Standardized IOS Reference Values Define Peripheral Airway Impairment-Associated Uncontrolled Asthma Risk Across Ethnicity in Children

Galant, Stanley P.; Fregeau, William; Pabelonio, Neil; Morphew, Tricia; Tirakitsoontorn, Pornchai

doi:10.1016/j.jaip.2020.03.040

Cited by 26 publications

(28 citation statements)

References 31 publications

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“…6 Moreover, impulse oscillometric variables linked to small airway function (such as the frequency dependence of resistance or reactance area) have been found to be associated with a loss of asthma control and the severity of asthma. [35][36][37] However, there are few studies characterizing ICS treatment responses that use impulse oscillometry.…”

Section: Discussionmentioning

confidence: 99%

Impulse oscillometry and free-running tests for diagnosing asthma and monitoring lung function in young children

Burman

Malmberg

Remes

et al. 2021

Annals of Allergy, Asthma & Immunology

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Background: Separating individuals with viral-induced wheezing from those with asthma is challenging, and there are no guidelines for children under 6 years of age. Impulse oscillometry, however, is feasible in 4-year-old children.Objective: To explore the use of impulse oscillometry in diagnosing and monitoring asthma in young children and evaluating treatment response to inhaled corticosteroid (ICS). Methods: A total of 42 children (median age 5.3 years, range 4.0-7.9 years) with physician-diagnosed asthma and lability in oscillometry were followed for 6 months after initiation of ICS treatment. All children performed the 6-minute free-running test and impulse oscillometry at 3 time points. After the baseline, they attended a second visit when they had achieved good asthma control and a third visit approximately 60 days after the second visit. A positive ICS response was defined as having greater than 19 points in asthma control test and no hyperreactivity on the third visit. Results: In total, 38 of 42 children responded to ICS treatment. Exercise-induced increases of resistance at 5 Hz decreased after ICS treatment (61% vs 18% vs 13.5%, P < .001), and running distance during the 6-minute test was lengthened (800 m vs 850 m vs 850 m, P = .001). Significant improvements in childhood asthma control scores occurred between the baseline and subsequent visits (21 vs 24 vs 24, P < .001) and acute physicians' visits for respiratory symptoms (1, (0−6) vs 0, (0−2), P = .001). Similar profiles were observed in children without aeroallergen sensitization and among those under 5 years of age. Conclusion: Impulse oscillometry is a useful tool in diagnosing asthma and monitoring lung function in young children.

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Section: Discussionmentioning

confidence: 99%

Impulse oscillometry and free-running tests for diagnosing asthma and monitoring lung function in young children

Burman

Malmberg

Remes

et al. 2021

Annals of Allergy, Asthma & Immunology

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“…Tirakitsoontorn et al also reported X5 may be well suited to identify peripheral airway impairment phenotype in the clinical setting [18] . Galant et al further confirmed that X5 decreased significantly in the uncontrolled asthma group [26] . Fres also known as resonant frequency refers to the frequency when the elastic recoil of the airways and lungs is equal and opposite to the inertance of the system, that is, the reactance is zero.…”

Section: Discussionmentioning

confidence: 84%

The predictive value of impulse oscillometry for asthma exacerbations in childhood: a systematic review and meta-analyses

Ling

Niu

et al. 2020

Preprint

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Background: Several studies have explored the predictive value of impulse oscillometry (IOS) for asthma exacerbations in childhood, but its specific parameters are still unclear. Therefore, we designed this meta-analysis to determine the related indicators of acute asthma attacks. Methods: A comprehensive literature search was performed in July 2020 based on Pubmed, Embase, and Web of science database. Weighted mean differences (WMD) were calculated using Fixed-or random-effects models. Results: A total of 615 patients from 6 trials were included in this analysis. IOS may be a useful tool to predict asthma exacerbations. And the results showed that R5 (WMD =-1.21, 95%CI:-1.55 to-0.87, P<0.001), Fres (WMD =-1.34, 95%CI:-2.03 to-0.65,P=0.018) and AX (WMD =-7.35, 95%CI:-9.94 to-4.76,P<0.001) had significant correlation with asthma exacerbations. In addition, X5 may also predict the acute attack of asthma (WMD =0.81, 95%CI: 0.56 to 1.01, P<0.001). Conclusion: R5, AX, Fres, and X5 may be able to identify the risk of an acute attack of asthma. Besides, our research further demonstrated that peripheral airway injury may play an important role in the acute attack of asthma.

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“…Tirakitsoontorn et al 18 also reported X5 may be well suited to identify peripheral airway impairment phenotype in the clinical setting. Galant et al 30 further confirmed that X5 decreased significantly in the uncontrolled asthma group. When the respective magnitudes of inertance and elastance are equal, the elastic contribution exactly equals the inertial contribution.…”

Section: Discussionmentioning

confidence: 85%

The predictive value of impulse oscillometry for asthma exacerbations in childhood: A systematic review and meta‐analyses

Ling

Niu

et al. 2021

Pediatric Pulmonology

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Objective: Several studies have explored the predictive value of impulse oscillometry (IOS) for asthma exacerbations in childhood, but its specific parameters are still unclear. Therefore, we designed this meta-analysis to determine the related indicators of acute asthma attacks.Methods: A comprehensive literature search was performed on July 9, 2020 based on PubMed, Embase, and Web of Science database. Weighted mean differences (WMDs) were calculated using fixed-or random-effects models.Results: A total of 615 patients from six trials were included in this analysis. IOS may be a useful tool to predict asthma exacerbations. And the results showed that R5 (WMD = −1.21, 95% CI: −1.55 to −0.87, p < .001), Fres (WMD = −1.34, 95% CI: −2.03 to −0.65, p = .018), and AX (WMD = −7.35, 95% CI: −9.94 to −4.76, p < .001) had significant correlation with asthma exacerbations. In addition, X5 may also predict the acute attack of asthma (WMD = 0.81, 95% CI: 0.56 to 1.01, p < .001).Conclusions: R5, AX, Fres, and X5 may be able to identify the risk of an acute attack of asthma. Besides, our research further demonstrated that peripheral airway injury may play an important role in the acute attack of asthma.

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Standardized IOS Reference Values Define Peripheral Airway Impairment-Associated Uncontrolled Asthma Risk Across Ethnicity in Children

Cited by 26 publications

References 31 publications

Impulse oscillometry and free-running tests for diagnosing asthma and monitoring lung function in young children

Impulse oscillometry and free-running tests for diagnosing asthma and monitoring lung function in young children

The predictive value of impulse oscillometry for asthma exacerbations in childhood: a systematic review and meta-analyses

The predictive value of impulse oscillometry for asthma exacerbations in childhood: A systematic review and meta‐analyses

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