Standardizing percutaneous Microwave Ablation in the treatment of Lung Tumors: a prospective multicenter trial (MALT study)

Iezzi, Roberto; Cioni, Roberto; Basile, Domenico; Tosoratti, N.; Posa, Alessandro; Busso, Marco; Cappelli, Carla; Margaritora, Stefano; Ambrogi, Marcello Carlo; Cassano, Alessandra; Scandiffio, Rossella; Calandri, Marco; Crocetti, Laura; Valentini, Vincenzo; Manfredi, Riccardo; Veltri, Andrea

doi:10.1007/s00330-020-07299-2

Cited by 25 publications

(16 citation statements)

References 34 publications

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“…Moreover, with the increasing exploration of disease indications for thermal ablation, MWA has gradually emerged as an alternative to surgical resection for solid small malignant tumors originated from liver, renal, and lung. [27][28][29][30] Although MWA was a relatively novel technique, a significant decrease in operating time, recovery unit, hospital stay, and sufficient therapeutic effects were determined in recent study works. 23,31 Regarding benign thyroid nodules including thyroid 32 and parathyroid adenoma, 33 MWA has shown an excellent therapeutic effect.…”

Section: Microwave Ablation (Mwa)mentioning

confidence: 99%

Thermal Ablation for Papillary Thyroid Microcarcinoma: How Far We Have Come?

Min

Wang

Chen

et al. 2020

CMAR

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Purpose Thermal ablation (TA), as one of the most currently remarkable technologies, has achieved great success in many malignant diseases including but not limited to hepatic and renal carcinoma. In recent years, this technology was gradually introduced to the treatment of papillary thyroid microcarcinoma (PTMC) and even papillary thyroid carcinoma (PTC). Thereby, we summarized the current progress of TA development in the treatment of PTMC. Methods The latest relevant literature from the PubMed database with keywords “thermal ablation”, “papillary thyroid microcarcinoma”, “microwave ablation”, “radio-frequency ablation”, and “laser ablation”, among others, were comprehensively reviewed in this article. The follow-up outcomes of patients in these articles were analyzed. Results The efficacy and safety of TA including microwave ablation (MWA), laser ablation (LA), and radiofrequency ablation (RFA) in the treatment of PTC and PTC have been intensively studied. Based on existing clinical trials, the relatively long-term follow-up (range, from 6 to 64.2 months) results in MWA, LA, and RFA were satisfactory that tumor volume reduction rate (VRR) reached and even surpass 99%. Compared with routine surgery methods (total thyroidectomy and lobectomy), the incidence rate of complications was relatively lower and the recurrence rate of TA techniques was not statistically significant, whereas the operative time, blood loss, length of hospital stay, and hospital cost were significantly decreased. Conclusion TA presents the same satisfactory therapeutic effects but minimal postoperative trauma can significantly improve the patients’ quality of life. However, future larger sample, multicenter, and prospective randomized controlled trials are urgently needed to validate the feasibility of TA in dealing with PTMC.

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Section: Microwave Ablation (Mwa)mentioning

confidence: 99%

Thermal Ablation for Papillary Thyroid Microcarcinoma: How Far We Have Come?

Min

Wang

Chen

et al. 2020

CMAR

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“…It should be noted that results from clinical trials were not included in this review. If one is looking for information about the clinical performance and trials related to MWA, several detailed reports, for example [49][50][51][52][53][54][55][56][57], are available.…”

Section: Introductionmentioning

confidence: 99%

A review of antenna designs for percutaneous microwave ablation

et al. 2021

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Microwave (MW) antenna is a key element in microwave ablation (MWA) treatments as the means that energy is delivered in a focused manner to the tumor and its surrounding area. The energy delivered results in a rise in temperature to a lethal level, resulting in cell death in the ablation zone. The delivery of energy and hence the success of MWA is closely dependent on the structure of the antennas. Therefore, three design criteria, such as expected ablation zone pattern, efficiency of energy delivery, and minimization of the diameter of the antennas have been the focus along the evolution of the MW antenna. To further improve the performance of MWA in the treatment of various tumors through inventing novel antennas, this article reviews the state-of-the-art and summarizes the development of MW antenna designs regarding the three design criteria.

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“…The overall prognosis of NSCLC remains dismal, with the 5-year survival rate of 16% as reported [4]. In recent decades, thermal ablation has been reported as a primary therapeutic strategy or/and an adjuvant to other treatments for NSCLC, or for the earlystage patients with limited pulmonary reserve who cannot tolerate the surgery [5][6][7], with a high technical success rate up to 96% according to a meta-analysis [8]. Of these, radiofrequency ablation (RFA) and microwave ablation (MWA) are the two most common types, while the latter has the advantages of a higher intra-tumoral temperatures, a larger ablation scope, decreased ablation duration, and deeper penetration [9].…”

Section: Introductionmentioning

confidence: 99%

Survival prediction for non-small cell lung cancer patients treated with CT-guided microwave ablation: development of a prognostic nomogram

et al. 2021

International Journal of Hyperthermia

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Objectives: To explore the outcomes of CT-guided percutaneous microwave ablation (MWA) in nonsmall cell lung cancer (NSCLC) patients, and then develop an effective nomogram to predict the survival. Methods: NSCLC patients treated with MWA were randomly allocated to either the training cohort or the validation cohort (3:1). The primary outcome measurement was overall survival (OS), whose predictors were identified by univariate and multivariate analyses in the training cohort. Then, a predictive nomogram was developed to predict the OS, with the predictive accuracy evaluated by C-statistic and receiver operating characteristic in both the training and validation cohorts. Results: A total of 234 patients (training cohort: n ¼ 176; validation cohort: n ¼ 58) and 271 tumors with a median OS of 17.0 ± 12.2 months were included. The predictors selected into the nomogram included tumor diameter (hazard ratio [HR], 2.12; 95% confidence interval [CI], 1.37-3.30; p < 0.001), extrapulmonary metastases (HR, 1.77; 95% CI, 1.06-2.95; p ¼ 0.030), tumor stage (HR, 1.38; 95% CI, 1.07-1.79; p ¼ 0.013), tumor type (HR, 2.00; 95% CI, 1.48-2.72; p < 0.001) and post-MWA TKIs (HR, 0.55; 95% CI, 0.34-0.89; p < 0.001), based on the results of univariate and multivariate analyses. The C-statistic showed good predictive performance, with a C-statistic of 0.838 (95% CI, 0.779-0.897) internally and 0.808 (95% CI, 0.695-0.920) externally (training cohort and validation cohort, respectively). Conclusions: The nomogram was effective in predicting the OS in NSCLC patients treated with MWA, and could be applied to identify patients who may benefit most from MWA and be helpful for clinical decision making.

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Standardizing percutaneous Microwave Ablation in the treatment of Lung Tumors: a prospective multicenter trial (MALT study)

Cited by 25 publications

References 34 publications

Thermal Ablation for Papillary Thyroid Microcarcinoma: How Far We Have Come?

Thermal Ablation for Papillary Thyroid Microcarcinoma: How Far We Have Come?

A review of antenna designs for percutaneous microwave ablation

Survival prediction for non-small cell lung cancer patients treated with CT-guided microwave ablation: development of a prognostic nomogram

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