Standardizing definitions and reporting guidelines for the infertility core outcome set: an international consensus development study

Abstract

a face-to-face consensus development meeting, which agreed consensus definitions. A standardized approach to reporting was also developed as part of the process. Participants/Materials, Setting, Methods: Healthcare professionals, researchers, and people with fertility problems were brought together in an open and transparent process using formal consensus development methods. Main Results and the Role of Chance: Forty-four potential definitions were inventoried across four definition development initiatives, including the Harbin Consensus Conference Workshop Group and International Committee for Monitoring Assisted Reproductive Technologies, 12 clinical practice guidelines, and Cochrane Gynaecology and Fertility Group guidelines. Twenty-seven participants, from 11 countries, contributed to the consensus development meeting. Consensus definitions were successfully developed for all core outcomes. Specific recommendations were made to improve reporting. Limitations, Reasons for Caution: We used consensus development methods, which have inherent limitations. There was limited representation from low-and middle-income countries. Wider Implications of the Findings: A minimum data set should assist researchers in populating protocols, case report forms, and other data collection tools. The generic reporting table should provide clear guidance to researchers and improve the reporting of their results within journal publications and conference presentations.

Outcome reporting across randomized controlled trials evaluating potential treatments for male infertility: a systematic review

“…To address inconsistencies in outcome reporting across male and female infertility trials, an international working group of healthcare professionals and researchers have developed the Core Outcome Measures for Infertility Trials (COMMIT) initiative ( Core Outcomes in Women's and Newborn Health Initiative, 2014 ). This initiative will develop stakeholder-driven development of core outcome sets relevant to clinicians, researchers, and patients and has developed a consensus strategy for reporting core outcomes and standardizing their definitions ( Duffy et al , 2020 , 2021 ).…”

Recombinant LH supplementation improves cumulative live birth rates in the GnRH antagonist protocol: a multicenter retrospective study using a propensity score-matching analysis

“…Traditionally, live birth rate per embryo transfer has been reported as the success rates of IVF/ICSI [ 37 ]. However, embryo freezing and thawing becomes increasingly universal that live birth rate of a single embryo transfer cycle is not adequate to evaluate the effect of the IVF/ICSI treatment.…”

The Effects of Preimplantation Genetic Testing for Aneuploidy (PGT-A) on Patient-Important Outcomes in Embryo Transfer Cases: A Meta-Analysis

“…The definition of the outcomes given by the authors of each study was extracted to evaluate the possible heterogeneity derived from different classifications. For the studies not stating definitions, outcomes were identified according to the guide for the standardization of definitions and reports in infertility ( 24 ). All reviewers extracted the data independently and in duplicate and disagreements were solved by consensus or intervention of a third reviewer.…”