-) can produce activated or inactivated gene products, and bias in rates of escape can identify functionally important genes in germline disease. We hypothesized that the same would be true of cancer genes, and tested for NMD- bias within The Cancer Genome Atlas pan-cancer somatic mutation dataset. We identify 29 genes that show significantly elevated or suppressed rates of NMD-. This novel approach to cancer gene discovery reveals genes not previously cataloged as potentially tumorigenic, and identifies many potential driver mutations in known cancer genes for functional characterization.

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STAMBPL1 knockdown has antitumour effects on gastric cancer biological activities

Cited by 11 publications

References 26 publications

Recurring Translocations in Barrett’s Esophageal Adenocarcinoma

Recurring Translocations in Barrett’s Esophageal Adenocarcinoma

Deubiquitinases: Modulators of Different Types of Regulated Cell Death

Selection for or against Escape from Nonsense Mediated Decay is a Novel Signature for the Detection of Cancer Genes

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