Standardisation and Quality Control Parameters of <i>Phalatrikadi Ghana Vati</i> – An <i>Ayurvedic</i> Formulation

Abstract

Drug standardisation, profiling, and quality control continue to be a challenge for Ayurvedic medicines due to their wide range of dosage forms. Different dosage forms like decoctions and powders result in non-compliance from the patient owing to their palatability or cumbersome methods of administration. The present study aims to pharmaceutically process a traditional decoction, Phalatrikadi Kwatha, and standardise it into tablet form, known as Phalatrikadi Ghana Vati (PGV). PGV was prepared and subjected to organoleptic, physicochemical, phytochemical analysis, and HPTLC analysis in an attempt to define its quality parameters and standardisation. Distinct fingerprints of Phalatrikadi Ghana Vati were obtained. Out of the eight components identified, the components with Rf values 0.08, 0.74, 0.65 and 0.83 were more predominant with more percent areas 9.65%, 14.91%, 18.02%, and 40.67%, respectively Quantitative physicochemical analysis revealed loss on drying as 1.33%, ash value as 4.53%, water-soluble extractive as 15.38%, alcohol extractive as 9.63% and pH as 5.1. The study also revealed the presence of alkaloids, glycosides, flavonoids, amino acids, and saponins. Preliminary profiling of PGV exhibited striking analytical characteristics. The physicochemical parameters were in the range of a standard tablet. The quantitative physicochemical parameters and HPTLC profile can be used as a reference standard for the quality control of Phalatrikadi Ghan Vati.