Standardized Uptake Values of Normal Organs on ¹⁸F-Fluorodeoxyglucose Positron Emission Tomography and Computed Tomography Imaging

Abstract

Standardized uptake values (SUVs) of normal organs were evaluated by 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography and computed tomography (PET-CT) scanning. Seventy patients (38 men and 32 women) with no non-physiological 18F-FDG uptake participated in the study. All patients fasted for at least 4 h before PET-CT imaging and their fasting blood glucose levels were within the normal range. Image acquisition was performed after intravenous administration of 18F-FDG and images were obtained from the vertex to the upper thigh region. The SUVs of various organs were determined from the transverse views. The uptake of 18F-FDG was highest in the cerebrum, cerebellum, myocardium, tonsils, liver and spleen in both sexes. Having knowledge of the physiological uptake of 18F-FDG and normal organ SUVs is required for the correct interpretation of whole-body 18F-FDG-PET-CT studies.

Gastrointestinal 18F-FDG accumulation on PET without a corresponding CT abnormality is not an early indicator of cancer development

“…Our SUVmax measurements correspond well with the data published by Wang et al and Zincirkeser et al [26,27], even if the range of SUVmax detected in our study exceeds their measurements. This finding, supposedly, may be a result of our substantially higher number of patients investigated.…”

Semiquantitative Analysis of the Biodistribution of the Combined18F-NaF and18F-FDG Administration for PET/CT Imaging

“…Our 18 F-FDG biodistribution analysis was consistent with previous results (11)(12)(13)(14), and our 18 F-NaF uptake data are similar to those from previous reports analyzing the 18 F-NaF uptake in normal bone (15,16).…”

18 F-FDG PET/CT for initial staging in breast cancer patients – Is there a relevant impact on treatment planning compared to conventional staging modalities?

“…Afterwards, SUV max values were measured in a region of interest. Although a general cut off value of SUV max was not set, lesions were considered as malignant if the SUV max definitely exceeded the physiological uptake of an anatomic structure or organ [10,11]. Final interpretation was based on both the functional and morphological/anatomical information.…”