Standardization and Stability Evaluation of Dry Extracts of Myracrodruon Urundeuva Allemão Obtained by Spray Drier

Abstract

Objective: This study aimed to obtain standardised dry extracts of Miracrodruon urundeuva Allemão using spray-dryer and evaluate the stability of the extracts. Methods:It evaluated the drying parameters: Proportion of colloidal silicon dioxide (CSD) (10, 15 and 20%), inlet temperature (160, 170 and 180 °C) and feed rate (4, 6 and 8 ml/min). The study of the accelerated stability of dry extract occurred in temperature of 40 °C (±2 °C) and relative humidity of 75% (±5%) for 6 mo. The anti-inflammatory activity of the dry extract was evaluated in Swiss mice by the paw edema method. Results:Variations in drying conditions did not represent significant variations in yields of the process. The drying temperature and feed rate significantly influenced the concentration of quercetin (p≤0.05). The increase in inlet temperature and feed flow promoted the increase of quercetin concentration in the extracts. The stability study showed that the concentration of quercetin in dry extract was stable over a period of 6 mo. The dry extract showed anti-inflammatory activity in mice orally. Conclusion:A condition of 10% of colloidal silicon dioxide with an 180 °C inlet temperature and a feed rate of 8 ml/min was considered the most adequate for obtaining the extracts and the drying process resulted in stable dry extracts and the quercetin was a suitable biomarker for monitoring the process.

Antifungal Activity of a Hydroethanolic Extract From Astronium urundeuva Leaves Against Candida albicans and Candida glabrata

“…extracts, including chalcones, flavonoids precursors, essential oils, hydrolizable and condensed tannins that are considered to be the main responsible for the therapeutic activities. The presence of volatile oils justifies the typical aroma found in A. urundeuva leaves (Costa et al, 2014; Machado et al, 2016; Leite et al, 2017). We have previously reported on the in vitro antifungal activity of different extracts from a number of Astronium sp., with the hydroethanolic plant extract prepared from leaves of A. urundeuva displaying the most potent activity against Candida albicans (Bonifácio et al, 2015).…”

“…This is an arboreal species widely distributed in South America, especially in the arid environment of Cerrado, pollinated by wind and containing a small flower. The size of this specie varies according to region of occurrence, but usually features 30 m high, with inflorescence between July and September and ripening of the fruit from September to October, consisting of a single seed (Machado and Oliveira, 2014; Leite et al, 2017). It is considered one of the most popular traditional medicinal plants in Northeastern Brazil as treatment to various diseases, including gastritis, gastric ulcers, cervicitis, vaginitis, hemorrhoids and as anti-inflammatory and natural healing (Calou et al, 2014; Machado and Oliveira, 2014; Resende et al, 2015).…”

Thermal Degradation Kinetics of Kaempferol and Quercetin in the Pre-Formulated of the Standardized Extracts of Poincianella Pyramidalis (Tul.) L. P. Queiroz Obtained by Spray Dryer

“…Samples were prepared according to the previously described methodology [27]. A standard solution 4μg/ml of de kampferol and quercetin was prepared with methanol: water (70:30).…”

CARACTERIZAÇÃO ANATÔMICA E HISTOQUÍMICA DA LÂMINA FOLIAR DE Calotropis procera (Aiton) W.T.Aiton

“…A Organização Mundial da Saúde (OMS) reconhece a importância da fitoterapia, sugerindo ser uma alternativa viável e importante também às populações dos países em desenvolvimento, já que seu custo é diminuído (FERREIRA et al, 2014;GUO et al, 2016;LEITE et al, 2017). Garantir à população brasileira o acesso seguro e o uso racional de plantas medicinais e fitoterápicos, promovendo o uso sustentável da biodiversidade, o desenvolvimento da cadeia produtiva e da indústria nacional.…”